Body size and the risk of colon cancer in a large case-control study

Caan, Bette J.; Coates, AO; Ml, Slattery; Potter, J. D.; Quesenberry, C.P.; Edwards, Steven M.

doi:10.1038/sj.ijo.0800561

Cited by 142 publications

(111 citation statements)

References 17 publications

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“…Our study, as well as others (Garfinkel, 1985;Wu et al, 1987;Russo et al, 1998;Robsahm and Tretli, 1999;Murphy et al, 2000), shows a positive association between the risk of colon cancer of BMI in men but not in women. Other case -control studies Caan et al, 1998) and a cohort study (Ford, 1999) have shown a significant positive association between the risk of colon cancer and BMI in both sexes, although this was weaker among women in the two case -control studies. Central obesity, which may increase colon cancer risk by acting as a tumour-growth promoter or mitogen (Giovannucci, 1995;Bjorntorp, 1991), is more common among males.…”

Section: Discussionmentioning

confidence: 76%

Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study

et al. 2003

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Colorectal cancer incidence in relation to body size, smoking, and alcohol consumption was studied in a cohort of 29 051 city residents of Japan. In 1992, each participant completed a self-administered questionnaire on sociodemographic characteristics, drinking, cigarette smoking, diet, exercise, and reproductive and medical histories. The response rate was 92%. From 1993 to 2000, 161 men and 134 women were diagnosed with colorectal cancer at two major hospitals in the city. Relative risks and 95% confidence intervals were calculated by using Cox proportional hazard models. A positive relation between height and colorectal cancer was seen in both sexes, controlling for age, body mass index (BMI), smoking and drinking habits, and years of education. The findings were statistically significant only for men (relative risk 2.13 for the tallest compared with the shortest height tertile; 95% confidence interval ¼ 1.26 -3.58). Body mass index was also associated positively with colon cancer risk for men, whereas the pattern for women was not clear. There was a positive association between pack-years of cigarette smoking and the risk of rectal cancer in men. A positive dose -response relation between alcohol consumption and colon cancer risk was observed for men and women.

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Section: Discussionmentioning

confidence: 76%

Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study

et al. 2003

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“…Although the precise causes of colon cancer remain unclear, various dietary components such as high consumption of red meat or animal fat, physical inactivity, and obesity have been studied as possible risk factors. Despite the number of prospective [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] and case-control [19][20][21][22][23][24][25][26][27] studies that have examined the association between body size and colon cancer in greater or lesser detail, the evidence of obesity as a risk factor is inconclusive. Several studies [4][5][6][7][8][9][10][11][12][13]19,[22][23][24] have found positive associations between body mass and risk of colon cancer in men, whereas most of the studies [4][5][6][7]9,[14][15][16][20]…”

Section: Introductionmentioning

confidence: 99%

A prospective study of body size and colon cancer mortality in Japan: The JACC Study

et al. 2004

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OBJECTIVE:To determine whether body size measurements are risk factors for colon cancer death among the Japanese. DESIGN AND SUBJECTS: A nationwide prospective study, the Japan Collaborative Cohort (JACC) Study from 1988 to 1999. The present analysis included 43 171 men and 58 775 women aged 40-79 y who respond to a questionnaire on current weight and height, weight around 20 y of age, and other lifestyle factors. Body mass index (BMI) at baseline and 20 y of age (B-BMI and 20-BMI, respectively) were calculated. RESULTS: We identified 127 deaths from colon cancer during the follow-up of 424 698 person-years among men and 122 deaths during the follow-up of 591 787 person-years among women. After adjustments for the lifestyle factors known to modify the risk of colon cancer, weight at baseline showed a significant positive association in women, while no such association was seen in men. There was also a significant trend of increasing risk with the increase in B-BMI among women. Women with B-BMI Z28 kg/m 2 had a relative risk (RR) of 3.41 (95% confidence interval (CI): 1.44-8.06) compared with those with BMI of 20-o22 kg/m 2 . 20-BMI also presented the same trend of increasing risk as B-BMI. Women with 20-BMI of o22 and B-BMI of 426 kg/m 2 , that is, excessive BMI gain, had a high RR of 3.41 (95% CI 1.29-9.02) compared with those with 20-BMI of o22 and B-BMI of o22 kg/m 2 . There were no corresponding trends of colon cancer risk for B-BMI, 20-BMI, or BMI change among men. CONCLUSIONS: These study data suggest that obesity and excessive weight gain are associated with the risk of colon cancer death in Japanese women but no such relationship was found in Japanese men.

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“…There is considerable evidence for associations between obesity and increased risk of postmenopausal breast cancer 10 -12,15 , colon cancer 7,8,13,15 , endometrial cancer 9,15 and renal cell cancer 15,16 . Obesity is possibly also associated with increased risk of prostate cancer 5,6,15 , adenocarcinoma of the oesophagus 15,17 and thyroid cancer 15 .…”

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confidence: 99%

Overweight, obesity and fat distribution in 50- to 64-year-old participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Haftenberger

Lahmann

Panico

et al. 2002

Public Health Nutr.

256

232

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Objective: To describe anthropometric characteristics of participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis includes study populations from 25 centres in nine European countries. The British populations comprised both a population-based and a 'healthconscious' group. The analysis was restricted to 83 178 men and 163 851 women aged 50 -64 years, this group being represented in all centres. Methods: Anthropometric examinations were undertaken by trained observers using standardised methods and included measurements of weight, height, and waist and hip circumferences. In the 'health-conscious' group (UK), anthropometric measures were predicted from self-reports. Results: Except in the 'health-conscious' group (UK) and in the French centres, mean body mass index (BMI) exceeded 25.0 kg m 22 . The prevalence of obesity (BMI $ 30 kg m 22 ) varied from 8% to 40% in men, and from 5% to 53% in women, with high prevalences (. 25%) in the centres from Spain, Greece, Ragusa and Naples (Italy) and the lowest prevalences (,10%) in the French centres and the 'healthconscious' group (UK). The prevalence of a large waist circumference or a high waistto-hip ratio was high in centres from Spain, Greece, Ragusa and Naples (Italy) and among women from centres in Germany and Bilthoven (The Netherlands). Conclusions: Anthropometric measures varied considerably within the EPIC population. These data provide a strong base for further investigation of anthropometric measures in relation to the risk of chronic diseases, especially cancer.

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Body size and the risk of colon cancer in a large case-control study

Cited by 142 publications

References 17 publications

Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study

Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study

A prospective study of body size and colon cancer mortality in Japan: The JACC Study

Overweight, obesity and fat distribution in 50- to 64-year-old participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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