Bombyx mori from a food safety perspective: A systematic review

Marzoli, Filippo; Antonelli, Pietro; Saviane, Alessio; Tassoni, Luca; Cappellozza, Silvia; Belluco, Simone

doi:10.1016/j.foodres.2022.111679

Cited by 19 publications

(11 citation statements)

References 81 publications

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“…This research illuminates the molecular intricacies underpinning silkworms’ response and adaptation to heavy-metal stress. Moreover, our findings may inspire the formulation of efficacious breeding strategies that bolster the resilience of B. mori and other agriculturally vital insects against heavy metal pollution [ 17 , 25 , 26 , 37 ]. In the grander scheme, our study has the potential to extend the current understanding of Chromium toxicity and provide vital insights for preserving the ecological fitness of silkworms and enhancing their survival capabilities in the face of environmental toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…However, hexavalent Chromium is predominantly released into the atmosphere through human activities and can contaminate air and drinking water sources [ 11 , 12 , 14 , 15 ]. Therefore, finding breeds more resistant to heavy metal stress is a long-term goal of scientific breeding [ 16 , 17 ]. Secondly, the high-quality silkworm reference genome has already been sequenced, providing a solid foundation for studying gene expression changes under Chromium exposure [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Chromium Exposure on the Gene Expression of the Midgut in Silkworms, Bombyx mori

Rong

Chen

Jiang

et al. 2023

Genes

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Chromium is a severe heavy metal pollutant with significant environmental risks. The effects of Chromium on the digestion of Bombyx mori (silkworms) are of particular importance due to their ecological and economic significance. Herein, RNA sequencing was conducted on nine midgut samples from silkworms exposed to control, 12 g/kg and 24 g/kg Chromium chemical diets. Comparative transcriptomics revealed that under moderate Chromium exposure, there was a significant increase in up-regulated genes (1268 up-regulated to 857 down-regulated), indicating a stimulation response. At higher stress levels, a weakened survival response was observed, with a decrease in up-regulated genes and an increase in down-regulated genes (374 up-regulated to 399 down-regulated). A notable shift in cellular responses under medium chromium exposure was exposed, signifying the activation of crucial metabolic and transport systems and an elevation in cellular stress and toxicity mechanisms. The observation of up-regulated gene expression within xenobiotic metabolism pathways suggests a heightened defense against Chromium-induced oxidative stress, which was primarily through the involvement of antioxidant enzymes. Conversely, high-dose Chromium exposure down-regulates the folate biosynthesis pathway, indicating biological toxicity. Two novel genes responsive to pressure were identified, which could facilitate future stress adaptation understanding. The findings provide insights into the molecular mechanisms underlying silkworms’ digestion response to Chromium exposure and could inform its biological toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Chromium Exposure on the Gene Expression of the Midgut in Silkworms, Bombyx mori

Rong

Chen

Jiang

et al. 2023

Genes

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“…Due to their great numbers and species richness, edible insects have been widely used as resources for nutrition, and insect-based nutritional or dietary supplements have a great market potential Bombyx mori, an economic insect being used for silk production for more than 4000 years in Asia, is one of the most popular edible insects . Silkworm pupae, the nymph stage of B.…”

Section: Introductionmentioning

confidence: 99%

“…1 Bombyx mori, an economic insect being used for silk production for more than 4000 years in Asia, is one of the most popular edible insects. 2 Silkworm pupae, the nymph stage of B. mori, are rich in nutrients including proteins, lipids, chitosan, vitamins, and other nutrients. 3 Hence, except for being used as animal feed, silkworm pupae have also been widely consumed as human food in Asian countries, such as Korea, Thailand, India, and especially China.…”

Section: ■ Introductionmentioning

confidence: 99%

Purification, Immunological Identification, and Characterization of the Novel Silkworm Pupae Allergen Bombyx mori Lipoprotein 3 (Bomb m 6)

Yue,

Huang,

Lin

et al. 2023

J. Agric. Food Chem.

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“…In every case, to be defined as food, insects need to be safe with respect to foodborne hazards. Despite traditional consumption of insects not having highlighted safety concerns, as far as we know, beyond allergic reactions 1 , 6 , 7 , the scaling up of insect farms and processing plants calls for data on the behavior of foodborne pathogens in these conditions. Among the risks associated with the consumption of insects is the possible presence of foodborne pathogens, with the level of risk mainly dependent on the farming substrate 1 .…”

Section: Introductionmentioning

confidence: 99%

A systematic review of experimental studies on Salmonella persistence in insects

Pinarelli Fazion,

Marzoli,

Pezzuto

et al. 2023

npj Sci Food

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The consumption of insects as food and feed has been recently suggested as a possible alternative to the rising global food need, thus it is crucial to monitor any potential food safety hazards in the insect supply chain. The aims of this systematic review were to collect, select, and evaluate studies investigating the persistence of Salmonella in insects. We searched PUBMED, EMBASE, WEB of Science Core Collection, and Food Science and Technology Abstracts. In total, 36 papers investigating the persistence of Salmonella in insects (both holometabolous and heterometabolous) were included after screening. Regarding complete metamorphosis insects, the longest Salmonella persistence was reported in Phormia regina, in which the pathogen persisted for 29 days at 5 °C. Similarly, Salmonella persisted in the feces of Alphitobius diaperinus for 28 days. The incomplete metamorphosis insect showing the longest Salmonella persistence (>10 months) was Blatella germanica. Periplaneta americana excreted Salmonella via feces for 44 days until all the insects were dead. The retrieved data on the persistence of Salmonella can be useful for further analysis by risk assessors and decision-makers involved in the safety of insect-based food, contributing to defining the sanitary requirements and risk mitigation measures along the supply chain. The review protocol is registered in PROSPERO database (CRD42022329213).

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Bombyx mori from a food safety perspective: A systematic review

Cited by 19 publications

References 81 publications

Effects of Chromium Exposure on the Gene Expression of the Midgut in Silkworms, Bombyx mori

Effects of Chromium Exposure on the Gene Expression of the Midgut in Silkworms, Bombyx mori

Purification, Immunological Identification, and Characterization of the Novel Silkworm Pupae Allergen Bombyx mori Lipoprotein 3 (Bomb m 6)

A systematic review of experimental studies on Salmonella persistence in insects

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