Body Retention of Carbon 14 from Labeled Sodium Bicarbonate

Skipper, Howard E.; White, Locke; Bryan, Carl E.

doi:10.1126/science.110.2856.306

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Actually, this picture of slow terminal elimination of radioactivity by mice was reported =25 yr ago by Skipper (Skipper et al, 1949a(Skipper et al, , 1949bSkipper, 1952) while estimating the danger of internal radiation from ingested radiochemicals. Carbon-14-labeled sodium bicarbonate and formate were his test substances.…”

Section: Thiabendazole (Tbz)mentioning

confidence: 79%

Non‐drug‐related residues in tracer studies

Rosenblum

1977

Journal of Toxicology and Environmental Health

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Factors involved in residue studies with radioactive tracers are discussed. Three types of metabolic management of 14 C-labeled compounds are described. Intact incorporation into protein of chick muscle is demonstrated with L-O-ethyl-[ 14 C/threonine. Retention of unchanged and quantitatively recoverable parent compound occurred with [ 14 C] thiabendazole sprayed on oranges. The latter drug fed to animals was retained in tissue partly intact, but mostly metabolized to recognizable detoxification products, and ultimately to endogenous tissue components. The latter type of residue was termed a "nonmetabolite" residue. The extreme case of extensive metabolism to products structurally unrelated to the parent compound was illustrated with [ 14 C] ronidazole administered to turkeys.

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Section: Thiabendazole (Tbz)mentioning

confidence: 79%

Non‐drug‐related residues in tracer studies

Rosenblum

1977

Journal of Toxicology and Environmental Health

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“…the behavior of NaH14CQ3 when administered to animals, and is presumably also true of the avian species (Skipper et al, 1949a(Skipper et al, ,b, 1952.…”

Section: Elimination Of Radioactivity Expiration Of Radioactivementioning

confidence: 99%

Metabolism of ronidazole (1-methyl-5-nitroimidazol-2-ylmethyl carbamate)

Rosenblum¹,

Trenner²,

Buhs³

et al. 1972

J. Agric. Food Chem.

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Ronidazole-14C was administered to turkeys in diets containing 0.003-0.008% of drug. More than 80 % of administered radioactivity was excreted and 1-2% was exhaled as 14C02. Metabolites were 2hydroxymethyl-l-methyl-5-nitroimidazole in trace amounts. Also found were A-methylglycolamide, methylamine, and oxalic acid. Radioactivity in tissues was associated with a number of normal body metabolites, such as glutamic and aspartic acids and citric acid cycle intermediates. The presence of acetyl-14C was demonstrated in urine and liver tissue. Radioactive protein, nucleic acid, and lipid fractions were found in whole liver, leading to the conclusion that extensive biodegradation of ronidazole-14C allows the recombination of carbon-14 into body metabolites.

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The non‐metabolite residue a limitation to the tracer method

Rosenblum

Trenner

Wolf

1971

J. Labelled Cpd. Radiopharm.

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SUMMARYThe occurrence of non-metabolite residues from labeled drugs administered to animals is discussed. Selected are 14C-labeled thiabendazole, nitroglycerine, nortriptyline, amitryptiline, p-dimethylaminobenzene, nihydrazone and ronidazole. The rapid degradation which is responsible for the phenomenon requires that all tracer applications in living systems be accompanied by a demonstration of ihe biological stability of the parent con+pound,

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Body Retention of Carbon 14 from Labeled Sodium Bicarbonate

Cited by 7 publications

References 5 publications

Non‐drug‐related residues in tracer studies

Non‐drug‐related residues in tracer studies

Metabolism of ronidazole (1-methyl-5-nitroimidazol-2-ylmethyl carbamate)

The non‐metabolite residue a limitation to the tracer method

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