Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β‐catenin signalling

Bak, Dong‐Ho; Lee, Esther; Lee, Byung‐Chul; Choi, Mi Ji; Kwon, Tae‐Rin; Kim, Jong‐hwan; Park, Byung Cheol; Lee, Keugrae; Kim, Sungyup; Na, Jungtae; Kim, Beom Joon

doi:10.1111/exd.14051

Cited by 11 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, better understanding of the mechanisms of hair loss is needed to fully explain the genetic basis of hair loss via suitable animal models, such as C3H/HeJ mice and human skin xenotransplants on SCID mice, which may direct the screening of more effective therapeutic agents as well as the exploration of new targeted therapeutic alternatives. ,,− Second, it is essential to thoroughly evaluate the efficacy and safety of currently developed drug delivery systems in hair loss therapy. − Third, synergistic combinations of penetration enhancers and drug delivery systems might be an efficient way to achieve the full potential of topical treatment …”

Section: Discussionmentioning

confidence: 99%

Transdermal Drug Delivery for Hair Regrowth

Yang

Chen

2020

Mol. Pharmaceutics

View full text Add to dashboard Cite

Today, about 50% of men and 15–30% of women suffer from hair loss as well as the associated psychological impact. Drug therapy, especially through topical administration, is the main treatment strategy for stimulating hair regrowth. However, challenges exist due to the skin barrier that hinders drug penetration. To this end, many efforts have been made to enhance drug penetration efficiency. This review focuses on the advancement of the transdermal drug delivery strategies for hair loss therapy reported in the last five years, especially those via nanoformulations for topical administration and microneedles for transdermal delivery. In addition, physical or chemical penetration enhancers are also introduced, which are often applied with the drug delivery systems to achieve a synergy effect.

show abstract

Section: Discussionmentioning

confidence: 99%

Transdermal Drug Delivery for Hair Regrowth

Yang

Chen

2020

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…DPCs are believed to direct the HFs morphogenesis and precisely regulate their cycling (39). Studies report that the cytokines or biological agents treated DPCs induced hair growth, which has always been related with the activation of Wnt (40). Application of 3-Deoxysappanchalcone on C57BL/6 mice and DPCs resulted in anagen transition, hair growth and cell proliferation (41).…”

Section: Discussionmentioning

confidence: 99%

Concentrated nanofat: a modified fat extraction promotes hair growth in mice via the stem cells and extracellular matrix components interaction

Zhang

et al. 2020

Ann Transl Med

View full text Add to dashboard Cite

Background: Fat graft transplantation seems a promising cell therapy for hair loss. However, impurities in lipoaspirate weaken the treatment effect. Here, we developed the lipoaspirate extraction method then investigate the effect and mechanism on hair growth-promoting in a mouse model. Methods: Fat graft was prepared into concentrated nanofat (CNF), decellularized CNF (DCNF), and adipose-derived stem cells (ADSCs). They were injected subcutaneously in the back of depilated mice to test the hair promoting effect. Conditioned media (CM) from the adipose extracts were applied to dermal papilla cells (DPCs) to evaluate the cell viability and the anagen related signal.Results: CNF and a high dose of ADSCs promoted hair growth and induced telogen-to-anagen transition in depilated mice. DCNF and a low dose of ADSCs did not show such effect; however, hair growth was promoted when they were used in combination. In vitro study showed the CNF-CM treated DPCs exhibited increased proliferation, migration, cell cycle progression, and elevated Wnt/β-catenin pathway protein levels compared with the other treatment groups.Conclusions: CNF has a better effect than ADSCs in hair promotion via activating the DPCs and anagen induction. In this nature complex of stem cells (SCs) and extracellular matrix (ECM), ECM serves a significant supplementary role and amplifies the power of ADSCs. These results supply a theoretical basis on the clinical application of CNF to treat hair loss.

show abstract

“…hDPCs (1.5×10 5 ) were seeded into 6-well plates for 24 h, followed by treatment with Vehicle control (1% DMSO), minoxidil (10 μM), and CGE (3.1–50 μg/mL) for 24 h. ALP activity was analyzed using the SensoLyte ® pNPP Alkaline Phosphatase Assay Kit (Cat no. AS-72146, AnaSpec, Inc., Fremont, CA, USA) as previously described [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity

et al. 2022

View full text Add to dashboard Cite

To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additionally, hair growth evaluation was carried out following topical treatment of the dorsal skin of telogen C57BL/6 mice with CGE for 14 days. As result, CGE increased cell viability and ALP activity in hDPCs. Moreover, CGE increased the expression of catenin beta 1 (CTNNB1), ALP, sex-determining region Y-box 2 (SOX2), insulin-like growth factor 1 (IGF1), and vascular endothelial growth factor A (VEGFA) genes in hDPCs. CGE increased the expression of proteins such as ALP, β-catenin, and phosphorylation of glycogen synthase kinase 3β (pGSK3β), and protein kinase B (pAKT) in hDPCs. Furthermore, CGE induced the proliferation of HaCaT cells and up-regulated AKT-ERK-GSKβ-β-catenin signaling in HaCaT cells. Additionally, the anagen induction effects of CGE were confirmed on the telogen-anagen transition mice model. these findings demonstrated that CGE promoted the entering the growth phase of hair follicle via activation of β-catenin signaling pathways in vivo. Thus, this study suggests that CGE might be a potential therapeutic reagent for hair growth.

show abstract

Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β‐catenin signalling

Cited by 11 publications

References 46 publications

Transdermal Drug Delivery for Hair Regrowth

Transdermal Drug Delivery for Hair Regrowth

Concentrated nanofat: a modified fat extraction promotes hair growth in mice via the stem cells and extracellular matrix components interaction

The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity

Contact Info

Product

Resources

About