Body weight and growth rates throughout the guinea pig pregnancy: Evidence for modulation by endogenous estrogens☆

Alteration of Ingestive Behavior and Plasma Metabolites by Estrogen in Ovariectomized Goats.

“…These results confirm the previous suggestion that the lowered food intake normally seen at estrus [5] or in late pregnancy [2] in ruminants is caused by high titers of E secreted by the ovary or placenta. Because it has been known that E modulates ingestive behavior in a variety of species [6][7][8][9][10][11], a conserved mechanism may exist across mammalian species for the estrogenic control of ingestion regardless of different ingestive systems. On the other hand, unlike rats [24], we were not able to see any effect of P on food intake in the goat (Fig.…”

“…The roles of steroid hormones have been well documented in nonruminant species such as rats [6][7][8], guinea pig [9], rhesus monkey [10] and human [11]. It has been thought that the decrease in food intake at estrus is due to an action of estrogen, because ovariectomy results in hyperphagia and this effect can be reversed by treatment with estrogen [7,8].…”

Targeted Drug Delivery

“…Estrogens are known to affect body weight and the Ez-CDS was therefore examined as a potential anorexigenic (WADE 1972;LANDAU and ZUCKER 1976;CZAJA 1983). The effects of Ez-CDS on food intake and body weight have been evaluated in male rats which were sexually mature, in 9month-old male rats whose obesity was age-related, and in female rats (SIMPKINS et al 1988(SIMPKINS et al , 1989ANDERSON et al 1988b;ESTES et al 1988;SARKAR et al 1989).…”