Background: Proper sexual function is an important factor that affects family strength. Recently, the issue of obesity and the influence of body mass index (BMI) on sexual function have received increasing research attention. Objectives: This study aimed to investigate the relationship between sexual function and its domains with obesity and central obesity. Methods: This cross-sectional study was conducted on 514 women aged 15 -45 years who presented at Shiraz healthcare centers in 2014 -2015. Simple random sampling was performed. Data were collected by applying the female sexual function index (FSFI), weight, and meter. The questionnaire consisted of 19 questions that evaluated six domains, as follows: sexual desire, arousal, lubrication, orgasm, satisfaction, and pain. Scores < 28 on the questionnaire were considered to represent sexual dysfunction. The results were analyzed using the t-test, Fisher test, Chi-square test, and Pearson correlation coefficient.