Body Mass Index, Follicle-Stimulating Hormone and their Predictive Value in vitro Fertilization

Stelea, Lavinia; Petre, Ion; Craina, Marius; Vlaicu, Brigitha; Sisu, Alina Maria; Pop, Elena; Moleriu, Radu Dumitru; Ivan, Mihaela; Novák, Tibor; Fulger, Lazar

doi:10.37358/rc.18.7.6428

Cited by 2 publications

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“…The LV dysfunction is evident in almost half of ESRD patients starting dialysis and can be induced by hemodialysis itself [6,29,31,32]. Furthermore, we underline the need for more, dynamic, complex, experimental large, randomized protocols, which may have general and cardiovascular implications [33][34][35][36][37][38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

Predictive Value of Several Echo Parameters for Cardiovascular Events in Hemodialysis Patients with Mid-range and Preserved Ejection Fraction Heart Failure

Ivan¹,

Albulescu²,

Albulescu³

et al. 2019

Rev. Chim.

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Patients with end stage renal disease (ESRD) on hemodialysis (HD) are predisposed to higher rates of major cardiovascular events, through several well-known pathophysiological mechanisms. The rates of all-cause mortality are 6 to 10fold greater for these patients compared with general population. Furthermore, diabetes mellitus, history of cardiovascular disease, dialysis duration, and residual diuresis are factors related to cardiovascular events in hemodialysis. Whilst structural and functional echocardiographic abnormalities in dialyzed patients have been the surrogate for several survival studies, the predictive value of these echo parameters, are not clearly established in this field .In dialysis patients, it is still unclear which echo parameter is the best in determining cardiovascular outcome. The purpose of our study was to investigate the role of Doppler Echocardiography and Tissue Doppler Imaging (TDI) abnormalities, in providing predictive parameters for this particular population. The survival rates were analyzed by Kaplan�Meier curves and cardiac events predictors by Cox�s proportional-hazards model. We found correlations between several echo measurements and cardiovascular events, especially diastolic dysfunction and impaired left ventricular parameters. We strongly recommend the use of these echocardiographic parameters in early detection of patients at high risk in order to reduce morbidity and mortality.

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Section: Resultsmentioning

confidence: 99%

Predictive Value of Several Echo Parameters for Cardiovascular Events in Hemodialysis Patients with Mid-range and Preserved Ejection Fraction Heart Failure

Ivan¹,

Albulescu²,

Albulescu³

et al. 2019

Rev. Chim.

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“…Many women refer to an endocrinologist or gynecologist when they trying to conceive and not succeed. In this case, after pharmacological treatment fails, they try invasive procedures and even in vitro fertilization [4,5]. Nonetheless, important steps were made regarding the impact of metabolic comorbidities in PCOS women.…”

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confidence: 99%

Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance

Vonica¹,

Fodor²,

Román³

et al. 2019

Rev. Chim.

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The aim of the paper is to detect insulin resistance (IR) biomarkers via metabolomics. It is important to understand the PCOS pathophysiology, diagnosis measures and, subsequently, to improve treatment type and time of IR in PCOS. In most cases, almost half of the women with PCOS have IR which is triggered by inflammation, glucotoxicity and lipotoxicity. In this work was conducted a systematic review of all the papers that used metabolomics for detecting IR biomarkers in PCOS women. The exclusion criteria were: reviews, study population with women bellow 18 years of age, studies including animals and articles not in English, remaining 4 records. The results from the literature shown that phosphatidylcholines were decreased in IR PCOS women when compared to controls. Nonetheless, trans-2-hexenoylcoa, linoleic acid, leucine, myristic acid and palmitic acid regarding lipid metabolism and tyrosine, lysine, phenylalanine a-aminoadipic acid regarding amino acid metabolism were also corelated to IR in PCOS women when compared with healthy or IR controls. Lactate was the only increased metabolite related to glucose metabolism in IR PCOS women. Metabolic alteration in PCOS women with IR when are compared with controls and results that those are brought by both PCOS and IR. Lyso-phosphatidylcholine have an important pro-inflammatory and altered insulin signaling effect, both alterations being considered hallmarks of PCOS women. Serine hyperphosphorylation of the receptor accentuates IR by decreasing the signaling of insulin receptor. Moreover, high levels of lactate correlated with IR in PCOS women may indicate high muscle glycolysis, hepatic glucose production and peripheral glucose uptake. IR biomarkers in PCOS women were evidenced by metabolomics technique.

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Body Mass Index, Follicle-Stimulating Hormone and their Predictive Value in vitro Fertilization

Cited by 2 publications

References 0 publications

Predictive Value of Several Echo Parameters for Cardiovascular Events in Hemodialysis Patients with Mid-range and Preserved Ejection Fraction Heart Failure

Predictive Value of Several Echo Parameters for Cardiovascular Events in Hemodialysis Patients with Mid-range and Preserved Ejection Fraction Heart Failure

Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance

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