Body size perceptions &amp; diet modification in youth with multiple sclerosis

Woolbright, Emma; Koshiya, Hitoshi; Brenton, J. Nicholas

doi:10.1016/j.msard.2021.103402

Cited by 2 publications

(4 citation statements)

References 34 publications

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“…Because of the high prevalence of overweight/obesity, and the evidence that obesity can worsen MS prognosis, education on weight management is still an unmet need, and non-guided patients are frequently no more likely to adopt a specific diet than normal weight patients [ 138 ]. Pediatric interventions may be even more hampered by the lack of self-perceived BMI elevation in MS youths [ 184 , 185 ]. Because there is, at present, no robust evidence, future research is also needed to identify appropriate study designs and intervention strategies targeting PA participation, with measurements of their outcomes on the primary and secondary symptoms of POMS [ 195 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, higher BMI is related to initial inflammation in the CSF in prepubertal patients with POMS suggesting an interaction between excess body fat, sexual hormones, and POMS occurrence [ 135 ]. These data are particularly worrying if one considers the findings that a large proportion of adolescents with POMS also have a non-self-perceived elevated BMI [ 184 ]. To improve their disease progression, they should therefore receive more accurate counseling to improve their diet [ 184 ] and physical activity as well [ 185 ].…”

Section: Diet and Nutrition Related Issues In Pediatric-onset Msmentioning

confidence: 99%

“…These data are particularly worrying if one considers the findings that a large proportion of adolescents with POMS also have a non-self-perceived elevated BMI [ 184 ]. To improve their disease progression, they should therefore receive more accurate counseling to improve their diet [ 184 ] and physical activity as well [ 185 ].…”

Section: Diet and Nutrition Related Issues In Pediatric-onset Msmentioning

confidence: 99%

See 2 more Smart Citations

Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics

Mandato,

Colucci,

Lanzillo

et al. 2023

Children

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Purpose. Lifestyle/dietetic habits play an important role in the development and progression of multiple sclerosis (MS) disease. Here, we examine the basic pathomechanisms underlying intestinal and brain barrier modifications in MS and consider diets and dietary supplementations proposed over time to complement pharmacological therapies for improving disease outcome both in adults and in children. Methods. Scoping literature search about evidence-based findings in MS-related gut-brain axis (GBA) pathophysiology and nutritional issues at all ages. Findings. Data show that (1) no universal best diet exists, (2) healthy/balanced diets are, however, necessary to safeguard the adequate intake of all essential nutrients, (3) diets with high intakes of fruits, vegetables, whole grains, and lean proteins that limit processed foods, sugar, and saturated fat appear beneficial for their antioxidant and anti-inflammatory properties and their ability to shape a gut microbiota that respects the gut and brain barriers, (4) obesity may trigger MS onset and/or its less favorable course, especially in pediatric-onset MS. Vitamin D and polyunsaturated fatty acids are the most studied supplements for reducing MS-associated inflammation. Conclusions. Pending results from other and/or newer approaches targeting the GBA (e.g., pre- and probiotics, engineered probiotics, fecal-microbiota transplantation), accurate counseling in choosing adequate diet and maintaining physical activity remains recommended for MS prevention and management both in adults and children.

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Section: Discussionmentioning

confidence: 99%

Section: Diet and Nutrition Related Issues In Pediatric-onset Msmentioning

confidence: 99%

Section: Diet and Nutrition Related Issues In Pediatric-onset Msmentioning

confidence: 99%

See 1 more Smart Citation

Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics

Mandato,

Colucci,

Lanzillo

et al. 2023

Children

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“…High BMI may be considered not only a risk factor but also a negative predictive fac-tor, as it appears to be associated with higher rates of relapse [10], development of disability [19], and negative response to disease-modifying drugs in terms of relapses under treatment [20]. Meanwhile, as evidence increases about this correlation, the prevalence of obesity in the MS pediatric population is growing at a rate of 25-50% compared to the past [21].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Onset Multiple Sclerosis and Obesity: Defining the Silhouette of Disease Features in Overweight Patients

Papetti,

Panella,

Monte

et al. 2023

Nutrients

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Obesity has been suggested as an environmental risk factor for multiple sclerosis (MS) and may negatively effect the progression of the disease. The aim of this study is to determine any correlation between overweight/obesity and the clinical and neuroradiological features at the onset of pediatric onset multiple sclerosis (POMS). Were included patients referred to the POMS Unit of the Bambino Gesù Children’s Hospital between June 2012 and June 2021. The diagnosis of MS with an onset of less than 18 years was required. For all included subjects, we considered for the analysis the following data at the onset of symptoms: general data (age, sex, functional system compromised by neurological signs, weight and height), brain and spinal magnetic resonance imaging (MRI), cerebrospinal fluid exams. We identified 55 pediatric cases of POMS and divided them into two groups according to the body mass index (BMI): 60% were healthy weight (HW) and 40% were overweight/obese (OW/O). OW/O patients experienced a two-year age difference in disease onset compared to the HW patients (12.7 ± 3.8 years vs. 14.6 ± 4.1 years; p < 0.05). Onset of polyfocal symptoms was seen more frequently in OW/O patients than in HW (72.7% vs. 21.2%; p < 0.05). The pyramidal functions were involved more frequently in the OW/O group than in the HW group (50% vs. 25%; p < 0.005). Black holes were detected more frequently in OW/O patients in onset MRI scans compared to the HW group (50% vs. 15.5%; p < 0.05). Our findings suggest that being overweight/obese affects the risk of developing MS at an earlier age and is associated with an unfavorable clinical–radiological features at onset. Weight control can be considered as a preventive/therapeutic treatment.

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Body size perceptions & diet modification in youth with multiple sclerosis

Cited by 2 publications

References 34 publications

Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics

Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics

Pediatric Onset Multiple Sclerosis and Obesity: Defining the Silhouette of Disease Features in Overweight Patients

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