Body Mass Index as an Indicator of Metabolic Disorders in Annual Health Checkups among Japanese Male Workers

Ohwaki, Kazuhiro; Yano, Eiji

doi:10.2486/indhealth.47.611

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…The proportion of both obese men and lean women in our study is consistent with that observed in subjects in the same-age groups in a recent national demographic survey [11]. However, some other epidemiologic studies performed in subjects belonging to the same age group as our subjects reported slightly different results [12,13]; in these two studies, the proportion of men with liver dysfunction observed in workers at a manufacturing company was lower than that in our study. These differences can be explained, at least partly, as being due to socioeconomic factors, including the type of work; in our study, 75.0 % of the male workers belonged to the service sector.…”

Section: Resultssupporting

confidence: 90%

Abnormality of risk factors for atherosclerotic disease among young Japanese aged 19–39 years old: an evaluation of health checkup data

Sasaki

Yoshida

Ohta

et al. 2012

Environ Health Prev Med

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Section: Resultssupporting

confidence: 90%

Abnormality of risk factors for atherosclerotic disease among young Japanese aged 19–39 years old: an evaluation of health checkup data

Sasaki

Yoshida

Ohta

et al. 2012

Environ Health Prev Med

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“…The majority of metabolic and anthropometric parameters (waist-hip ratio, fat body mass, total, and LDL cholesterol, triglycerides, glycated hemoglobin and HOMA index) correlated negatively with dopaminergic activity measured by apomorphine test. Since those parameters are known to be influenced by BMI and age [24,25], we recalculated the correlations between hormonal responses in apomorphine test and metabolic parameters after adjustment for age and BMI. After adjustment, negative correlations between AUC/PRL and total cholesterol (r = -0.41; p = 0.007; fig.…”

Section: Resultsmentioning

confidence: 99%

Central Dopaminergic Activity Influences Metabolic Parameters in Healthy Men

et al. 2012

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Background/Aims: Central dopaminergic activity is probably linked to regulation of glucose and lipid metabolism and weight maintenance. The aim of our study was to evaluate the relationship between central dopaminergic activity measured using the apomorphine challenge test and metabolic parameters in healthy men. Methods: Forty-two healthy men (average age 43.5 ± 7.4 years, body mass index, BMI, 27.4 ± 5.7) were examined anthropometrically and biochemically (glycemia, lipids, glycated hemoglobin). Central dopaminergic activity was assessed as the area under the curve (AUC) of prolactin (PRL) and growth hormone (GH) responses to the apomorphine challenge test after sublingual administration of apomorphine in a dose of 0.033 mg/kg. Insulin resistance was quantified by calculation of glucose disposal and metabolic clearance rate during a euglycemic hyperinsulinemic clamp on two insulin levels (1 and 10 mIU/kg/min). Linear regression was used for statistical analysis. Results: Hormonal responses correlated negatively with age (for AUC/GH r = -0.33; p = 0.031) and BMI (AUC/GH r = -0.41; p = 0.007). After adjustment for age and BMI, a statistically significant negative correlations between AUC/PRL and total cholesterol (r = -0.41; p = 0.007), AUC/GH and HbA1c (r = -0.37; p = 0.016) and AUC/GH and HOMA (homeostasis model assessment; r = -0.345; p = 0.025) were observed. Conclusion: Central dopaminergic activity declines with age and BMI. Higher total cholesterol, glycated hemoglobin and insulin resistance parameters are connected with lower central dopamine tone.

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“…Weight was measured without shoes or heavy clothes to the nearest 0.1 kg using standard calibrated scales. Systolic and diastolic blood pressure values were measured in the sitting position [21]. Blood was withdrawn after 8 hours of fasting and analyzed with standard methods in clinical laboratories under the nationally certified laboratory management system.…”

Section: Methodsmentioning

confidence: 99%

Japan Diabetes Outcome Intervention Trial-1(J-DOIT1), a nationwide cluster randomized trial of type 2 diabetes prevention by telephone-delivered lifestyle support for high-risk subjects detected at health checkups: rationale, design, and recruitment

et al. 2013

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BackgroundLifestyle modifications are considered the most effective means of delaying or preventing the development of type 2 diabetes (T2DM). To contain the growing population of T2DM, it is critical to clarify effective and efficient settings for intervention and modalities for intervention delivery with a wide population reach.The Japan Diabetes Outcome Intervention Trial-1 (J-DOIT1) is a cluster randomized controlled trial to test whether goal-focused lifestyle coaching delivered by telephone can prevent the development of T2DM in high-risk individuals in a real-world setting. This paper describes the study design and recruitment of the study subjects.MethodsFor the recruitment of study subjects and their follow-up annually over 3 years, we employed health checkups conducted annually at communities and worksites. Health care divisions recruited from communities and companies across Japan formed groups as a cluster randomization unit. Candidates for the study, aged 20-65 years with fasting plasma glucose (FPG) of 5.6-6.9 mmol/l, were recruited from each group using health checkups results in 2006. Goal-focused lifestyle support is delivered by healthcare providers via telephone over a one-year period. Study subjects will be followed-up for three years by annual health checkups. Primary outcome is the development of diabetes defined as FPG≥7.0 mmol/l on annual health checkup or based on self-report, which is confirmed by referring to medical cards.ResultsForty-three groups (clusters), formed from 17 health care divisions, were randomly assigned to an intervention arm (22 groups) or control arm (21 clusters) between March 2007 and February 2008. A total of 2840 participants, 1336 from the intervention and 1504 from the control arm, were recruited. Consent rate was about 20%, with no difference between the intervention and control arms. There were no differences in cluster size and characteristics of cluster between the groups. There were no differences in individual characteristics between the study arms.ConclusionWe have launched J-DOIT1, a nation-wide trial to prevent the development of T2DM in high-risk individuals using telephone-delivered intervention. This trial is expected to contribute to evidence-based real-world preventive practices.Trial registrationUMIN000000662.

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Body Mass Index as an Indicator of Metabolic Disorders in Annual Health Checkups among Japanese Male Workers

Cited by 12 publications

References 23 publications

Abnormality of risk factors for atherosclerotic disease among young Japanese aged 19–39 years old: an evaluation of health checkup data

Abnormality of risk factors for atherosclerotic disease among young Japanese aged 19–39 years old: an evaluation of health checkup data

Central Dopaminergic Activity Influences Metabolic Parameters in Healthy Men

Japan Diabetes Outcome Intervention Trial-1(J-DOIT1), a nationwide cluster randomized trial of type 2 diabetes prevention by telephone-delivered lifestyle support for high-risk subjects detected at health checkups: rationale, design, and recruitment

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