Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China

Li, Kuibao; Yao, Chonghua; Yang, Xinchun; Di, Xuan; Li, Na; Dong, Lei; Xu, Li; Zheng, Meimei

doi:10.2188/jea.je20150323

Cited by 20 publications

(17 citation statements)

References 23 publications

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“…Studies assessing the association between BMI and CVD-specific mortality in Chinese hypertensive patients have been limited, and the results have been inconsistent. A prospective cohort study conducted in Beijing involving 2,535 hypertensive patients aged 40–91 found a U-shaped relationship between BMI and CVD death [ 7 ]. However, the sample size of this study was insufficiently powered, and there may be unaccounted confounding factors such as physical activity and dietary factors that bias the results of the study.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, hypertension is a major cause of premature deaths in China [ 4 – 6 ]. Several cohort studies have found a U-shaped relationship between BMI and all-cause mortality in hypertensive patients, which means that both relatively low and high BMI will increase mortality [ 7 , 8 ]. Overweight and obesity are associated with various cardiovascular disease risk factors and increased cardiovascular events [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China

Zhu

et al. 2021

Aging

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The aim of our study was to examine the association between body mass index (BMI) and the risk of cardiovascular disease (CVD)-specific mortality among Chinese adults with hypertension by sex. This study included 212,394 adult hypertensive patients aged 20–85 years registered in the records of Minhang District during 2007–2018. Cox proportional hazards regression was performed to evaluate the association between BMI and CVD-specific mortality among Chinese adults with hypertension. There were 14,029 deaths over an average of 8.24 years (range, 0.19–11.96 years). The multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) across BMI categories (< 18.5 kg/m 2 , 18.5–24.9 kg/m 2 [reference group], 25.0–29.9 kg/m 2 , and ≥ 30 kg/m 2 ) for CVD-specific mortality were 1.37 (1.22–1.53), 1.00 (reference), 0.95 (0.90–1.01), and 1.21 (1.04–1.40) in males, and 1.44 (1.31–1.59), 1.00 (reference), 0.96 (0.91–1.01), and 1.04 (0.92–1.17) in females. A U-shaped relationship was observed between BMI and CVD-specific mortality (overall association P < 0.001; non-linearity P < 0.001). This association was attenuated in old age. This study revealed a U-shaped relationship between BMI and CVD-specific mortality among hypertensive men and women. In older people, overweight and obesity are potential factors that reduce the risk of CVD death.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China

Zhu

et al. 2021

Aging

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“…In other studies, the category underweight was not used, only normal BMI<25, and no lower limit for underweight. 36,39 A U-shaped association with BMI is known from other contexts regarding cardiovascular diseases, 40,41 but has not been shown together with arterial stiffness before. Therefore, we suggest that this finding needs to be further investigated and that the underweight individuals should be reported as a separate group in future studies.…”

Section: Arterial Stiffness and Body Compositionmentioning

confidence: 99%

Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study

Fernberg

Fernström

Hurtig-Wennlöf

2017

Eur J Prev Cardiolog

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Background Early changes in the large muscular arteries are already associated with risk factors as hypertension and obesity in adolescence and young adulthood. The present study examines the association between arterial stiffness measurements, pulse wave velocity and augmentation index and lifestyle-related factors, body composition and cardiorespiratory fitness, in young, healthy, Swedish adults. Design This study used a population-based cross-sectional sample. Methods The 834 participants in the study were self-reported healthy, non-smoking, age 18-25 years. Augmentation index and pulse wave velocity were measured with applanation tonometry. Cardiorespiratory fitness was measured by ergometer bike test to estimate maximal oxygen uptake. Body mass index (kg/m) was calculated and categorised according to classification by the World Health Organisation. Results Young Swedish adults with obesity and low cardiorespiratory fitness have significantly higher pulse wave velocity and augmentation index than non-obese young adults with medium or high cardiorespiratory fitness. The observed U-shaped association between pulse wave velocity and body mass index categories in women indicates that it might be more beneficial to be normal weight than underweight when assessing the arterial stiffness with pulse wave velocity. The highest mean pulse wave velocity was found in overweight/obese individuals with low cardiorespiratory fitness. The lowest mean pulse wave velocity was found in normal weight individuals with high cardiorespiratory fitness. Cardiorespiratory fitness had a stronger effect than body mass index on arterial stiffness in multiple regression analyses. Conclusions The inverse association between cardiorespiratory fitness and arterial stiffness is observed already in young adults. The study result highlights the importance of high cardiorespiratory fitness, but also that underweight individuals may be a possible risk group that needs to be further studied.

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“…Pregnant women with hypertension had the average age of 32.02 years old with the body mass index of 29.97, whereas pregnant women with normal blood pressure had the average age of 28.87 years old with the body mass index of 26.22. Overweight or obesity is a risk factor for the occurrence of preeclampsia (Sohlberg et al, 2009;Knight, Kurinczuk, & Spark, 2010;Kazemian et al, 2014) and reveals an ascending pattern with the increase of BMI (Reyes et al, 2012;Bilano et al, 2014;Gudnadóttir et al, 2016;Li et al, 2016). In terms of maternal age, mothers within the range of 30-34 years old are 2 times more likely experience preeclampsia (Choudhury et al, 2014;Chan et al, 2015).…”

Section: Discuccionmentioning

confidence: 99%

Type of Delivery and Length of Stay in Hypertension Patients

Syahriana¹,

Mappaware²,

Hasibuan³

et al. 2018

GJHS

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Introduction: The length of stay (LOS) for pregnant mothers with vaginal delivery is different from that of caesarean delivery. Hypertension during pregnancy may be an indication to conduct caesarean delivery that affects length of stay in hospitals. Material and Methods:The total collected samples were 108 pregnant mothers and they were divided into 2 groups, 54 pregnant mothers with normal blood pressure and 54 pregnant mothers with hypertension. Maternal characteristics, routine hematology, blood pressure (BP) status, type of delivery and length of stay were analyzed.Results: Type of delivery, maternal age, height, weight, body mass index (BMI), systolic blood pressure, diastolic blood pressure, length of stay, and routine hematologic profile except leukocytes showed statistically significant correlations with hypertension for the total 108 pregnant mothers. Pregnant mothers with caesarean delivery due to pregnancy induced hypertension (PIH) was threefold than those of normal blood pressure (95% confidence interval, 1.343-6.563). Statistical analyses indicated significant correlations between type of delivery and length of stay for pregnant mothers with hypertension after delivery (p-value = 0.000). Conclusion:On average, pregnant mothers who had hypertension with caesarean delivery spent at least 49-72 hours in the hospital after delivery. Indeed, the Royal College of Obstetricians and Gynecologists recommended that pregnant mothers with vaginal delivery should stay in a hospital for 1 or 2 days and those with caesarean section were suggested to stay 3 or 4 days after delivery. However, some pregnant mothers in this study spent shorter time to stay at the hospital after delivery. Therefore, it is suggested for pregnant mothers to stay at a hospital in a more sufficient period of time after delivery to give an adequate time for physicians to classify, to diagnose, or to treat complications after delivery.

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Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China

Cited by 20 publications

References 23 publications

Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China

Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China

Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study

Type of Delivery and Length of Stay in Hypertension Patients

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