Body Mass Index in Thalassemia Children

Dey, Pranoy; Konwar, Gitashree; Sarkar, Bikash

doi:10.14260/jemds/2019/341

Cited by 5 publications

(6 citation statements)

References 6 publications

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“…In the current study it was found that BMI was significantly lower in Patient group than control group. This is in agreement with Dey, Konwar, Sarkar [11] who found that underweight (Low BMI) was a common finding in thlalassemia patients specially when they were older than 10 years of age.…”

Section: Discussionsupporting

confidence: 92%

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Study of Insulin Hormone Level and β-Cell Function in Children with β-Thalassemia Major

AbdElkawy¹,

Elrifaey²,

Mabrok³

et al. 2022

JAMMR

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Background: Diabetes and Impaired Glucose Tolerance are amajor complication of iron overload in patients with beta thalassemia major. Aim: To study the serum level of Insulin hormone and beta cell function in β- Thalassemia major patients. Methods: This study was carried out on 50 children that were divided into:- Group (1): thirty child with beta thalassemia with age ranged between (5 to 10 years), Group (2): Twenty apparently healthy matched age children were also included as control group. Both groups were subjected to history taking, full clinical examination, anthropometric measures, laboratory investigation that included:-, complete blood picture, Serum iron, serum ferriten,fasting serum glucose, 2h postprandial serum glucose, fasting serum insulin by ELISA(Sandwish assay procedure.) IRI, BFI. Results: There was highly statistical significant difference between the patient and control groups in the insulin resistance index (IRI), but there was decrease in beta cell function index (BFI) in patients group with no significantdifference. Conclusion: Thalassemic child is at risk of IR which is responsible for abnormalities in glucose metabolism so proper management and regular follow up is necessary to early diagnosis and prevention of complications.

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Section: Discussionsupporting

confidence: 92%

“…The cause of under nutrition in thalassemia major patients is multifactorial. Endocrinopathies including hypothyroidism, hypo-gonadotropic gonadism, growth hormone deficiency, hypoparathyroidism are the major causes of under nutrition in these patients [11].…”

Section: Discussionmentioning

confidence: 99%

Study of Insulin Hormone Level and β-Cell Function in Children with β-Thalassemia Major

AbdElkawy¹,

Elrifaey²,

Mabrok³

et al. 2022

JAMMR

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“…They found that 48.2% were malnourished with a mean BMI of 13.9 ± 1.6 kg/m 2 . TM has a significant impact on the growth process of children, and hence early intervention is needed to reduce the prevalence of malnutrition as good nutrition with adequate vitamin and trace element intake, along with calcium and vitamin D supplementation, side by side with optimal iron chelating therapy [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, pre-diabetic states are also at increased risk of cardiovascular disease [ 31 ]. Endocrine abnormalities should be monitored carefully, and a thorough endocrine evaluation should be carried out yearly in every patient with TM to detect subclinical endocrinopathies [ 26 ]. Early identification and treatment of persons with prediabetes has the potential to reduce or delay the progression to diabetes [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Detection of endocrine disorders in young children with multi-transfused thalassemia major

2021

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Background Beta thalassemia major (TM) is the most common inherited genetic disorder worldwide. Patients are at risk of iron overload, which leads to various forms of tissue damage, including endocrinopathies. The aim of this study was to evaluate the prevalence and risk factors of endocrine disorders in young patients with multi-transfused TM receiving iron chelation therapy. Methods The inclusion criteria included all known cases of TM according to hemoglobin electrophoresis data, aged 12 years or younger, during the study period. The patient’s age, gender, parent’s consanguinity, clinical examination, and types of iron chelating agents used were recorded. Serum ferritin level, complete blood count (CBC), blood glucose homeostasis, thyroid, and parathyroid functions were determined. Results One hundred twenty patients met the inclusion criteria; 70% of them had malnutrition. The presence of endocrine disorders was observed in 28/120 (23.33%) patients. The most common endocrine disorders were thyroid disorders, either subclinical or clinical hypothyroidism in 11/120 (9.17%) patients, followed by abnormalities in glucose homeostasis 9/120 (7.5%). The prevalence of impaired glucose tolerance, impaired fasting glucose, and diabetes mellitus in the present study was 5 (4.17%), 4 (3.33%), and 0 (00%), respectively, while the least frequent endocrine disorder seen in our patients was hypoparathyroidism in 8/120 (6.66%). We noted that high serum ferritin levels and poor patient compliance to therapy were significantly associated with increased endocrine disorders (OR 0.98, 95% CI 0.96–0.99, P = 0.003 and OR 0.38, 95% CI 0.16:0.93, P = 0.03, respectively). Combined chelating iron agents significantly decreased the prevalence of endocrine disorders when compared with monotherapy (OR 0.40, 95% CI 0.16:0.97, P = 0.04). Conclusion Endocrine disorders could occur in TM patients early before or equal to 12 years of life in about one-fourth of the patients. A high serum ferritin level and poor patient compliance to therapy were significantly associated with increased endocrine disorders. Combined iron-chelating agents were associated with a decreased prevalence of endocrine disorders when compared with monotherapy.

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“…According to WHO classification, anaemia is defined as a condition where the erythrocytes number or the haemoglobin levels are under the normal average. WHO considered about 42% of the world's children aged 5 years old and 40% of pregnant women as anaemic [16]. Severity of anaemia categorized into three groups: mild with haemoglobin level of 11-11.9 g/dL; moderate (8-10.9 g/dL) and lastly the severe level of anaemia which ranges less than 8 g/dL [9].…”

Section: Figure 2 Transfusion Requirement In Non-transfusion-dependen...mentioning

confidence: 99%

Malaysian socio-demographic characteristics, mean haemoglobin levels and BMI distribution of the monthly transfused group (MTG) and non-monthly transfused group (NMTG) thalassemia patients

Ibraheem

Sathar

Seman

et al. 2022

ijhs

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Background: Thalassemia is a genetic blood disorder characterized by insufficient haemoglobin level due to mutation in the globin chains causing anaemia with iron overload and the most common genetic haemoglobinopathy in Malaysia. They are grouped as transfusion dependent and non-dependent according to their transfusion requirement. The frequency of thalassemia transfusions can be discriminated further into monthly to non-monthly transfusion group. Objective: To analyze the socio-demographic characteristic, haemoglobin levels and BMI distribution after classifying the thalassemia patients according to monthly transfused group (MTG), non-monthly transfused group (NMTG) and comparing to a healthy individual control group. Methods and Materials: This was a prospective cross-sectional study gathering data on socio-demographic characteristic, haemoglobin levels and BMI distribution of patients with MTG and NMTG thalassemia patients from a thalassemia clinic in Ampang Hospital and comparing them to healthy individuals in Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. The study embarked between August to October 2020. Results: Our study clearly shows in adult thalassemia MTG are predominantly in Malay ethnicity and younger in comparison to NMTG. The mean Hb levels of MTG is lower compared to NMTG regardless of the genotype and phenotype characteristics.

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Body Mass Index in Thalassemia Children

Cited by 5 publications

References 6 publications

Study of Insulin Hormone Level and β-Cell Function in Children with β-Thalassemia Major

Study of Insulin Hormone Level and β-Cell Function in Children with β-Thalassemia Major

Detection of endocrine disorders in young children with multi-transfused thalassemia major

Malaysian socio-demographic characteristics, mean haemoglobin levels and BMI distribution of the monthly transfused group (MTG) and non-monthly transfused group (NMTG) thalassemia patients

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