BOLD-MRI early detect femoral head osteonecrosis following steroid-treated patients

Li, Jing; Wang, Jingjing; Zhao, Jianhua; Yuan, Bin; Xing, Liming; Tang, Fengming; Liu, Lei; Lu, Mingming; Zhang, Quan; Zhao, Jun; Gu, Ping; Li, Jianhui; Zhang, Zhuoli; Sun, Chia‐Chung; Yuan, Fei

doi:10.1097/md.0000000000008401

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…In addition, microparticles in blood are associated with the disease 16 . The association of coagulation and vasoconstriction is also supported by histopathology and MRI-BOLD as well as blood velocity studies 50 . Hence multiple factors at the genetic, transcriptomic, metabolomic or at the level of cofactors might contribute to coagulation cascade which is associated with AVNFH.…”

Section: Discussionmentioning

confidence: 78%

Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease

Naik

Narayanan

Khanchandani

et al. 2020

Sci Rep

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Avascular necrosis of femoral head (AVNFH) is a debilitating disease, which affects the middle aged population. Though the disease is managed using bisphosphonate, it eventually leads to total hip replacement due to collapse of femoral head. Studies regarding the association of single nucleotide polymorphisms with AVNFH, transcriptomics, proteomics, metabolomics, biophysical, ultrastructural and histopathology have been carried out. Functional validation of SNPs was carried out using literature. An integrated systems analysis using the available datasets might help to gain further insights into the disease process. We have carried out an analysis of transcriptomic data from GEO-database, SNPs associated with AVNFH, proteomic and metabolomic data collected from literature. Based on deficiency of vitamins in AVNFH, an enzyme-cofactor network was generated. The datasets are analyzed using ClueGO and the genes are binned into pathways. Metabolomic datasets are analyzed using MetaboAnalyst. Centrality analysis using CytoNCA on the data sets showed cystathionine beta synthase and methylmalonyl-CoA-mutase to be common to 3 out of 4 datasets. Further, the genes common to at least two data sets were analyzed using DisGeNET, which showed their involvement with various diseases, most of which were risk factors associated with AVNFH. Our analysis shows elevated homocysteine, hypoxia, coagulation, Osteoclast differentiation and endochondral ossification as the major pathways associated with disease which correlated with histopathology, IHC, MRI, Micro-Raman spectroscopy etc. The analysis shows AVNFH to be a multi-systemic disease and provides molecular signatures that are characteristic to the disease process.

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Section: Discussionmentioning

confidence: 78%

Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease

Naik

Narayanan

Khanchandani

et al. 2020

Sci Rep

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“…Although femoral head osteonecrosis was frequently observed among patients with SARS who were treated with high-dose glucocorticoids in 2003, a significantly lower cumulative dose and prolonged course of COVID-19 treatment was administered compared to the recommended glucocorticoid doses in SARS treatment. It is therefore prudent to perform risk stratification based on supraphysiologic glucocorticoid dosing provided during the course of COVID-19 treatment and to potentially perform magnetic resonance imaging on those patients with suspected avascular necrosis of the hip [ 77 ]. Figure 1 demonstrates the proposed relationship of COVID-19 with osteoporosis as described below.…”

Section: Covid-19 and Glucocorticoid Treatmentmentioning

confidence: 99%

COVID-19 Pandemic and Osteoporosis in Elderly Patients

Tang¹

2022

Aging and disease

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Coronavirus disease 2019 (COVID-19), which is caused by an infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly becoming a worldwide epidemic and poses a significant threat to human life and health. SARS-CoV-2 can cause damage to organs throughout the body through ACE2 receptors. It may have direct and indirect effects on osteoclasts, and osteoblasts and lead to osteoporosis. Vitamin D (VitD) is a key hormone for bone health and has immunomodulatory actions of relevance in the context of the COVID-19 pandemic. Vitamin D deficiency has a significant positive association with both infection and the mortality rate of COVID-19. Elderly patients infected by COVID-19 were more likely to develop acute respiratory distress syndrome (ARDS), which was primarily caused by an inflammation storm. The production of proinflammatory cytokines increases with COVID-19 infection and immobilization may result in bone loss and bone resorption in seriously ill patients, especially aging patients. It is well known that glucocorticoids are beneficial in the treatment of acute respiratory distress syndrome (ARDS) because they reduce inflammation and improve the functioning of the lung and extrapulmonary organs. Glucocorticoid therapy is widely used to treat patients with COVID-19 in most parts of the world. During COVID-19 clinical treatment, glucocorticoids may accelerate bone loss in elderly people, making them more susceptible to the development of osteoporosis. Therefore, it is worthwhile to draw the attention of clinicians and researchers to the linkages and interactions between COVID-19, glucocorticoids, and osteoporosis (especially in elderly patients).

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“…Finally, we fully agree that clinicians who care for COVID-19 patients who have received high-dose glucocorticoids should be aware of potential skeletal complications with such therapy and should evaluate those patients with suspected avascular necrosis of the hip with magnetic resonance imaging. (6)…”

Section: To the Editormentioning

confidence: 99%