Body weight and waist circumference as predictors of vitamin D deficiency in patients with type 2 diabetes and cardiovascular disease

Kavaric, Sreten; Vuksanovic, Milica; Bozovic, Dragica; Jovanovic, Marko; Jeremić, Veljko; Radojičić, Zoran; Pekić, Sandra; Popović, Vera

doi:10.2298/vsp110713035k

Cited by 19 publications

(18 citation statements)

References 41 publications

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“…In addition, extended socioeconomic transition corresponded to high prevalence of other common chronic diseases, which additionally affected community health status in an adverse direction (21). It has been recently demonstrated that markers of nutritional pattern relating to obesity represented a strong predictor for vitamin D deficiency in patients with chronic, metabolic disease (22). Other researchers in Serbia found that the mean serum concentrations of 25-hydroxyvitamin D were much below the threshold in an apparently healthy (student) population (23).…”

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confidence: 99%

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Ristic

Živanović

Milovanovic

et al. 2017

J Nutr Sci Vitaminol

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SummaryThis research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical analysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium). Data were analyzed using descriptive statistics, methods for hypothesis testing and binary logistic regression, at the p#0.05 level. A total of 140 patients (64%) had a deficiency of vitamin D (,12 ng/mL), and 45 (20%) had inadequate vitamin D serum levels (12-20 ng/mL), while 35 (16%) had sufficient vitamin D serum concentrations (.20 ng/mL). Among variables related to demographics, life style habits, mental illness, comorbid disorders and drugs, two of them, female gender (odds ratio (OR)52.5, 95% confidence interval (CI)51.3-4.9, p50.006) and using clozapine (OR515.6, 95% CI 1.7-144.7, p50.02), were significantly associated with vitamin D deficiency. Physical activity (OR5 0.4, p50.02), exercising (OR50.2, 95% CI , p50.02) and offal in the diet (OR50.5, 95% CI 0.3-0.9, p50.03) significantly aggregated in the patients who had a 25(OH)D serum concentration above the deficiency cut-off level. Patients with mental disorders are at high risk for vitamin D deficiency, particularly females and clozapine users as well as those having no adequate physical activity or dietary habits.

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confidence: 99%

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Ristic

Živanović

Milovanovic

et al. 2017

J Nutr Sci Vitaminol

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“…Eleven studies covering 2236 patients and 2438 controls were employed to metaanalyze the 25(OH)D levels in T2D patients . Six studies were conducted in Asia, and five in Europe.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the exclusion of the two studies by Al‐Daghri et al. also changed the summary SMD largely (Fig. B), which should result from the observed relatively higher vitamin D levels in T2D patients than controls in the two studies.…”

Section: Resultsmentioning

confidence: 99%

“…The potentially relevant references were identified by reviewing titles and/or abstracts, and/or full text of all citations identified with database searches. Out of 763 initial hits, 12 and 11 eligible studies were finally included in the metaanalysis of vitamin D levels in T1D and T2D patients, respectively. Ten studies were excluded for not providing exact standard deviation values of serum 25(OH)D levels in T1D or T2D patients .…”

Section: Methodsmentioning

confidence: 99%

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Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis

Shen

Zhuang

2016

Molecular Nutrition Food Res

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“…One of the indirect indicators of visceral adipose tissue is considered to be the waist circumference (WC). In a systematic review (17 prospective and 35 cross-sectional studies reviewed) published in 2010, it was reported that the ratio of BMI, WC and WC/hip circumference could predict diabetes risk independently of each other [11]. BMI is considered to have less sensitivity than WC [12].…”

Section: Introductionmentioning

confidence: 99%

Uric Acid and GGT Have Causal Relations with Abdominal Obesity: A Real-Life Research in Turkish Population with 1214 Diabetics

Avcı¹,

Çetinkaya²

2019

JBM

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Aim: We compared the waist circumferences (WC) of 1214 diabetics with various parameters in real-life conditions. Patients and Method: The study was carried out by reviewing the anthropometric measurements and biochemical analyzes of diabetics and they were analyzed due to WC status of the patients. Results: Mean total cholesterol level was 204.6 ± 47.1 mg/dL in patients with normal WC and 211.6 ± 45.6 mg/dL in patients with increased WC (p = 0.015). Total cholesterol was found to be a risk factor for WC enlargement (OR: 1.003, 95% CI: 1.001-1.006, p = 0.015). HDL-cholesterol appeared to be a risk factor for the increase in WC (OR: 1.005, CI: 1.001-1.010, p = 0.029). Median triglyceride level was 158 (41-975) mg/dL in the normal WC group, while it was 176 (22-1379) mg/dL in the patients with increased WC (p < 0.001). Triglyceride was observed as a risk factor for WC increase (OR: 1.002, 95% CI: 1.001-1.003, p = 0.004). The serum uric acid level was 4.75 ± 1.6 mg/dL in the normal WC group, while it was 5.09 ± 1.5 mg/dL in the increased WC group (p = 0.002). Serum uric acid level was appeared as a risk factor for increased WC (OR: 1.162, 95% CI: 1.057-1.276, p = 0.002). The median serum GGT level was 27 (7-174) mg/dL in WC normal group and 28 (8-730) mg/dL in increased WC diabetics (p = 0.029). Serum GGT level was a risk factor for increased WC (OR: 1.162, 95% CI: 1.001-1.010, p = 0.029). Conclusion: We have demonstrated that the measurement of WC has an important role in diabetes management and is related with inflammatory parameters such as uric acid and GGT.

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Body weight and waist circumference as predictors of vitamin D deficiency in patients with type 2 diabetes and cardiovascular disease

Abstract: The high prevalence of vitamin D deficiency in patients with T2DM and particularly in patients with T2DM and CVD suggests that supplementation with vitamin D may be beneficial although there is still not sufficient evidence for recommending prescribing vitamin D.

Cited by 19 publications

References 41 publications

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis

Uric Acid and GGT Have Causal Relations with Abdominal Obesity: A Real-Life Research in Turkish Population with 1214 Diabetics

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