Body mass index increase before 3 years‐of‐age augments the degree of insulin resistance corresponding to body mass index in adolescent girls

Arisaka, Osamu; Ichikawa, Go; Sairenchi, Toshimi; Imataka, George; Koyama, Satomi

doi:10.1111/jdi.12700

Cited by 4 publications

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“…In the analysis of our birth cohort, it appeared that girls with an increase in BMI before 3 yr were more prone to develop insulin resistance at 12 yr than boys. Therefore, an increase in adiposity during early growth periods might be of long term relevance for altered insulin sensitivity to adiposity, particularly in girls ( 97 ).…”

Section: Sexual Dimorphismmentioning

confidence: 99%

Childhood obesity: rapid weight gain in early childhood and subsequent cardiometabolic risk

Arisaka

Ichikawa

Koyama

et al. 2020

Clin Pediatr Endocrinol

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. Dynamic changes in body weight have long been recognized as important indicators of risk for human health. Many population-based observational studies have shown that rapid weight gain during infancy, including a catch-up growth phenomenon or adiposity rebound in early childhood, predisposes a person to the development of obesity, type 2 diabetes, and cardiovascular diseases later in life. However, a consensus has not been established regarding which period of weight gain contributes to future risks. This review evaluates recent evidence on the relationship between early rapid growth and future obesity and cardiometabolic risk, with a focus on the differential significance of rapid weight gain in infancy and early childhood. Although there is a need for attention to childhood growth during early infancy before 1 yr of age as it may be related to future obesity, emerging evidence strongly suggests that toddlers showing an increase in body mass index (BMI) before 3 yr of age, a period normally characterized by decreased BMI, are prone to developing later cardiometabolic risk.

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Section: Sexual Dimorphismmentioning

confidence: 99%

Childhood obesity: rapid weight gain in early childhood and subsequent cardiometabolic risk

Arisaka

Ichikawa

Koyama

et al. 2020

Clin Pediatr Endocrinol

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“…We focused on admission blood sampling because it could account for up to 30% of sampling losses occurring in the first month of age. 4 The findings from our study lead to another important scientific question: the impact of limiting phlebotomy losses in the first postnatal month on transfusion needs in extremely premature neonates. Mathematical studies have modelled the extent to which laboratory blood loss could contribute to neonatal anemia, 5 but the effect of limiting phlebotomy losses in extremely premature neonates remains to be studied.…”

Section: Replymentioning

confidence: 80%

“…1,3 We have found that a BMI increase from age 1.5 to 3.0 years, even if BMI is in the normal range just before the increase, is related to a greater increase in Homeostatic Model Assessment of Insulin Resistance per BMI increase at age 12 years compared with a stable or decreased BMI from 1.5 to 3.0 years of age. [4][5][6] These data were obtained from 1.5-and 3.0-year-old checkups, including weight and height measurements, as defined by the Ministry of Health, Labour and Welfare in Japan. This finding suggests that children with a BMI increase before age 3 years, a period normally characterized by decreased BMI, are more prone to developing insulin resistance in adolescence.…”

Section: Early Increase In Body Mass Index and Cardiometabolic Risk Imentioning

confidence: 99%

“…1 This allows us to draw attention to our reported cohort of 38 children with a liver disease of indeterminate etiology, in most cases presenting with acute hepatitis (n = 14) or with PALF (n = 15). 2 This condition was tentatively called "seronegative autoimmune hepatitis" because of the liver histology, the prompt response to immunosuppressive therapy used in typical autoimmune hepatitis 3,4 (prednisone alone or with azathioprine or cyclosporine), and the lack of specific autoantibodies. These features, combined with the lack of evidence of known causes of acute and chronic liver diseases, suggested immune dysregulation and activation.…”

Section: Immunosuppressive Therapy For Indeterminate Acute Hepatitis mentioning

confidence: 99%

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Balasubramanian

Srinivasan

2019

The Journal of Pediatrics

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Although appreciating the findings of the study regarding the use of cord blood sampling in preventing anemia in extremely preterm infants, the authors omitted to emphasize that routine search for coagulation and polymerase chain reaction test abnormalities during the first hours of life is of limited value, providing unreliable results for patient management and potentially unnecessary blood loss. 1-3 We suggest that a possible bias in the difference in transfusion rate between the 2 studies could be due to the relevant amount of blood sampled from venous access in the control group. Assuming that the blood volume in extremely preterm infants is about 80 mL/kg, drawing about 5 mL from each patient would mean a blood loss of about 8% of the circulating volume that could be critical in this delicate setting. Furthermore, although cord blood sampling could be the right direction for preventing anemia in extremely preterm infants, cord blood it is not always available. We suggest that avoidance of sampling for unreliable tests and widespread implementation of point-of-care analyzer with micro-methods technology for blood count, electrolytes, and blood gas could be an adjunctive and even more efficient approach for limiting blood losses in this specific population.

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Section: Immunosuppressive Therapy For Indeterminate Acute Hepatitis mentioning

confidence: 99%

Early increase in body mass index and cardiometabolic risk in adolescence

Arisaka

Ichikawa

Koyama

et al. 2019

The Journal of Pediatrics

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Early increase in body mass index and cardiometabolic risk in adolescence To the Editor: In an assessment of the influence of the weight gain trajectory from birth to 14 years old, Barraclough et al found that an early increase in body mass index (BMI) above the 90th percentile before 3 years of age resulted in an unfavorable cardiometabolic risk profile in adolescence, compared with children with a late increase in BMI. 1 This finding is important because early identification of children with likely future cardiometabolic risks is essential for promoting cardiovascular health in early childhood. 2 We would like to add our view on the relationship between the early BMI pattern and cardiometabolic risk. Early excess BMI before 3 years of age is important in relation to future cardiometabolic risk, but it is not necessary for the child to be overweight or obese at the start of the BMI rise. 1,3 We have found that a BMI increase from age 1.5 to 3.0 years, even if BMI is in the normal range just before the increase, is related to a greater increase in Homeostatic Model Assessment of Insulin Resistance per BMI increase at age 12 years compared with a stable or decreased BMI from 1.5 to 3.0 years of age. 4-6 These data were obtained from 1.5-and 3.0-year-old checkups, including weight and height measurements, as defined by the Ministry of Health, Labour and Welfare in Japan. This finding suggests that children with a BMI increase before age 3 years, a period normally characterized by decreased BMI, are more prone to developing insulin resistance in adolescence. Furthermore, another analysis of longitudinal growth data indicated that BMI rebound (adiposity rebound) earlier than approximately 3 years of age with lower pre-rebound BMI leads to greater risk of childhood obesity. 7 These results suggest that an early increase in BMI before age 3 years is important, even if the absolute BMI is low, because this BMI pattern is closely related to cardiometabolic risk in adolescence.

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Body mass index increase before 3 years‐of‐age augments the degree of insulin resistance corresponding to body mass index in adolescent girls

Cited by 4 publications

References 4 publications

Childhood obesity: rapid weight gain in early childhood and subsequent cardiometabolic risk

Childhood obesity: rapid weight gain in early childhood and subsequent cardiometabolic risk

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Early increase in body mass index and cardiometabolic risk in adolescence

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