Body mass index modifies the association between frequency of alcohol consumption and incidence of hypertension in men but not in women: a retrospective cohort study

Nishigaki, Daiki; Yamamoto, Ryohei; Shinzawa, Maki; Kimura, Yoshiki; Fujii, Yasuhisa; Aoki, Katsunori; Tomi, Ryohei; Ozaki, Sho; Yoshimura, Ryuichi; Taneike, Manabu; Nakanishi, Kaori; Nishida, Makoto; Yamauchi–Takihara, Keiko; Isaka, Yoshitaka; Moriyama, Toshiki

doi:10.1038/s41440-019-0382-8

Cited by 9 publications

(14 citation statements)

References 34 publications

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“…Previous epidemiological studies have reported that heavy alcohol consumption was associated with a higher incidence of HT and DM, which are known risk factors for CKD, but the alcohol-induced risk was reduced in those with higher BMI. [14][15][16][17][18][19][20] However, minimal evidence is available on the association between alcohol consumption and the risk of CKD considering the effect of factors such as body mass on alcohol tolerance.…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16][17] Recent studies in Japan have shown that a higher body mass index (BMI) attenuates the risk of developing HT and DM due to alcohol consumption. [18][19][20] However, no previous studies have examined this association with regard to CKD development. Therefore, we hypothesized that a high BMI would have a protective effect against CKD development and a lower BMI would enhance the harmful effects of alcohol consumption on CKD development.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Body Mass Index on the Association Between Alcohol Consumption and the Development of Chronic Kidney Disease

Hashimoto

Kato

Yasuda

et al. 2021

Preprint

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Although previous studies demonstrated that alcohol consumption is associated with low chronic kidney disease (CKD) risk, they did not consider individual body mass and metabolic capacity. We examined whether the body mass index (BMI) affects the association between drinking and CKD. We defined CKD as an estimated glomerular filtration rate decline < 60 mL/min/1.73 m2 and/or dipstick proteinuria (≥ 1+). Participants were 11,175 Japanese individuals aged 40–74 years without baseline CKD who underwent annual health checkups. Daily alcohol consumption was estimated from a questionnaire, and the participants were categorized as "infrequent drinkers," "light drinkers (< 20 g/day)," "moderate drinkers (20–40 g/day)," and "heavy drinkers (≥ 40 g/day)." Over a median 5-year observation period, 936 participants developed CKD. Cox proportional hazards models revealed that light drinkers had a significantly reduced risk of CKD compared with infrequent drinkers (P = 0.01). Stratified by BMI, the low BMI (< 18.5 kg/m2) group had an increased risk of CKD even in light drinkers, while the high BMI (≥ 25.0 kg/m2) group had a decreased risk of CKD regardless of alcohol consumption. Taken together, alcohol consumption did not reduce the CKD risk in all populations; individual tolerance must be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Body Mass Index on the Association Between Alcohol Consumption and the Development of Chronic Kidney Disease

Hashimoto

Kato

Yasuda

et al. 2021

Preprint

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“…The results of our study were consistent with those of previous epidemiological studies. 4,[17][18][19][20][21][22][23][24] We also analyzed the combined effect of alcohol consumption and SDB on hypertension. The results showed that participants with high RDI who were alcohol drinkers had higher ORs than those with either factor alone, even after adjustment for potential confounding factors.…”

Section: Discussionmentioning

confidence: 99%

“…30 Obesity and alcohol intake are known important risk factors for SDB, 10,31 and these factors are independently associated with hypertension. [17][18][19][20][21][22][23][24] Thus, bus drivers may be at a higher risk of hypertension, and the combination of these risk factors may impose a higher risk of hypertension than each factor alone. These results emphasize the need for comprehensive approaches and measures, such as the Swiss cheese model, which is a model for mitigating the risk with different types of defense layers, to control hypertension among bus drivers.…”

Section: Discussionmentioning

confidence: 99%

“…14 These findings suggest that early detection and treatment of SDB is important in the overall management of hypertension. 15 On the other hand, alcohol consumption is also known to be a major risk factor for hypertension [16][17][18][19][20] and is also related to severe hypoxemia and severe SDB. [21][22][23][24] Although both SDB and alcohol consumption are associated with hypertension, the combined effects of alcohol consumption and SDB on hypertension remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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Association of sleep-disordered breathing and alcohol consumption with hypertension among Japanese male bus drivers

et al. 2021

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There is limited evidence regarding the combined effects of sleep-disordered breathing (SDB) and alcohol consumption on hypertension. The aim of this study was to examine the combined effects of SDB and alcohol consumption on hypertension in Japanese male bus drivers. This cross-sectional study included 2 525 Japanese male bus drivers aged 20 to 65 years. SDB was assessed using a single-channel airflow monitor, which measured the respiratory disturbance index (RDI) during overnight sleep at home. Alcohol consumption (g/day) was assessed by a self-administered questionnaire and calculated per unit of body weight. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg and/or use of antihypertensive medications. Multiple logistic regression analyses were performed to examine the association of the combined categories of RDI and alcohol consumption with hypertension. The multivariable-adjusted odds ratio (OR) and 95% confidence interval (95% CI) of hypertension for the alcohol consumption ≥1.0 g/day/kg and RDI ≥20 events/h group were 2.41 (1.45-4.00) compared with the alcohol consumption <1.0 g/day/kg and RDI <10 events/h group. Our results suggest that Japanese male bus drivers with both SDB and excessive alcohol consumption are at higher risk of hypertension than those without SDB and excessive alcohol consumption, highlighting the importance of simultaneous management of SDB and excessive alcohol consumption to prevent the development of hypertension among bus drivers.

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Annual reports on hypertension research 2020

et al. 2021

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Body mass index modifies the association between frequency of alcohol consumption and incidence of hypertension in men but not in women: a retrospective cohort study

Cited by 9 publications

References 34 publications

Effect of Body Mass Index on the Association Between Alcohol Consumption and the Development of Chronic Kidney Disease

Effect of Body Mass Index on the Association Between Alcohol Consumption and the Development of Chronic Kidney Disease

Association of sleep-disordered breathing and alcohol consumption with hypertension among Japanese male bus drivers

Annual reports on hypertension research 2020

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