Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range

Andersen, Jardar; Herning, H.; Aschim, Elin L.; Hjelmesæth, Jøran; Mala, Tom; Hanevik, Hans Ivar; Bungum, Mona; Haugen, Trine B.; Witczak, Oliwia

doi:10.1371/journal.pone.0130210

Cited by 61 publications

(62 citation statements)

References 48 publications

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“…Besides sperm concentration and count, the relationship between sperm morphology, progressive motility and obesity has been shown in previous studies [14,15]. A study with small sample size depicted that weight loss led to improvement in semen quality including sperm count and normal sperm morphology [15].…”

Section: Discussionmentioning

confidence: 89%

The impact of obesity on semen parameters and hormone levels in infertile men

Özdemir¹,

Tokmak²,

Tuzluoğlu³

et al. 2016

Med-Science

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Previous studies in overweight men have shown an increased likelihood of abnormal semen parameters. Obesity has been found to be associated with male subfertility. In this study we aimed to investigate the effect of obesity on semen parameters and hormone levels in infertile males. This was a prospective crosssectional study designed to assess the influence of obesity on semen parameters and hormone levels in infertile men. 88 obese [Body mass index (BMI) ≥30 kg/m2] men and 169 non-obese (BMI<30 kg/m2) men were eligible for the study. All semen samples were obtained by masturbation after 3 days of sexual abstinence. After liquefaction at room temperature, semen volume, sperm concentration, motility, and normal morphology were determined according to World Health Organization (WHO, 2010) guidelines for semen analysis. Serum hormone levels were measured on the same-day with semen analysis. Semen volume was significantly lower in the obese group than in the non-obese group. No significant differences were observed between the groups in term of other semen parameters. Mean serum total testosterone (TT) level and TT/estradiol (E2) ratio were significantly higher in the non-obese group, whereas mean E2 level was significantly higher in the obese group. There was a significant positive correlation between BMI and E2 levels in the obese group. A significant inverse correlation was observed between BMI and TT levels in the non-obese group. Obesity may reduce semen volume in infertile males. This effect may be due to the changes in sex hormone levels. However, it has no impact on more meaningful indicators of male fertility such as sperm concentration, motility, and morphology.

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Section: Discussionmentioning

confidence: 89%

The impact of obesity on semen parameters and hormone levels in infertile men

Özdemir¹,

Tokmak²,

Tuzluoğlu³

et al. 2016

Med-Science

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“…Из-быток жировой ткани в организме мужчины, вероят-но, приводит к возрастанию числа сперматозоидов с повреждениями в шейке и средней части. Согласно многим исследованиям [1,10,20], у мужчин с НЖО отмечается ухудшение подвижности гамет, что мо-жет быть следствием структурной и/или функцио-нальной патологии митохондрий.…”

Section: патология головкиunclassified

“…Так, у пациентов с варикоцеле и инфекционными заболеваниями урогенитального тракта часто выявляют астенозооспермию (снижение подвижности сперматозоидов), возникающую в ре-зультате множественных структурных нарушений в цитоскелете жгутика. По данным некоторых авторов [1,2,10,11,18], астенозооспермия является частой патологией и у мужчин с ожирением. Возможными причинами могут быть гипертермия и оксидативный стресс, возникающие в результате увеличения про-слойки жировой ткани в мошонке.…”

Section: патология головкиunclassified

“…Однако отме-чена отрицательная корреляция показателя концен-трации сперматозоидов с увеличением ИМТ: у паци-ентов с ожирением количество гамет в 1 мл эякулята было статистически достоверно меньше, чем у лиц с нормальным ИМТ (53,1±42,5 и 62,3±42,6 млн соот-ветственно; р<0,05). Полученные нами данные со-гласуются с результатами ранее проведенных иссле-дований [1,10].…”

Section: результатыunclassified

“…Andersen и соавт. [1] в исследовании с участи-ем 166 мужчин, 45 из которых имели нормальный ИМТ, 52 -избыточную массу тела, у 31 диагности-ровали ожирение I степени (ИМТ= 30,0-34,9 кг/ м 2 ), у 38 -ожирение II степени и морбидное ожире-ние (ИМТ≥35,0 и ИМТ≥40,0 кг/м 2 соответственно), выявили статистически значимую отрицательную зависимость между повышенным ИМТ, концентра-цией и общим количеством сперматозоидов в эяку-ляте, процентом живых сперматозоидов, подвижно-стью и числом морфологически нормальных гамет. S. Belloc и соавт.…”

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See 2 more Smart Citations

Changing of the ejaculate parameters and sperm structure in men with overweight

Vityazeva¹,

Алташина²,

Razina³

et al. 2016

Probl. reprod.

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The association between serum estradiol levels and sperm DNA integrity

Svensjö

Axelsson

2022

Environ and Mol Mutagen

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In men from the general population, BMI has been associated with a lower sperm DNA fragmentation index (DFI). We wondered whether this could be due to estradiol, which is associated with BMI and reported important for sperm function. Our objective was to investigate the association between estradiol and DFI. In 2008-2010, we recruited 284 young men from the general population to deliver samples of semen and blood and answer questionnaires. Serum concentrations of reproductive hormones and DFI were analyzed, the latter using the Sperm Chromatin Structure Assay. Associations were studied using general linear models. The first model utilized metric values of estradiol, whereas the second model compared men with high and low levels, dichotomized by the median value. A possible interaction between estradiol and testosterone was also examined. When investigating metric estradiol levels and DFI, an inverse association was seen without adjustments (p = .02), but the statistical significance was lost at adjustments for potential confounders (p = .08). Men with lower estradiol levels (<88 pmol/L, mean 71 pmol/L) had a statistically significantly higher DFI than men with higher levels of estradiol (≥88 pmol/L, mean 110 pmol/L). Mean ratio difference was 1.21 (p = .002) without adjustments and 1.18 (p = .01) with adjustments. A statistically significant difference in DFI was observed in men with testosterone levels below median when comparing high and low estradiol (p < .001). This study supports the idea that serum estradiol levels are protective for sperm DNA integrity, at least at lower testosterone levels.

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Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range

Cited by 61 publications

References 48 publications

The impact of obesity on semen parameters and hormone levels in infertile men

The impact of obesity on semen parameters and hormone levels in infertile men

Changing of the ejaculate parameters and sperm structure in men with overweight

The association between serum estradiol levels and sperm DNA integrity

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