Body size, reproductive factors, and breast cancer survival

Mohle-Boetani, Janet C.; Grosser, Stella; Whittemore, Alice S.; Malec, Mary; Kampert, James B.; Paffenbarger, Ralph S.

doi:10.1016/0091-7435(88)90056-4

Cited by 87 publications

(53 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although some studies have not supported this observation (Mohle Boetani et al, 1988;Lees et al, 1989;Ewertz et al, 1991), there is accumulating evidence that does support it (Greenberg et al, 1985;Kogevinas, 1990;Schouten et al, 1997 (MacMahon et al, 1970;Ewertz et al, 1990 (Ewertz et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Our study suggests that the postponement of motherhood might have a beneficial effect on overall breast cancer prognosis. Studies on overall parity as a prognostic factor have been contradictory (von Papatestas et al, 1980;Palmer et al, 1982;Black et al, 1983;Wang et al, 1985;Mohle-Boetani et al, 1988; Lees et al, 1989;Mason et al, 1990;Lehrer et al, 1992;Guinee et al, 1994;Korzeniowski and Dyba, 1994;Orr and Fraher, 1995;Schoultz et al, 1995). We have previously found that pregnancy within 2 years before a diagnosis of breast cancer was associated with reduced survival (Kroman et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Factors influencing the development of breast cancer might also affect its course, but studies of the prognostic influence of reproductive factors have been contradictory (Papatestas et al, 1980;Palmer et al, 1982;Black et al, 1983;Wang et al, 1985;Mohle Boetani et al, 1988;Lees et al, 1989;Mason et al, 1990;Lehrer et al, 1992;Guinee et al, 1994;Korzeniowski and Dyba, 1994;Off and Fraher, 1995;von Schoultz et al, 1995;Schouten et al, 1997). We took advantage of the population-based registration of breast cancer patients established by the Danish Breast Cancer Cooperative Group (DBCG) and a database containing complete information on parity to evaluate the possible importance of childbirth history and age at first birth as prognostic factors in primary breast cancer.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Parity, age at first childbirth and the prognosis of primary breast cancer

Kroman

Wohlfahrt²,

Andersen³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

Summary Reproductive factors are known to be aetiologically important in breast cancer, but less is known regarding their effect on breast cancer prognosis. We have investigated the prognostic effect of age at first birth and total parity using data from the Danish Breast Cancer Cooperative Group that, since 1977, has collected population-based information on tumour characteristics, treatment regimes and follow-up status on Danish women with breast cancer. Details of pregnancy history were added from the Danish Civil Registration System and the National Birth Registry. Included in the study were 10 703 women with primary breast cancer. After adjusting for age and stage of disease (tumour size, axillary nodal status and histological grading), the number of full-term pregnancies was found without prognostic value. However, women with primary childbirth between 20 and 29 years experienced a significantly reduced risk of death compared with women with primary childbirth below the age of 20 years [20-24 years: relative risk (RR) = 0.88, 95% confidence interval (Cl) 0.78-0.99; 25-29 years: RR = 0.80, 95% Cl 0.70-0.91]. Further adjustment for oestrogen receptor status did not influence these results. The effect was not modified by age at diagnosis, tumour size or nodal status. In conclusion, low age at first childbirth, but not parity, was associated with a poor prognosis of breast cancer. We speculate whether women who develop breast cancer despite an early first full-term pregnancy might represent a selected group with a more malignant disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Parity, age at first childbirth and the prognosis of primary breast cancer

Kroman

Wohlfahrt²,

Andersen³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…In addition to considering associations between BMI and details of cancer diagnosis (e.g., stage at diagnosis or other tumor characteristics) or initial treatment, the prognostic value of BMI within stage of diagnosis or treatment, for example, can also be considered. Previous research utilizing measures near diagnosis have found independent associations between larger body size and poorer breast cancer prognosis, with possible mechanisms related to hormones (e.g., excess leptin, insulin, or estrogen production), nutrition (e.g., dietary fat and caloric intake) or treatment (28)(29)(30)(31)(32). Specifically, overweight and obesity have been associated with chemotherapy dose reduction below that recommended for optimal treatment (33)(34)(35), which may subsequently impact survival due to poorer treatment efficacy (34,36).…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, overweight and obesity have been associated with chemotherapy dose reduction below that recommended for optimal treatment (33)(34)(35), which may subsequently impact survival due to poorer treatment efficacy (34,36). In addition, higher BMI has been found to be associated with increased axillary node involvement in postmenopausal women (37) and in women with ER-positive tumors (38), and has been associated with late-stage breast cancer diagnosis (29,(39)(40)(41).…”

Section: Discussionmentioning

confidence: 99%

Availability and utility of body mass index for population-based cancer surveillance

Keegan

McClure

et al. 2007

Cancer Causes Control

View full text Add to dashboard Cite

Objective-To evaluate the availability of body height and weight in the hospital medical record of cancer patients and discuss the utility of the findings to population-based cancer research and the surveillance of overweight and obesity in the United States.Methods-Medical records were reviewed for up to three measures of height and weight for a random sample of 1,739 patients diagnosed (2001)(2002)(2003) with one of 12 types of cancer and reported to the population-based Greater Bay Area Cancer Registry of Northern California.Results-84% of cancer patients had at least one value of height, 91% had at least one value of weight, and 83% had both values recorded in the medical record such that body mass index (BMI) could be computed. 60% of height and weight values were recorded within two months of cancer diagnosis, with most values (71%) recorded after cancer diagnosis. The availability of BMI varied somewhat by race/ethnicity, cancer site, initial treatment, and hospital characteristics.Conclusions-BMI may be sufficiently available to be included routinely in population-based cancer registries, and, if so, would be useful for studies of cancer diagnoses and outcomes and permit nationwide surveillance of BMI in a large population-representative cohort of cancer patients.

show abstract