In the study, it was aimed to present the current situation of Technology Transfer Offices (TTO) and their examples in different countries, to give information about the pioneering studies of the Health Institutes of Türkiye (TUSEB) in the field of health science and technologies, to include the scope, duties and the organizational structure, stakeholders and the holistic studies of TUSEB TTO carries out. TUSEB TTO, which continues its activities within a strategic plan that takes into account the development plan objectives and the priorities determined by the Presidency and the Ministry of Health; prioritizes objectives such as meeting Türkiye's need for advanced technology and innovation in the field of health science and technologies, and supporting all processes from idea to product. In addition, TUSEB TTO is a health-focused coordination center where health professionals, engineers, academicians, and students with innovative ideas, as well as various public institutions, investors, universities, technoparks, incubation centers, and important organizations such as active institutions and NGOs can collaborate. TUSEB TTO plays an active role in the creation of the health innovation ecosystem with its activities such as leading studies in the field of health science and technologies, raising awareness with trainings that will cover all processes of health innovation, coordinating innovative ideas at all stages leading to the product, and creating the necessary collaborations.