BoMiProt: A database of bovine milk proteins

Maity, Sudipa; Bhat, Aadil Hussain; Giri, Kuldeep; Ambatipudi, Kiran

doi:10.1016/j.jprot.2020.103648

Cited by 31 publications

(26 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also serve as some of the main nutrients in the diet of infants and young children, such as cheese and yogurt. 41,53,56,66 Based on the recent studies using mass spectrometry, it has been proven that milk is a source of over 3100 different proteins, but only some of them have allergenic potential 67 ; of these proteins, 80% are casein and 20% whey proteins. 68 The percentage composition of clinically significant proteins constituting CMP is shown in Figure 2.…”

Section: Casein Proteinsmentioning

confidence: 99%

The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy

Popielarz

Krogulska

2021

aei

View full text Add to dashboard Cite

Cow’s milk allergy (CMA) is an increasingly common problem among children and adults that requires the use of appropriate diagnostics to eliminate allergic reactions and prevent unnec-essary dietary regimes. The current diagnostics methods are imperfect hence new, more effective methods are still being sought. Component-resolved diagnostics (CRD) is one of them. CRD assesses sensitivity to individual allergen molecules using purified native or recombinant allergens. The present paper reviews the role of CRD in diagnosing CMA, as well as the benefits and limitations of its use, especially in predicting allergy development or acquiring immunotolerance. It examines the possibility of replacing the current gold diagnostic standard with component tests directed against specific milk proteins. In addition, CRD could be helpful in the evaluation of prognosis. However, CRD allows for improvement in clinical management, particularly of polysensitized subjects, there is still no cogent evidence that it offers more efficient CMA diagnostics than existing tests.

show abstract

Section: Casein Proteinsmentioning

confidence: 99%

The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy

Popielarz

Krogulska

2021

aei

View full text Add to dashboard Cite

show abstract

“…Milk and its derivatives constitute one of the fundamental components of the human diet, particularly due to its protein and mineral contributions (P senkov a et al, 2020); although it is also of interest due to the diversity of proteins, fats, carbohydrates and bioactive substances they contain (Maity et al, 2020). Therefore, its contamination, among other compounds, by heavy metals, can represent a serious public health problem due to different disorders that these cause to consumers, particularly in children (Nava-Ruíz and M endez-Armenta, 2011; CDC (Centers for Disease Control and Prevention), 2012; Tepanosyan et al, 2017;Ngo et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Heavy metals in blood, milk and cow's urine reared in irrigated areas with wastewater

Pompilio

Francisco

Tulio

et al. 2021

Heliyon

View full text Add to dashboard Cite

The aim of this work was to determine the content of lead (Pb), chromium (Cr), cadmium (Cd), arsenic (As), copper (Cu), strontium (Sr) and thallio (Tl) in blood, milk and urine from cows fed forage irrigated with sewage water and cultivated in the vicinity of the Popocat epetl volcano and determine the rate of transfer of these elements from blood to milk and urine. Digestion was performed in a microwave oven (CEM-MarsX). The determination was made using an ICP -OES. The Cd in the blood was significantly higher than in milk and urine. The Cr in the blood was higher than in the urine. In milk the content of Pb and Cu was significantly higher than in blood. Sr and Tl concentration in the urine was higher than that detected in milk and blood and Pb in blood. Milk transfer Index revealed a significant difference in relation to the TI values found in the urine and only in the case of Cu in milk was TI > 1. In urine, the values found of Sr and Tl were higher than milk TI. It is concluded that when metals are ingested by cows in fodder, they are easily transferred to milk and urine through the blood. Presence of heavy metals in the different matrices determines the degree of environmental and trofic chain contamination with which we can consider the cow a biomarker.

show abstract

“…However, comparative proteomic analysis across different lactation stages was conducted in Malnad Gidda cattle (19) and Jersey and Kashmiri cattle (34). A recent report compiled an online database with 3,100 proteins from milk whey, milk fat globular membrane, and exosomes (35). Similarly, another separate study reported 4,654 cow milk proteins in five lactation stages to create the database.…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Mass Spectrometer–Based Ultra-Deep Profile of Milk Whey Proteome in Indian Zebu (Sahiwal) Cattle

Chopra¹,

Ali²,

Bathla³

et al. 2020

Front. Nutr.

View full text Add to dashboard Cite

Milk serves as a mode of protection to neonate through transferring the host defense proteins from mother to offspring. It also guards the mammary gland against various types of infections. Along with the presence of six vital proteins, bovine milk (whey) contains a massive class of minor proteins, not all of which have been comprehensively reported. In this study, we performed an LC-MS/MS-based ultra-deep identification of the milk whey proteome of Indian zebu (Sahiwal) cattle. Three independent search engines that are Comet, Tandem, and Mascot-based analysis resulted in the discovery of over 6,210 non-redundant proteins commonly identified. Genome-wise mapping revealed that chromosome 1 showed a minimum expression of 14 proteins, whereas chromosome 19 expressed 250 maximum proteins in milk whey. These results demonstrate that milk proteome in Sahiwal cattle is quite complicated, and minor milk fractions play a significant role in host defense.

show abstract

BoMiProt: A database of bovine milk proteins

Cited by 31 publications

References 36 publications

The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy

The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy

Heavy metals in blood, milk and cow's urine reared in irrigated areas with wastewater

High-Resolution Mass Spectrometer–Based Ultra-Deep Profile of Milk Whey Proteome in Indian Zebu (Sahiwal) Cattle

Contact Info

Product

Resources

About