SUMMARY -Th e aim of this study was to investigate the controversial infl uence of anthropometry on clinical severity and prognosis of acute ST-elevation myocardial infarction (STEMI). We prospectively analyzed 250 patients with acute STEMI treated with primary percutaneous coronary intervention (September 2011 -September 2012. Th ey were grouped according to the following anthropometric parameters: body mass index (BMI) (<25.0, 25.0-29.9, ≥30.0 kg/m²), waist circumference (WC) (<102/88, ≥102/88 cm), waist-to-hip ratio (WHR) (<0.90/0.85, ≥0.90/0.85) and waistto-height ratio (WHtR) (<53/49, 53/49-62/57, ≥63/58). Th e groups were analyzed by baseline, as well as severity (clinical, laboratory, echocardiography, coronary angiography, in-hospital complications) and prognostic parameters (major adverse cardiovascular events and sick leave duration during 12-month follow up). Patients with BMI <25.0 kg/m 2 had the highest rates of dyspnea and those with BMI ≥30.0 kg/m² had the longest hospitalization and widest stents; patients with WHR ≥0.90/0.85 had higher rates of signifi cantly stenosed proximal/middle coronary segments, while those with WHtR ≥63/58 had the highest rates of heart failure and total in-hospital complications (p<0.05). BMI <25.0 kg/m 2 increased (odds ratio (OR) 2.00, confi dence interval (CI) [1.09-3.68], p=0.026) and BMI 25.0-29.9 kg/m 2 reduced (OR 0.52, CI [0.30-0.91], p=0.022) the risk of dyspnea; WHR ≥0.90/0.85 increased the risk of signifi cant proximal/middle coronary segment stenosis (OR 3.34,.86], p=0.029) and WHtR ≥63/58 the risk of heart failure (OR 2.05, CI [1.13-3.71], p=0.017) and total in-hospital complications (OR 1.94,], p=0.017) (p<0.05). In conclusion, WHR and WHtR are better anthropometric parameters than BMI in predicting acute STEMI severity, while WC has no infl uence on it. Anthropometry has no infl uence on prognosis.