Body mass index influences prostate cancer risk at biopsy in <scp>J</scp>apanese men

Masuda, Hitoshi; Kagawa, Makoto; Kawakami, Satoru; Numao, Noboru; Matsuoka, Yoh; Yokoyama, Minato; Yamamoto, Shinya; Yonese, Junji; Fukui, Iwao; Kihara, Kazunori

doi:10.1111/iju.12023

Cited by 16 publications

(25 citation statements)

References 34 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several prospective and retrospective studies have suggested that obese men were more likely to harbor clinically significant prostate cancer and were at higher risk of prostate cancer mortality and recurrence after primary treatment [4][5][6]8,17,[21][22][23][24]. Both overweight and obese men in our cohort were observed to be at significantly increased risk of having clinically significant prostate cancer detected on biopsy, thereby further supporting the growing body of evidence that links obesity to cancer aggressiveness.…”

Section: Discussionsupporting

confidence: 80%

“…In our series, only 6.8% were obese based on the WHO definitions. This value is higher than rates reported in both Korean (1.4%) and Japanese (1.7%) prostate cancer detection study cohorts [17,18]. Comparatively, obesity was markedly more prevalent in other Western studies.…”

Section: Discussioncontrasting

confidence: 61%

“…Park et al [20] recently studied a biopsy population of 1,213 men in Korea and found that men with BMI Z25 kg/m 2 were at 45% increased risk of having prostate cancer detected on biopsy. Masuda et al [17] observed significant elevation in the risk of cancer at biopsy at BMI Z25 kg/m 2 in a Japanese cohort whereas Freedland et al [8] also observed a 98% increased risk in obese men after adjusting for lower PSA levels and larger prostate size in a Western cohort. We believe that the difference in crude and adjusted ORs can be explained by confounding factors such as serum PSA level [10,11], prostate volume [8,9,12], and age, which were anticipated to result in lower prostate cancer detection rates (detection bias) [13] in overweight/obese men.…”

Section: Discussionmentioning

confidence: 96%

“…Unfortunately, the precise reason why cancer detection risk increases at comparatively lower BMI levels (BMI Z25 kg/m 2 ) in Asian men has not been well studied. It has been previously suggested that this could be because Asians have a greater fat percentage at a specific BMI, leading to greater central obesity and its associated peripheral insulin resistance [17,26]. Hyperinsulinemia and raised circulating insulinlike growth factor-1 have also been positively associated with prostate cancer risk [6,7,27,28].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prostate cancer detection: The impact of obesity on Asian men

Lee

Chia

2015

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prostate cancer detection: The impact of obesity on Asian men

Lee

Chia

2015

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

“…1 Body mass index (BMI) might influence the risk of developing other urological cancers, especially renal cell carcinomas (RCC).…”

mentioning

confidence: 99%

Re: Body mass index influences prostate cancer risk at biopsy in Japanese men

Kapoor

2013

Int J of Urology

View full text Add to dashboard Cite

Re: Body mass index influences prostate cancer risk at biopsy in Japanese menThe recent article by Masuda et al. provided highly interesting reading.1 Body mass index (BMI) might influence the risk of developing other urological cancers, especially renal cell carcinomas (RCC).For instance, in one Korean study, individuals with advanced renal cancer and co-existing obesity showed a better clinical outcome in contrast to patients with lower BMI. Individuals with lower BMI tend to show augmented microvascular invasiveness. Similar higher stages are typically associated with RCC in individuals with low BMI. Similarly, higher Fuhrman grades are typically seen with low BMI.2 A similar positive relationship was noted between recurrence-free survival and BMI. A similar association was seen between the Eastern Cooperative Oncology Group (ECOG) performance status and BMI. For instance, RCC individuals with lower BMI tend to show a worse ECOG performance status. Thus, decreased BMI is in fact an independent parameter associated with decreased cancer-free survival. A similar association is seen between recurrence-free survival and BMI. A similar close relationship has been established in clear cell RCC. For instance, in obese patients with clear cell RCC, the cancer-specific survival rate is 81.7%, in contrast to 62.3% in individuals with normal weights. Similarly, in patients with RCC, the preoperative BMI is an independent parameter that significantly influences clinical outcome. In a recent meta-analysis, individuals with higher BMI had better overall survival. 4 A similar association is seen in RCC patients on chemotherapy. RCC patients with an associated BMI of less than 25 are more likely to manifest the toxic effects of chemotherapeutic agents, such as sorafenib.It is obvious from the aforementioned examples that there is a close association between BMI and the risk of developing RCC. Further large-scale studies are required to corroborate these findings. Shailendra Kapoor M.D.Private Practice, Mechanicsville, Virginia, USA shailendrakapoor@yahoo.com Conflict of interestNone declared.

show abstract