Body Mass Index-Modified Relationship of Chronic Mental Stress With Resting Blood Pressure During 5 Years in Japanese Middle-Aged Male Workers

Toyoshima, Hideaki; Otsuka, Rei; Hashimoto, Shuji; Koji, Takehiko; Yatsuya, Hiroshi

doi:10.1253/circj.cj-13-1086

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…These GO terms were mainly related to blood pressure. A previous study showed that acute MI Patients with lower mean blood pressure (<79 mmHg) presented a significantly higher risk of in-hospital mortality (15), while the average systolic and diastolic blood pressure was significantly related to obesity (16). Our results were consistent with these previous findings and partially explained the lower modality rates of acute MI patients with obesity (6, 7).…”

Section: Functional Enrichment Analysissupporting

confidence: 91%

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Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Zhao

Cao

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Obesity has been shown as a risk factor to increase the incidence of myocardial infarction (MI). However, obesity has also been linked to the decreased mortality of acute MI with unknown mechanisms. Here, we firstly used large-scale literature data mining to identify obesity downstream targets and MI upstream regulators with polarity, based on which an obesity-MI regulatory network was constructed. Then, a gene set enrichment analysis was conducted to explore the functional profile of the genes involved in the obesity-MI regulatory networks. After that, a mega-analysis using MI RNA expression datasets was conducted to test the expression of obesity-specific genes in MI patients, followed by a shortest-path analysis to explore any potential gene-MI association. Our results suggested that obesity could inhibit 11 MI promoters, including NPPB, NPPA, IRS1, SMAD3, MIR155, ADRB1, AVP, MAPK14, MC3R, ROCK1, and COL3A1, which were mainly involved in blood pressure-related pathways. Our study suggested that obesity could influence MI progression by driving multiple genes associated with blood pressure regulation. Moreover, PTH could be a novel obesity driven gene associated with the pathogenesis of MI, which needs further validation.

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Section: Functional Enrichment Analysissupporting

confidence: 91%

“…Their results showed that patients with lower admission MAP (<79 mmHg) presented worse inhospital prognosis (15). Interestingly, obesity (BMI ≥ 25 kg/m 2 ) was significantly related to higher average SBP, DBP, and MAP (16,25,26). These observations indicated an inhibitive role of obesity in the progression of MI.…”

Section: Discussionmentioning

confidence: 97%

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Zhao

Cao

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Changes in cardiovascular disease risk and behavioural risk factors before the introduction of a health check programme in England

Alageel

Wright

Gulliford

2016

Preventive Medicine

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A population-based programme of health checks was introduced for adults in England in 2011 for the primary prevention of cardiovascular diseases (CVD) and risk factors management. The aim was to evaluate changes in cardiovascular risk and behavioural risk factors in a health check eligible population in England from 1994 to 2013, by using repeated cross-sectional design using seven surveys of the Health Survey for England. Measures included traditional CVD risk factors and behavioural risk factors. Linear trends were estimated allowing for sampling design. The surveys comprised 49,805 adults aged 45 to 74years; 30,639 were free from cardiovascular comorbidity; 16,041 (52%) had complete data for quantitative risk factors. Between 1994 and 2013, systolic blood pressure decreased by 3.1 (95% confidence interval 2.5 to 3.6) mmHg per decade in men and 5.0 (4.5 to 5.5) in women. Total cholesterol decreased by 0.20 (0.16 to 0.24) mmol/l per decade in men; 0.23 (0.19 to 0.26) in women. Smoking declined by 6% (5% to 8%) per decade in men; 7% (6% - 8%) in women. The proportion with CVD-risk ≥20% declined by 6.8% per decade in men; 2.4% in women. Multiple behavioural risk factors were strongly associated with estimated CVD-risk, but improving trends in traditional CVD risk factors were inconsistent with increasing indicators of adiposity. Long-term declines in traditional risk factors contributed to reductions in estimated CVD-risk prior to the introduction of a health check programme. Behaviour change interventions for multiple risk factor exposures remain a key area for future research.

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Body Mass Index-Modified Relationship of Chronic Mental Stress With Resting Blood Pressure During 5 Years in Japanese Middle-Aged Male Workers

Cited by 2 publications

References 41 publications

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Changes in cardiovascular disease risk and behavioural risk factors before the introduction of a health check programme in England

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