Bombay Blood Group and Pregnancy

Abstract

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Role of Acute Normovolemic Hemodilution in Pregnancy for Emergency Cesarean Section in a Patient With Bombay Blood Group

“…The Bombay blood group, otherwise known as the h/h or Oh group, is seen in about one in 10,000 individuals in India and is one of the rarest blood groups found [ 6 ]. Patients with this blood group are devoid of A, B, or H antigens in their cells and are known to have high titers of anti-H antibodies, which can result in significant fetal and maternal hemolysis if blood other than the Bombay phenotype is transfused [ 7 ]. Literature on patients with the Bombay blood group is scarce, with a few case reports describing the management of such patients during pregnancy.…”

Navigating the challenges of Bombay phenotype (Oh) and twin pregnancy; a case report and literature review

“…Studies describing antenatal management of Bombay patients are limited. There are 11 published reports [7][8][9][10][11][12][13][14][15][16][17] with only one having twins. 14 Pleasingly, all mothers and all except one baby 12 survived the delivery and neonatal challenges of Bombay phenotype.…”

“…There are 11 published reports [7][8][9][10][11][12][13][14][15][16][17] with only one having twins. 14 Pleasingly, all mothers and all except one baby 12 survived the delivery and neonatal challenges of Bombay phenotype. Initial management should be employing patient blood management strategies including optimizing red cell mass, minimizing blood loss, and maximizing tolerance of anemia.…”

“…19 In one case, two doses of erythropoietin were also employed to optimize hemoglobin pre-delivery. 11 Anti-H can cause HDFN however this is uncommon -1 out of 4 pregnancies in one study 20 and 4/19 across all case reports [7][8][9][10][11][12][13][14][15][16][17] and adverse outcomes are exceedingly rare. The antibody titer does not reliably predict its occurrence or severity.…”