Body Weight Variability and Cardiovascular Health in Diabetes

Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial (Diabetes Metab J 2022;46:767-80)

“…Second, weight gain in patients with T2DM who were already obese indicates that the patients progressed to a more obese state, which is definitely associated with a higher risk of complications. Finally, “weight cycling” may be responsible for the negative effects of weight change [ 7 ]. Short-term weight reduction accomplished through diet modification followed by gradual weight increase promotes preferential visceral fat accumulation.…”