Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents

Siervo, Mario; Sorice, Rossella; Nutile, Teresa; Aversano, Mario; Iafusco, M.; Vetrano, Francesco; Wells, Jonathan C. K.; Stephan, Blossom C M; Ciullo, Marina

doi:10.1016/j.nut.2011.06.007

Cited by 66 publications

(49 citation statements)

References 27 publications

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“…Other authors 3,22 also found that low HDL values, regardless of nutritional status, questioned whether the cutoff would be ideal for this population or such outcomes would already be indicative of a serious public health problem.…”

Section: Discussionmentioning

confidence: 98%

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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Section: Discussionmentioning

confidence: 98%

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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“…The direct correlation observed between HMGB1 and BMI is evidence of the link between obesity and inflammation. Several studies have highlighted the strong relationship between obesity, BMI, and inflammation (26,27). Garanty-Bogacka et al (28) revealed that, after a program of physical activity and low-calorie diet, there was a reduction in the levels of inflammatory cytokines associated with a consequential improvement in obesity markers, such as BMI.…”

Section: Discussionmentioning

confidence: 99%

High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children

Arrigo

Chirico

Salpietro

et al. 2013

European Journal of Endocrinology

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Introduction: Obesity is associated with a chronic low-grade inflammation. High-mobility group box 1 protein (HMGB1) plays a key role in inflammation and immunostimulatory and chemotactic processes. The aim of the study was to assess the role of HMGB1 in obese children and to evaluate its diagnostic profile in identifying childhood obesity-related complications, such as the metabolic syndrome (MS). Patients and methods: Sixty obese children were enrolled and compared with 40 healthy children (control). Homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, thyroid hormones, and pro-and anti-inflammatory peptides such as C-reactive protein (CRP), adiponectin, interleukin 6 (IL6), IL18, IL23, TNFa, resistin, and HMGB1 were evaluated. Receiver operating characteristics (ROC) analysis was employed to calculate the area under the curve (AUC) for HMGB1, IL6, and adiponectin to find the best cutoff values capable of identifying MS in obese children. Results: HMGB1 levels were statistically higher in obese patients than in the control group (19.4G6.8 vs 3.7G1.2 ng/ml; P!0.0001). In obese patients, IL18, IL6, and resistin levels were significantly high, while adiponectin levels were low. At multivariate analysis, HMGB1 was found to be independently correlated with BMI, IL23, IL6, free triiodothyronine, HDL, and HOMA-IR. At ROC analysis, HMGB1 showed higher sensitivity and specificity (AUC, 0. 992; sensitivity, 94.7%; specificity, 97.5%) than IL6 and adiponectin in identifying MS in obese children. Conclusion: HMGB1 plays an important role in the inflammatory process associated with childhood obesity. This peptide may be an important diagnostic marker for obesity-related complications, such as MS.

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“…Plasma VEGF levels were significantly associated with features of the metabolic syndrome (MetS) such as BMI, waist circumference, blood pressure and inflammation [5,6].…”

Section: Introductionmentioning

confidence: 99%

VEGF is indirectly associated with NO production and acutely increases in response to hyperglycaemia¹

Siervo

Tomatis

Stephan

et al. 2012

Eur J Clin Investigation

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Eur J Clin Invest 2012; 42 (9): 967–973 Abstract Background Increased levels of vascular endothelial growth factor (VEGF) have been observed in patients with metabolic syndrome (MetS). Nitric oxide (NO) formation is reduced in MetS, but its relationship to VEGF production remains poorly defined. We evaluated the association between VEGF/NO synthesis and insulin sensitivity in obese subjects and investigated the secretory response of VEGF to an acute elevation of glucose. Materials and methods Seven healthy normal‐weight subjects, seven obese subjects without MetS and seven obese subjects with MetS were recruited. Anthropometry, body composition and cardiometabolic functions (blood pressure, glucose, insulin, triglycerides, total cholesterol, HDL‐C and VEGF) were measured, and a novel stable isotope method was used to assess in vivo rates of NO production. A frequent sampling intravenous glucose tolerance test was performed to study the dynamics of VEGF release. Results Fasting VEGF levels were significantly higher in the two obese groups compared to the control group (P for trend = 0·02), but the difference was not significant after adjustment for age. Vascular endothelial growth factor levels were associated with systolic blood pressure (ρ = 0·54; P = 0·01) and NO production (ρ = −0·44; P = 0·04). Vascular endothelial growth factor levels increased in response to acute hyperglycaemia in normal‐weight and obese subjects (P < 0·001). Conclusions Vascular endothelial growth factor levels rapidly increase during hyperglycaemia and are inversely related to NO production at steady state. The potential link between the acute secretion of VEGF and atherosclerotic risk in subjects with poorly controlled glycaemia as well as the potential of lowering elevated VEGF levels by increasing NO production and/or availability warrants further investigation.

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Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents

Cited by 66 publications

References 27 publications

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children

VEGF is indirectly associated with NO production and acutely increases in response to hyperglycaemia¹

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Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents

Cited by 66 publications

References 27 publications

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children

VEGF is indirectly associated with NO production and acutely increases in response to hyperglycaemia1

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VEGF is indirectly associated with NO production and acutely increases in response to hyperglycaemia¹