Bombyx mori Nucleopolyhedrovirus Hijacks Multivesicular Body as an Alternative Envelopment Platform for Budded Virus Egress

Abstract

BmNPV is a severe pathogen that infects mainly Bombyx mori , a domesticated insect of economic importance, and accounts for approximately 15% of economic losses in sericulture. BV production plays a key role in systemic BmNPV infection of larvae.

Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS

“… 49 In Bombyx mori nucleopolyhedrovirus mature virions, the membrane fusion protein GP64 is secreted into the plasma membrane, retaining its signal peptide, which is required for infection. 50 , 51 , 52 Here, we found that the signal peptides containing BIg-like domains performed the cell membrane-binding function and were not cleaved. The cleavage efficiency was related to the length of the signal peptides; when the C terminus of the signal peptide was more prolonged than nine residues, the cleavage efficiency decreased, and no cleavage was observed when the C terminus was 13 residues long.…”