Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)

Abstract

Obesity as measured by BMI is not associated with the development of incident UC or CD. Alternative measures of obesity are required to further investigate the role of obesity in the development of incident IBD.

Visceral Fat Is Increased in Individuals With Crohn’s Disease: A Comparative Analysis With Healthy Controls

“…In a prospective cohort study (EPIC cohort) of European adults, BMI was not associated with a specific phenotype of disease behaviour or disease location (13) as in the our study. This could be explained by the chronic status of CD in patients with stenosis as compared to luminal disease, what could explain the low BMI in this specific phenotype of patients.…”

The microbiota in inflammatory bowel disease

“…A large prospective study found no association between obesity and development of incident IBD [64]. This cohort had a predominance of middle-aged subjects, the median age being approximately 53 years.…”

Untitled

“…4 of 5 published studies [11,33,36,53,59] support this hypothesis in showing an association between regular physical activity and a reduced risk of developing CIBD Klein et al [36] questioned habitual physical activity in recent onset cases (53 UC and 33 CD), finding a low level of activity prior to the development of clinical disease. In 3 421 972 person years of follow-up in the Nurses Health Studies [33], 284 cases of CD and 363 cases of UC were identified.…”

“…In a second study, patients with medical or psychiatric abnormalities were excluded, and despite similar accelerometer readings, the patients had greater subjective and objective muscle fatigue than controls [67]. A third negative report [11] included more cases with UC than with CD, and diagnostic criteria were not standardized. In the fourth negative study [60], 23 % of those with CD reported greater fatigue, and 21 % noted reduced leisure activities, although a brief interview by the principal investigators had found similar proportions of patients and controls reporting high, moderate or low levels of physical activity Thus, a level of habitual physical activity that is lower than that of controls and below current minimum recommendations for general health is a relatively consistent finding in CIBD.…”