Body mass index had different effects on premenopausal and postmenopausal breast cancer risks: a dose-response meta-analysis with 3,318,796 subjects from 31 cohort studies

Chen, Yanzi; Liu, Li; Zhou, Quan; Imam, Mustapha Umar; Cai, Jialin; Wang, Yaxuan; Qi, Minjie; Ping, Zhiguang; Fu, Xiaoli

doi:10.1186/s12889-017-4953-9

Cited by 87 publications

(72 citation statements)

References 59 publications

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“…Studies have shown a positive association between BMi and an increased incidence of breast cancer in postmenopausal women. no positive correlation was found in premenopausal European women between BMi and breast cancer (34).…”

Section: Obesity and Cancermentioning

confidence: 82%

Obesity induces DNA damage

Ştefani¹,

Totan²,

Miricescu³

et al. 2019

Ro Med J.

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A diet rich in saturated lipids, refined carbohydrates associated with a sedentary lifestyle leads to obesity in both adults and children. Obesity is associated with the existence of a chronic inflammatory process, that will further lead to systemic oxidative stress and DNA oxidative damage. There is currently a positive correlation between obesity and cancer due to nuclear but also mitochondrial DNA injury. Obesity is a risk factor for the development of several types of cancer such as breast, prostate or colorectal. The purpose of this review is to present the effects of obesity on human body, by describing the chronic inflammatory process, oxidative stress, and the molecular mechanisms involved in cancer progression.

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Section: Obesity and Cancermentioning

confidence: 82%

Obesity induces DNA damage

Ştefani¹,

Totan²,

Miricescu³

et al. 2019

Ro Med J.

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“…With regard to reproductive stage, there appears to be convincing evidence of a positive association between obesity and increased risk of post‐menopausal BC (Chen et al, ; Chen et al, ; Munsell et al, ; Xia et al, ). Interestingly, stratification by hormone receptor status suggests a consistent positive association for ERα+/PR+ BC, but no trend for ERα−/PR− cases (Munsell et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Taken together, these results indicate that obesity may influence the risk of pre‐menopausal BC based on hormone receptor status. In post‐menopausal women, epidemiological studies consistently report a positive association between BC and obesity (Chen et al, ; Chen et al, ; Munsell et al, ; Xia et al, ). An overweight (>25 kg·m −2 ) and obese (>30 kg·m −2 ) BMI are positively associated with BC incidence (Xia et al, ).…”

Section: Adiposity and Bcmentioning

confidence: 99%

“…In pre-menopausal women, two meta-analyses have identified inverse associations between BC risk and obesity (Chen et al, 2017;Munsell, Sprague, Berry, Chisholm, & Trentham-Dietz, 2014). Stratification by hormone receptor status suggests that this inverse association is specific for ERα+/PR+ tumours (Munsell et al, 2014).…”

Section: Pre-menopausal Versus Post-menopausal Bcmentioning

confidence: 99%

“…Positive associations between high‐fat diets (HFD) and BC incidence have been documented in observational and preclinical studies (Boyd et al, ; Cao, Hou, & Wang, ; Liu et al, ; Nguyen et al, ; Wu, Yu, Tseng, Stanczyk, & Pike, ). Moreover, obesity is considered a BC risk factor and may influence BC survival (Chen et al, ; Chen et al, ; Pierobon & Frankenfeld, ; Xia et al, ). Both dietary fats and obesity influence various epigenetic signatures associated with BC.…”

Section: Introductionmentioning

confidence: 99%

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Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Donovan

Wren

Cenker

et al. 2020

British J Pharmacology

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Breast cancer (BC) is the most common cancer and second leading cause of cancer mortality in women worldwide. Validated biomarkers enhance efforts for early detection and treatment, which reduce the risk of mortality. Epigenetic signatures have been suggested as good biomarkers for early detection, prognosis and targeted therapy of BC. Here, we highlight studies documenting the modifying effects of dietary fatty acids and obesity on BC biomarkers associated with DNA methylation. We focus our analysis on changes elicited in writers of DNA methylation (i.e., DNA methyltransferases), global DNA methylation and gene‐specific DNA methylation. To provide context, we precede this discussion with a review of the available evidence for an association between BC incidence and both dietary fat consumption and obesity. We also include a review of well‐vetted BC biomarkers related to cytosine‐guanine dinucleotides methylation and how they influence BC risk, prognosis, tumour characteristics and response to treatment. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Changes in weight and waist circumference during menopausal transition and postmenopausal breast cancer risk

Park

2021

Intl Journal of Cancer

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Our study aimed to investigate the association between changes in weight and waist circumference (WC) during menopausal transition and breast cancer risk in Asian women. In total, 184 931 women aged 40 to 59 years with a premenopausal status at the first screening in 2009 to 2010 and a postmenopausal status at the second screening in 2011 to 2012 were included in the analysis. Changes in weight and WC during menopausal transition were classified as loss (>2.5 kg; >2.5 cm), stable (±2.5 kg; ±2.5 cm), and gain (2.5‐4.9 kg, ≥5 kg; 2.5‐4.9 cm, ≥5 cm). WC gain of 5 cm or more during menopausal transition was associated with an increased risk of breast cancer with an HR of 1.15 (95% CI = 1.01‐1.30), compared to stable WC (±2.5 cm). Among obese premenopausal women, increased WC ≥5 cm during menopausal transition was associated with increased breast cancer risk with an HR of 1.22 (95% CI = 1.03‐1.44). Similarly, in women with premenopausal WC ≥80 cm, increased WC of ≥5 cm during menopausal transition was likely to increase the breast cancer risk (HR = 1.36, 95% CI = 1.13‐1.88) than in women with stable WC. However, in premenopausal women with BMI <23 kg/m2 or WC <80 cm, changes in WC during menopausal transition did not show an association. Weight gain during menopausal transition was not associated with the risk of breast cancer. Changes in central obesity during menopausal transition in combination with premenopausal obesity status are associated with breast cancer risk after menopause.

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Body mass index had different effects on premenopausal and postmenopausal breast cancer risks: a dose-response meta-analysis with 3,318,796 subjects from 31 cohort studies

Cited by 87 publications

References 59 publications

Obesity induces DNA damage

Obesity induces DNA damage

Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Changes in weight and waist circumference during menopausal transition and postmenopausal breast cancer risk

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