Body mass index in male Caucasian veterans with or without posttraumatic stress disorder

Kozarić‐Kovačić, Dragica; Ilić, Mirjana; Romić, Željko; Vidovic, Andjelko; Jendričko, Tihana; Pivac, Nela

doi:10.1016/j.pnpbp.2009.07.026

Cited by 22 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, a prior study did find this association among US male veterans of the Vietnam War; 84% of those with PTSD were overweight or obese, which is much higher than the rate in the general population. 19 A study in Germany reported that PTSD was associated with obesity among women, but not men, in both cross-sectional and longitudinal analyses, 20 whereas a study of Croatian male veterans found no association between PTSD and obesity, 21 similar to our findings. One possible explanation for differences in findings between studies is a difference in the populations studied.…”

Section: Discussionsupporting

confidence: 84%

The Association of Posttraumatic Stress Disorder with Fast Food and Soda Consumption and Unhealthy Weight Loss Behaviors Among Young Women

Hirth

Rahman²,

Berenson³

2011

Journal of Women's Health

View full text Add to dashboard Cite

Objective: This study examines the association of posttraumatic stress disorder (PTSD) symptoms with fast food and soda consumption, unhealthy dieting behaviors, and body mass index (BMI) in a group of young women. Methods: This study was conducted on cross-sectional data gathered from 3181 females 16-24 years of age attending five publicly funded clinics in Texas. The associations among PTSD, fast food consumption frequency, soda consumption frequency, unhealthy dieting behaviors, and BMI were examined using binary and ordinal logistic regression. Results: PTSD symptoms were associated with an increased frequency of consumption of fast food and soda as well as unhealthy dieting behaviors but not with increased body mass index (BMI). Conclusions: PTSD symptoms adversely affect both eating and dieting behaviors of young women. These behaviors may have negative long-term consequences for the health of females with PTSD symptoms.

show abstract

Section: Discussionsupporting

confidence: 84%

The Association of Posttraumatic Stress Disorder with Fast Food and Soda Consumption and Unhealthy Weight Loss Behaviors Among Young Women

Hirth

Rahman²,

Berenson³

2011

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

“…In our previous study on another sample of PTSD patients from the same area (meaning similar lifestyle and dietary habits), we found no difference between PTSD patients and healthy controls regarding BMI ( 100 ). Both groups were slightly overweight in line with the study encompassing a larger sample of Croatian war veterans with PTSD and without PTSD in comparison to a nation-wide civilian sample ( 101 ). Considering all this, we presume that BMI did not have large effect on the comparison of variables known to be affected by BMI.…”

Section: Discussionsupporting

confidence: 68%

Circulating Levels of Hormones, Lipids, and Immune Mediators in Post-Traumatic Stress Disorder – A 3-Month Follow-Up Study

et al. 2015

View full text Add to dashboard Cite

A number of peripheral blood analytes have been proposed as potential biomarkers of post-traumatic stress disorder (PTSD). Few studies have investigated whether observed changes in biomarkers persist over time. The aim of this study was to investigate the association of combat-related chronic PTSD with a wide array of putative PTSD biomarkers and to determine reliability of the measurements, i.e., correlations over time. Croatian combat veterans with chronic PTSD (n = 69) and age-matched healthy controls (n = 32), all men, were assessed at two time points separated by 3 months. Serum levels of lipids, cortisol, dehydroepiandrosterone-sulfate (DHEA-S), prolactin, and C-reactive protein were determined. Multiplex assay was used for the simultaneous assessment of 13 analytes in sera: cytokines [interferon-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, TNF-α], adhesion molecules (sPECAM-1, sICAM-1), chemokines (IL-8 and MIP-1α), sCD40L, nerve growth factor, and leptin. Group differences and changes over time were tested by parametric or non-parametric tests, including repeated measures analysis of covariance. Reliability estimates [intraclass correlation coefficient (ICC) and kappa] were also calculated. Robust associations of PTSD with higher levels of DHEA-S [F(1,75) = 8.14, p = 0.006)] and lower levels of prolactin [F(1,75) = 5.40, p = 0.023] were found. Measurements showed good to excellent reproducibility (DHEA-S, ICC = 0.50; prolactin, ICC = 0.79). Serum lipids did not differ between groups but significant increase of LDL-C after 3 months was observed in the PTSD group (t = 6.87, p < 0.001). IL-8 was lower in the PTSD group (t = 4.37, p < 0.001) but assessments showed poor reproducibility (ICC = −0.08). Stable DHEA-S and prolactin changes highlight their potential to be reliable markers of PTSD. Change in lipid profiles after 3 months suggests that PTSD patients may be more prone to hyperlipidemia. High intra-individual variability in some variables emphasizes the importance of longitudinal studies in investigations of PTSD biomarkers.

show abstract

“…On the other hand, our finding that PTSD is associated with lower BMI classes is somewhat unusual. Some studies in veterans with combat PTSD have shown no relationship between BMI and PTSD (24), and many in those with childhood trauma have shown a positive association (25, 26), especially in women. Shame and concern related to overweight has been shown to be similar to other kinds of social anxiety (27), and may explain the greater rates we found in the higher BMI classes in COMED.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Obesity and Depression

Toups

Myers

Wisniewski

et al. 2013

Psychosomatic Medicine

View full text Add to dashboard Cite

Objective Obesity and Major Depressive Disorder (MDD) often co-occur. However, differences between obese and normal-weight depressed patients and the moderating effect of obesity on antidepressant treatment outcome have not been well studied. Methods 662 subjects in the COmbining Medications to Enhance Depression Outcomes (COMED) were randomized to treatment with escitalopram plus placebo, bupropion plus escitalopram, or venlafaxine plus mirtazapine for a 12 week primary treatment phase and 16 week follow-up. Body Mass Index (BMI) was calculated at baseline. Subjects were divided into BMI classes according to World Health Organization criteria: 1) normal (and low) weight (NW), 2) overweight (OW), 3) obese I (OB1) and 4) obese II+ (OB2). Clinical characteristics were compared using Chi-squared or Kruskall-Wallis testing. Outcomes were assessed using a repeated effects model, unadjusted and adjusted for baseline variables differing across BMI classes. Results 31.4% of the subjects were normal weight; 46.2% were obese. Higher BMI was associated with greater medical illness (p<0.001), social phobia (p=0.003) and bulimia (p=0.026). Lower BMI was associated with higher rates of Post Traumatic Stress Disorder (p=0.002) and drug abuse. Treatment outcomes, including remission, did not differ across classes. However, lower BMI was associated with more frequent (p=0.024, unadjusted, 0.053 adjusted) and more severe (p=0.008 unadjusted, 0.053 adjusted) side effects. Conclusions We found a high rate of obesity compared to the general population and significant differences in presentation and comorbidity, but not medication use and antidepressant outcomes, in subjects across BMI classes. Lower BMI classes had higher rates of comorbidities associated with poor outcome, which may have obscured outcome differences. Trial Registration clinicaltrials.gov Identifier: NCT 00270647

show abstract

Body mass index in male Caucasian veterans with or without posttraumatic stress disorder

Cited by 22 publications

References 28 publications

The Association of Posttraumatic Stress Disorder with Fast Food and Soda Consumption and Unhealthy Weight Loss Behaviors Among Young Women

The Association of Posttraumatic Stress Disorder with Fast Food and Soda Consumption and Unhealthy Weight Loss Behaviors Among Young Women

Circulating Levels of Hormones, Lipids, and Immune Mediators in Post-Traumatic Stress Disorder – A 3-Month Follow-Up Study

Relationship Between Obesity and Depression

Contact Info

Product

Resources

About