Body size and physical exercise, and the risk of multiple sclerosis

Cortese, Marianna; Riise, Trond; Bjørnevik, Kjetil; Myhr, Kjell–Morten

doi:10.1177/1352458517699289

Cited by 35 publications

(27 citation statements)

References 283 publications

(433 reference statements)

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“…Exercise training (ET) attenuates symptoms and delays the progression of disability in multiple sclerosis (MS) patients, while low levels of physical fitness have been suggested as a risk factor for developing MS . Accordingly, ET has been shown to modulate other autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, and others .…”

Section: Introductionmentioning

confidence: 99%

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Fainstein

Tyk

Touloumi

et al. 2019

Ann Clin Transl Neurol

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Background Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity‐dependent effects of ET on the systemic immune system in EAE remain undefined. Objective (1) To compare the systemic immune modulatory effects of moderate versus high‐intensity ET protocols in protecting against development of EAE; (2) To investigate whether ET affects autoimmunity selectively, or causes general immunosuppression. Methods Healthy mice performed moderate or high‐intensity treadmill running programs. Proteolipid protein (PLP)‐induced transfer EAE was utilized to examine ET effects specifically on the systemic immune system. Lymph node (LN)‐T cells from trained versus sedentary donor mice were transferred to naïve recipients and EAE severity was assessed, by clinical assessment and histopathological analysis. LN‐T cells derived from donor trained versus sedentary PLP‐immunized mice were analyzed in vitro for proliferation assays by flow cytometry analysis and cytokine and chemokine receptor gene expression using real‐time PCR. T cell‐dependent immune responses of trained versus sedentary mice to the nonautoantigen ovalbumin and susceptibility to Escherichia coli‐induced acute peritonitis were examined. Results High‐intensity training in healthy donor mice induced significantly greater inhibition than moderate‐intensity training on proliferation and generation of encephalitogenic T cells in response to PLP‐immunization, and on EAE severity upon their transfer into recipient mice. High‐intensity training also inhibited LN‐T cell proliferation in response to ovalbumin immunization. E. coli bacterial counts and dissemination were not affected by training. Interpretation High‐intensity training induces superior effects in preventing autoimmunity in EAE, but does not alter immune responses to E. coli infection.

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Section: Introductionmentioning

confidence: 99%

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Fainstein

Tyk

Touloumi

et al. 2019

Ann Clin Transl Neurol

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“…(34) Generally, according to the current research, it can clearly be concluded that exercise can be the basis of treating patients with MS. It has been shown that any of the mentioned exercises can have a positive effect on all types of symptoms commonly seen in patients with MS. (35) Exercise leads to a significant improvement in life quality without any negative impact, because all studies that track adverse results didn't show an increase in the exacerbation of the disease or events. Note that it doesn't seem that exercise prevent or reduce the frequency of recurrence of the disease, but it improves endurance and coordination of the patient.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise on the Therapeutic and Rehabilitation Process of Patients with Multiple Sclerosis- A Narrative Review

Saadat¹,

Hojjati²,

Naghshineh³

et al. 2019

jemds

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BACKGROUND Multiple sclerosis (MS) is a chronic, autoimmune and inflammatory nervous system disease. It leads to the loss of myelin in the white matter of brain, spinal cord and optic nerves, and causes tiredness, muscle cramp, tremor, unsteady gait and some inability to move. Due to the effects of exercise in patients with MS, we aimed to evaluate the effect of exercise on the therapeutic and recovery process of patients with MS. In this study, a narrative review was conducted using keywords, including Multiple Sclerosis, exercise, recovery, treatment, through searching in international scientific databases, such as PubMed, Web of Science and Scopus, on articles published form inception. Different types of exercises were assessed and reported by the researchers as beneficial rehabilitation strategies for patients to manage symptoms restore function, optimize quality of life, promote wellness and back to activities of daily living. These exercises include endurance exercises (aerobics), balance exercises, flexibility exercises, yoga exercises, hypnosis exercises, physiotherapy exercises and exercise in water. Because of positive effects of sport exercises, it is recommended that training program be considered as a complementary treatment alongside other treatments for MS patients.

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“…Selected controls were frequency-matched on year of birth from the Norwegian Conscript Service database (n=19,530). 7 The study found that men who developed relapsing MS symptoms up to 2 years following their cognitive assessment had significantly lower cognition scores compared with controls as did men who developed PPMS up to 20 years after their assessment, suggesting that cognitive problems may be present before apparent symptoms of MS. A second nested case-control study using the same Norwegian population-based database and MS registry found that a body mass index ≥25 was significantly associated with an increased risk of MS in men and that exercise may be a modifiable protective factor for MS. 8 The prodromal period for MS requires additional study to better characterize it and to recognize the progression to clinical MS.…”

Section: Clinical Course Of Multiple Sclerosismentioning

confidence: 99%

Risk-Benefit Analysis and Personalized Treatment in Multiple Sclerosis

2018

International Journal of MS Care

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Nurses-The CMSC designates this activity for 1.0 credit of continuing nursing education (1.0 credits are in the area of pharmacology). For information about the nursing accreditation of this program, please contact the CMSC at education@mscare.org. INSTRUCTIONS FOR OBTAINING CREDIT To receive credit, learners must complete online posttest and evaluation located at www.rockpointe.com/MSsupplement. FEE INFORMATION There is no fee for this educational activity. DISCLOSURE STATEMENT The Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Commercial Support, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of a continuing medical education program provided by PCME are required to disclose any relevant financial relationships with any commercial interest to PCME as well as to learners. All conflicts of interest are identified and resolved by PCME in accordance with the Standards for Commercial Support in advance of delivery of the activity to learners. Disclosures will be made known to the participants prior to the activity.

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Body size and physical exercise, and the risk of multiple sclerosis

Abstract: These findings add weight to evidence linking being overweight to an increased MS risk in men. Furthermore, they suggest that exercise may be an additional modifiable protective factor for MS.

Cited by 35 publications

References 283 publications

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Exercise intensity‐dependent immunomodulatory effects on encephalomyelitis

Effects of Exercise on the Therapeutic and Rehabilitation Process of Patients with Multiple Sclerosis- A Narrative Review

Risk-Benefit Analysis and Personalized Treatment in Multiple Sclerosis

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