Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine—a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium

Abstract

Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.

Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis

“…As shown in Figure 1, screening of the 2,319 papers identified in our search strategy resulted in nine publications [21][22][23][24][25][26][27][28][29] deemed eligible for inclusion in the review. The characteristics of these are summarised in Table 1 and consist of four studies from prospective cohorts or consortiums [21,23,24,28], two population-based case-control studies [25,29] and three hospital-based case-control studies [22,26,27].…”

“…The characteristics of these are summarised in Table 1 and consist of four studies from prospective cohorts or consortiums [21,23,24,28], two population-based case-control studies [25,29] and three hospital-based case-control studies [22,26,27]. These studies, of variable quality, originated from America, Europe and a large Asian cohort consortium (Table 1).…”

“…One cohort consortium [21] also reported observing non-significant direct associations between smoking and overall small intestine cancer risk, which remained in analysis of SIA only. However, this study did not present RR and 95% CI for SIA risk and therefore could not be incorporated in our meta-analysis.…”

Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people

“…3 Nonetheless, prospective evidence on the relevance of adiposity for SIC risk has been inconclusive. 4 The present study examined the associations of general and central adiposity with risks of CRC and SIC within the China Kadoorie Biobank (CKB) population of 0.5 million adults, both overall and by sex and anatomical site.…”

Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles

“…2 The estimated number of new individuals diagnosed with colorectal tumor, including both men and women, will reach 136,830 in the US in 2014, and 50,310 patients will be killed by this carcinoma, 2,3 in part because of the risk factors, which include diet, obesity, sedentariness, lack of physical activity, smoking, alcohol intake, and so forth. [4][5][6][7][8] Although the pathogenesis and diagnostic techniques of colon tumor has been best understood, [9][10][11] a considerable percentage of this cancer is advanced carcinoma, typically metastasized and difficult to fully eradicate through surgery, when they are found. Consequently, plenty of chemotherapeutic agents are employed in the therapy of a variety of terminal cancers.…”