Body Mass Index Course in Asymptomatic HIV-Infected Homosexual Men and the Predictive Value of a Decrease of Body Mass Index for Progression to AIDS

Maas, Jolanda; Dukers, Nicole H. T. M.; Krol, Anneke; Ameijden, E. J. Van; Leeuwen, R. van; Roos, M. T. L.; Wolf, F de; Coutinho, Roel A.; Keet, I. P. M.

doi:10.1097/00042560-199811010-00007

Cited by 33 publications

(22 citation statements)

References 16 publications

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“…Although the cocaine group was younger than the other drug use groups and those not using drugs, BMI was still significantly lower in this group, suggesting that the use of this particular drug may directly affect the metabolism or food intake patterns of active users. Although CD4+ cell count is an important influence on BMI in this and previous studies (Batterham et al, 2002;Jones et al, 2003;Maas et al, 1998;Shor-Posner et al, 2000;Zachariah et al, 2006), our data show that CD4 cell counts were similar among the different drug use groups and did not explain the lower BMI among the cocaine users.…”

Section: Discussioncontrasting

confidence: 77%

Drug use and other risk factors related to lower body mass index among HIV-infected individuals

Quach

Wanke

Schmid

et al. 2008

Drug and Alcohol Dependence

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Malnutrition is associated with morbidity and mortality in HIV infected individuals. Little research has been conducted to identify the roles that clinical, illicit drug use and socioeconomic characteristics play in the nutritional status of HIV-infected patients. This cross-sectional analysis included 562 HIV-infected participants enrolled in the Nutrition for Healthy Living study conducted in Boston, MA and Providence, RI. The relationship between body mass index (BMI) and several covariates (type of drug use, demographic, and clinical characteristics) were examined using linear regression.Overall, drug users had a lower BMI than non-drug users. The BMI of cocaine users was 1.4 kg/ m 2 less than that of patients who did not use any drugs, after adjusting for other covariates (p= 0.02). The BMI of participants who were over the age of 55 years was 2.0 kg/m 2 less than that of patients under the age of 35, and BMI increased by 0.3 kg/m 2 with each 100 cells/mm 3 increase in CD4 count. HAART use, adherence to HAART, energy intake, AIDS status, hepatitis B and hepatitis C co-infections, cigarette smoking and depression were not associated with BMI in the final model.In conclusion, BMI was lower in drug users than non-drug users, and was lowest in cocaine users. BMI was also directly associated with CD4 count and inversely related to age more than 55 years old. HIV infected cocaine users may be at higher risk of developing malnutrition, suggesting the need for anticipatory nutritional support.

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Section: Discussioncontrasting

confidence: 77%

Drug use and other risk factors related to lower body mass index among HIV-infected individuals

Quach

Wanke

Schmid

et al. 2008

Drug and Alcohol Dependence

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“…[3][4][5] These conditions were often used as indicators of advanced disease, and their connection with AIDS was a constant reminder of the fatal and transmissible nature of the disease that these patients were carrying. 6,7 The situation changed with the introduction of HAART, which markedly reduced opportunistic infections and HIVrelated morbidity and mortality, as well as the outward signs associated with the development of AIDS. 8,9 On the other hand, the transformation of this fatal disease into a chronic illness led to the emergence of metabolic complications secondary to long-term HAART use.…”

mentioning

confidence: 99%

Prevalence and Impact of Body Physical Changes in HIV Patients Treated with Highly Active Antiretroviral Therapy: Results from a Study on Patient and Physician Perceptions

Cabrero

Griffa

Burgos

2010

AIDS Patient Care and STDs

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Patients infected with HIV treated with highly active antiretroviral therapy (HAART) frequently develop body physical changes (BPC) that have an important psychosocial burden. The purpose of this study was to determine the prevalence of BPC observed by HIV-infected patients and their attending physicians and to assess the impact BPC had on daily life. In this epidemiologic multicenter study, patients with HIV infection and their treating physicians filled out parallel questionnaires about their perceptions of specific BPC and their impact on daily activities. A total of 965 patient-physician questionnaires were collected across 98 health centers. Patient's mean age was 43.7 AE 8.5 years and 72.6% were men. Adjusted prevalence of perceived BPC by patients and physicians was 55.1% (95% confidence interval [CI]: 52.0-58.1) and 55.2% (95% CI: 52.1-58.2), respectively ( p ¼ 1.000). Overall patient-physician agreement concerning perception of BPC was 83% ( p < 0.0005). The most common BPC was lipoatrophy, described by 46.8% (95% CI: 43.7-49.8) of patients and 49.4% (95% CI: 46.3-52.5) of physicians ( p ¼ 0.033) followed by lipohypertrophy. No gender differences were observed in the global prevalence of BPC ( p ¼ 0.649). However, significantly more women reported lipoatrophy of the lower limbs ( p ¼ 0.009) and buttocks ( p ¼ 0.007), as well as lipohypertrophy ( p ¼ 0.007), than men; 58.2% (95% CI: 54.0-62.4) patients noted that BPC negatively affected their daily activities. This study reflects the high prevalence of patient and physicianperceived BPC in the HIV population, and the adverse impact on daily life. Physicians should be aware of the psychosocial consequences of BPC in HIV patients in order to improve patient well-being.

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“…Several authors (22,23,25,53) As outlined at the beginning of this review, the intestinal microbiota is altered by HIV-1 infection, either directly or indirectly, or even by the therapeutic regimen employed.…”

Section: Nutritional Status and Intestinal Microbiota In Hiv-1 Infectionmentioning

confidence: 99%

Intestinal microbiota and HIV-1 infection

Trindade¹,

Souza²,

Lopes³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The intestinal microbiota consists of a qualitatively and quantitatively diverse range of microorganisms dynamically interacting with the host. It is remarkably stable with regard to the presence of microorganisms and their roles which, however, can be altered due to pathological conditions, diet composition, gastrointestinal disturbances and/or drug ingestion. The present review aimed at contributing to the discussion about changes in the intestinal microbiota due to HIV-1 infection, focusing on the triad infection-microbiota-nutrition as factors that promote intestinal bacterial imbalance. Intestinal microbiota alterations can be due to the HIV-1 infection as a primary factor or the pharmacotherapy employed, or they can be one of the consequences of the disease.

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Body Mass Index Course in Asymptomatic HIV-Infected Homosexual Men and the Predictive Value of a Decrease of Body Mass Index for Progression to AIDS

Cited by 33 publications

References 16 publications

Drug use and other risk factors related to lower body mass index among HIV-infected individuals

Drug use and other risk factors related to lower body mass index among HIV-infected individuals

Prevalence and Impact of Body Physical Changes in HIV Patients Treated with Highly Active Antiretroviral Therapy: Results from a Study on Patient and Physician Perceptions

Intestinal microbiota and HIV-1 infection

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