Body Weight, Body Mass Index, and Incident Symptomatic Osteoarthritis of the Hand, Hip, and Knee

Oliveria, Susan A.; Felson, David T.; Cirillo, Priscilla A.; Reed, James W.; Walker, Alexander M.

doi:10.1097/00001648-199903000-00013

Cited by 392 publications

(274 citation statements)

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“…[42][43][44] The current results provide further support that leptin may have a role in OA as a significant relationship was observed in self-reported physical function and stiffness measures with the hormone. Higher leptin concentrations were related to greater impairments in self-reported measures of physical function.…”

Section: Discussionsupporting

confidence: 77%

Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?

et al. 2004

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OBJECTIVE:To determine the effect of weight loss and exercise interventions on serum leptin and to investigate the relationship of physical function and osteoarthritis (OA) severity with serum leptin in older overweight and obese adults with knee OA. In addition, the study examined if serum leptin predicts weight loss. DESIGN: Longitudinal, controlled clinical trial of weight loss and exercise interventions. SUBJECTS: Community dwelling, older, overweight and obese adults (n ¼ 316; 460 years of age; body mass index Z28.0 kg m À2 ) with symptomatic knee OA and self-reported difficulty in performing selected physical activities were recruited. INTERVENTIONS: Participants were randomized into one of four groups for the 18-month study duration: Healthy Lifestyle Controls, Dietary Weight Loss (Diet), Exercise Training (Exercise), and a combination of Dietary Weight Loss and Exercise Training (Diet þ Exercise). The weight loss goal for the two Diet groups was 5% from baseline at 18 months. Participants in the Exercise groups were trained for 3 days week À1 , 60 min day À1 . MEASUREMENTS: Body weight, body mass index, serum leptin, physical function, and OA severity were measured at baseline, 6 months, and 18 months. RESULTS: Diet and Diet þ Exercise groups lost 5.3 and 6.1% of their weight, respectively, at 18 months with the Exercise group losing 2.9%. There was a significant main effect of weight loss on serum leptin with a decrease in serum leptin averaged across the 6-and 18-month time points for the Diet and Diet þ Exercise groups compared to the other two groups (b ¼ 0.245; Po0.01). No main effect for exercise training was observed. Serum leptin was related to self-reported physical function. In all participants, a mixed model analysis demonstrated that lower levels of baseline serum leptin predict larger weight loss (b ¼ À2.779; P ¼ 0.048). CONCLUSION: Decreases in serum leptin may be one mechanism by which weight loss improves physical function and symptoms in OA patients.

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Section: Discussionsupporting

confidence: 77%

Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?

et al. 2004

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“…Several cross-sectional studies have consistently described an increased risk of knee OA in overweight and obese elderly subjects. [105][106][107][108] In data from NHANES I, obese men and women had 4.8-and 4-fold increased risks, respectively, of OA compared to normalweight subjects. 105 Similarly, in the Baltimore Longitudinal Study on Aging, subjects in the highest tertile of BMI showed an increased risk of both unilateral and bilateral knee OA.…”

Section: Obesity and Aging M Zamboni Et Almentioning

confidence: 99%

Health consequences of obesity in the elderly: a review of four unresolved questions

et al. 2005

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Obesity prevalence is growing progressively even among older age groups. Controversy exists about the potential harms of obesity in the elderly. Debate persists about the relation between obesity in old age and total or disease-specific mortality, the definition of obesity in the elderly, its clinical relevance, and about the need for its treatment. Knowledge of age-related body composition and fat distribution changes will help us to better understand the relationships between obesity, morbidity and mortality in the elderly. Review of the literature supports that central fat and relative loss of fat-free mass may become relatively more important than BMI in determining the health risk associated with obesity in older ages. Weight gain or fat redistribution in older age may still confer adverse health risks (for earlier mortality, comorbidities conferring independent adverse health risks, or for functional decline). Evaluation of comorbidity and weight history should be performed in the elderly in order to generate a comprehensive assessment of the potential adverse health effects of overweight or obesity. The risks of obesity in the elderly have been underestimated by a number of confounders such as survival effect, competing mortalities, relatively shortened life expectancy in older persons, smoking, weight change and unintentional weight loss. Identification of elderly subjects with sarcopenic obesity is probably clinically relevant, but the definition of sarcopenic obesity, the benefits of its clinical identification, as well as its relation to clinical consequences require further study. Studies on the effect of voluntary weight loss in the elderly are scarce, but they suggest that even small amounts of weight loss (between 5-10% of initial body weight) may be beneficial. In older as well as in younger adults, voluntary weight loss may help to prevent the adverse health consequences of obesity.

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“…Preeminent among these are familial linkages and obesity, themselves interlinked. Bad genes are important and while mechanical loading can be argued to be an obvious etiological factor in hip or knee OA, how can it be in hand OA [28,29]? Further, hand OA itself is associated with cardiovascular disease [30] and an increased risk of diabetes mellitus [31].…”

Section: Oa Is Not a Benign Diseasementioning

confidence: 99%

Osteoarthritis revisited—again!

Watt

2009

Skeletal Radiol

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Body Weight, Body Mass Index, and Incident Symptomatic Osteoarthritis of the Hand, Hip, and Knee

Cited by 392 publications

References 0 publications

Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?

Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?

Health consequences of obesity in the elderly: a review of four unresolved questions

Osteoarthritis revisited—again!

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