Body mass index at adolescence and risk of noncardia gastric cancer in a cohort of 1.79 million men and women

Levi, Zohar; Kark, Jeremy D.; Twig, Gilad; Katz, Lior H.; Leiba, Adi; Derazne, Estela; Tzur, Dorit; Liphshitz, Irena; Keinan‐Boker, Lital; Afek, Arnon

doi:10.1002/cncr.31049

Cited by 15 publications

(10 citation statements)

References 39 publications

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“…15 In another study, obesity was significantly associated with the risk of noncardia gastric cancer. 15,16 In this study, BMI was significantly higher in re-ESD than surgery group (OR, 0.744; 95% CI, 0.563 to 0.983; p=0.037), which showed similar result with previous studies in that higher BMI was significantly associated with less aggressive histology of MGC.…”

Section: Discussionsupporting

confidence: 86%

Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer

Kim

et al. 2020

Gut and Liver

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Background/Aims: Patients treated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) are at risk of developing metachronous gastric cancer (MGC). The aim of this study was to evaluate the clinical outcomes of MGC after ESD for EGC between the re-ESD and surgery groups. Methods: In total, data from 1,510 patients who underwent ESD for EGC from January 2005 to May 2014 were retrospectively reviewed, and data from 112 patients with MGC were analyzed according to the type of treatment, namely, re-ESD and surgery. The clinicopathological factors affecting the subsequent treatment and outcomes of MGC were evaluated. Results: The median duration to the development of MGC was 47 months. In multivariate analysis, lower body mass index (BMI) (p=0.037) and multiplicity (p=0.014) of index cases were significantly associated with subsequent surgery for MGC. In cases of MGC, a diffuse or mixed-type Lauren classification (p=0.009), the depth of tumor mucosal invasion (p=0.001), and an upper stomach location (p=0.049) were associated with surgery. Overall survival was significantly shorter in the surgery group than in the re-ESD group after treatment for MGC (log-rank test, p=0.01). Conclusions: Lower BMI and multiplicity of index cancers were significantly associated with the surgical resection of MGC. Close follow-up is needed to minimize additional treatment for cases at high risk of advanced MGC after ESD for EGC.

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Section: Discussionsupporting

confidence: 86%

Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer

Kim

et al. 2020

Gut and Liver

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“…Finally, our broad occupational category was not designed to detect occupational exposure and differed from occupational categories to detect specific occupational exposure . In addition, we could not assess multiple primary cancer cases or other possible risk factors (overweight, diet, institutional place‐based discrimination, physical activity, and cancer screening program) . Therefore, future studies are warranted to integrate all these aspects of cancer causal pathways.…”

Section: Discussionmentioning

confidence: 99%

Occupational class and male cancer incidence: Nationwide, multicenter, hospital‐based case–control study in Japan

Zaitsu

Kaneko

Takeuchi³

et al. 2019

Cancer Medicine

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Little is known about socioeconomic inequalities in male cancer incidence in nonwestern settings. Using the nationwide clinical and occupational inpatient data (1984‐2016) in Japan, we performed a multicentered, matched case–control study with 214 123 male cancer cases and 1 026 247 inpatient controls. Based on the standardized national classifications, we grouped patients’ longest‐held occupational class (blue‐collar, service, professional, manager), cross‐classified by industrial cluster (blue‐collar, service, white‐collar). Using blue‐collar workers in blue‐collar industries as the referent group, odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by conditional logistic regression with multiple imputation, matched for age, admission date, and admitting hospital. Smoking and alcohol consumption were additionally adjusted. Across all industries, a reduced risk with higher occupational class (professionals and managers) was observed for stomach and lung cancer. Even after controlling for smoking and alcohol consumption, the reduced odds persisted: OR of managers in white‐collar industries was 0.80 (95% CI 0.72‐0.90) for stomach cancer, and OR of managers in white‐collar industries was 0.66 (95% CI 0.55‐0.79) for lung cancer. In white‐collar industries, higher occupational class men tended to have lower a reduced risk for most common types of cancer, with the exception of professionals who showed an excess risk for prostate cancer. We documented socioeconomic inequalities in male cancer incidence in Japan, which could not be explained by smoking and alcohol consumption.

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“…Individuals with atrophic gastritis might experience changes in appetite and dietary habits; therefore, given the cross-sectional design of our and others’ studies,20 40 we cannot rule out the possibility of reverse causation as an explanation for discrepant findings. A large prospective study among males in Israel showed that obesity at adolescence to be positively related to increased risk of non-cardia gastric cancer 41…”

Section: Discussionmentioning

confidence: 99%

Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study

et al. 2019

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ObjectiveUnderstanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence.MethodsIn a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland), Helicobacter pylori serum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25–78 years, randomly selected from Israel’s population registry in age–sex and population strata. Multivariable logistic regression analyses were performed.ResultsUsing cut-offs of PGI <30µg/L or PGI:PGII <3.0, the prevalence of atrophic gastritis was higher among Arab than Jewish participants: 8.8% (95% CIs 7.2% to 10.8%) vs 5.9% (95% CI 4.4% to 7.9%), increasing with age in both groups (p<0.001 for trend). Among Jewish participants, infection with H. pylori CagA phenotype was positively related to atrophic gastritis: adjusted OR (aOR) 2.16 (95% CI 0.94 to 4.97), but not to non-CagA infections aOR 1.17 (95% CI 0.53 to 2.55). The opposite was found among Arabs: aOR 0.09 (95% CI 0.03 to 0.24) for CagA positive and aOR 0.15 (95% CI 0.06 to 0.41) for Cag A negative phenotypes (p<0.001 for interaction). Women had a higher atrophic gastritis prevalence than men. Obesity and smoking were not significantly related to atrophic gastritis; physical activity tended to be inversely associated in Arabs (p=0.08 for interaction).ConclusionsThe prevalence of atrophic gastritis was higher among Arabs than Jews and was differently associated with the CagA phenotype.

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Body mass index at adolescence and risk of noncardia gastric cancer in a cohort of 1.79 million men and women

Cited by 15 publications

References 39 publications

Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer

Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer

Occupational class and male cancer incidence: Nationwide, multicenter, hospital‐based case–control study in Japan

Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study

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