Body weight, alcohol consumption and liver enzyme activity—a 4-year follow-up study

Lee, Duk-Hee; Ha, Myung-Hwa; Christiani, David C.

doi:10.1093/ije/30.4.766

Cited by 60 publications

(48 citation statements)

References 20 publications

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“…Among Australian adults, obesity accounted for half of the abnormal ALT levels in the study subjects, whereas excessive alcohol intake was responsible for o10% suggesting that excess weight is a greater risk factor of ALT levels than excessive alcohol consumption (Adams et al, 2008). In a 4-year follow-up study using Korean male workers aged 25-50 years, being overweight increased the risk of elevated ALT by 5-14-fold, but alcohol consumption was not related to ALT levels when adjusted for age, smoking, and exercise (Lee et al, 2001), which is consistent with the present finding. Studies conducted with Japanese adults have also reported that alcohol consumption was not significantly related to ALT (Nakamura, 1980;Nakamura et al, 1998).…”

Section: Discussionmentioning

confidence: 83%

“…In Korea, three studies on the relationship between obesity and elevated ALT concentration have been reported (Lee et al, 2001;Sung et al, 2007;Song et al, 2008). However, these studies were limited to specific groups of Korean subjects; one study used only men (Lee et al, 2001), whereas the other involved only obese women who had visited the hospital for the management of their obesity .…”

Section: Introductionmentioning

confidence: 99%

“…However, these studies were limited to specific groups of Korean subjects; one study used only men (Lee et al, 2001), whereas the other involved only obese women who had visited the hospital for the management of their obesity . Further limiting the value of these studies was their failure to consider alcohol intake, which is a potential risk factor of elevated ALT concentration (Lee et al, 2001;Sung et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Kim

2009

Eur J Clin Nutr

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Background/Objectives: Obesity has been identified as an important factor of elevated alanine aminotransferase (ALT), a surrogate of non-alcoholic fatty liver disease. We investigated the relationship between obesity and elevated ALT in the general Korean population. Subjects/Methods: The study sample was comprised of 3098 Korean adults who had participated in the 2005 Korean National Health and Nutrition Examination Survey. Obesity was assessed using body mass index (BMI). Overweight (23pBMIo25) and obese (BMIX25) were defined by the International Obesity Task Force for Asian adults. ALT was measured by enzymatic methods. Elevated ALT was defined as an enzyme activity 440 IU/l for men and 431 IU/l for women. Results: Among participants, 246 (12.7%) men and 86 (7.4%) women displayed elevated ALT. BMI was significantly higher in men and women with elevated ALT than those with normal ALT (Po0.0001). The unadjusted odds ratio (OR) for elevated ALT increased according to the degree of BMI in men (OR: 1.9, 95% confidence interval (CI): 1.25-2.93 in overweight vs OR: 5.01, 95% CI: 3.49-7.21 in obese; Po0.0001) and women (OR: 2.44, 95% CI: 1.24-4.82 vs OR: 3.94, 95% CI: 2.18-7.13; Po0.0001). This trend did not differ after adjustment for putative risk factors including alcohol intake in men (OR: 1.56 vs OR: 3.47, Po0.0001) and women (OR: 1.55 vs OR: 3.10, P ¼ 0.0015). Conclusion: BMI is implicated as a strong risk factor of elevated ALT in non-diabetic Korean adults.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Kim

2009

Eur J Clin Nutr

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“…In fact, obesity is the most likely cause of a raised ALT in men [16] while alcohol was the more likely cause of an elevated ALT in women. Thus ALT is a more sensitive and specific marker of liver disease than AST.…”

Section: Transaminasesmentioning

confidence: 99%

Review and Recommendations for the Component Tests in the Liver Function Test Profile

Badrick

Turner

2015

Ind J Clin Biochem

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Pathology laboratories group some tests that they perform on their high throughput biochemistry analysers into profiles of tests that are associated with different organs (e.g. liver function tests-LFT). The components of these profiles are historic and often vary between different laboratories. This can lead to confusion and begs the question of what should be in a particular profile. In community medicine profiles may be used as screening tests but some of the components of the profiles may have low sensitivity and specificity and may produce both false positives and negatives. The LFT may include components which are poor liver function tests but are sensitive to fatty liver and hence elevations may cause unnecessary concern. Harmonisation of clinical chemistry reference intervals and units is occurring now so it is time to consider a similar process for components of a profile. A proposed list of analytes to be performed in the LFT profile is given.

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“…direta entre a prática de atividade física e a redução das aminotransferases em etilistas, sendo que os níveis dessas enzimas variam de acordo com múltiplos fatores, como o índice de massa corporal e a idade [22][23][24] . Diversos autores 3,6,7,10,11 tentam demonstrar os mecanismos envolvidos na injuria hepática causada pelo álcool que corroboram para a elevação plasmática das aminotransferases.…”

Section: Figura 2 Distribuição Dos Valores De Fosfatase Alcalina Nosunclassified

Consumo De Álcool E a Influência Do Exercício Físico Na Atividade Enzimática De Ratos Wistar

Righi

Carvalho

Ribeiro

et al. 2016

Rev Bras Med Esporte

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RESUMOIntrodução: Biomarcadores vem sendo utilizados para monitorar o uso do álcool e, atualmente, os mais sensíveis e específicos são enzimas hepáticas, por exemplo, gama glutamiltransferase (GGT), alanina aminotransferase (ALT), aspartato aminotransferase (AST) e fosfatase alcalina (ALP). Objetivo: Verificar, a partir da experimentação animal, as alterações provocadas pelo uso de álcool e pela prática de atividade física nas enzimas hepáticas e pancreáticas. Métodos: Vinte e quatro ratos da linhagem Wistar foram distribuídos aleatoriamente em grupos experimentais, alojados em gaiolas com ambiente controlado, divididos de acordo com os tratamentos recebidos. No tratamento inicial, foi administrado álcool aos grupos álcool sedentário (AS) e álcool exercitado (AE) e, ao final da quarta semana, iniciou-se o programa de treinamento físico em esteira com os grupos AE e controle exercitado (CE). A coleta de sangue foi realizada por punção cardíaca ao final de cada experimento. Na análise estatística, utilizou-se teste de análise de variância (ANOVA) seguido de teste de Tukey e teste de Kruskal-Wallis. Resultados: O grupo AS apresentou valores significativamente mais elevados de ALT e ALP quando comparado aos grupos CE e AE, respectivamente. Não foram observadas diferenças significativas entre os quatro grupos estudados para os parâmetros AST, GGT e amilase. Conclusão: A associação entre consumo de álcool e sedentarismo aumentou a liberação das enzimas ALT e ALP em ratos Wistar; a prática de exercício físico aeróbico após abstinência alcoólica evitou o aumento da liberação de ALP no plasma desses animais.Descritores: alcoolismo/enzimologia, atividade motora, ratos Wistar. ABSTRACT Introduction: Biomarkers have been used to monitor the use of alcohol and currently the most sensitive and specific are the liver enzymes, for example, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP

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Body weight, alcohol consumption and liver enzyme activity—a 4-year follow-up study

Cited by 60 publications

References 20 publications

Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults

Review and Recommendations for the Component Tests in the Liver Function Test Profile

Consumo De Álcool E a Influência Do Exercício Físico Na Atividade Enzimática De Ratos Wistar

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