Bonding of a Silorane‐Based Composite System to Bone

Wu, Xiaohong; Watts, David C.

doi:10.1002/adem.200900127

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Although initially developed for use in dentistry, silorane-based cements have been recognized for their potential applications in orthopaedics. 13 , 14 We have developed a silorane-based biomaterial (SBB) intended for use as an orthopaedic cement, suitable for weight-bearing applications, local delivery of antibiotics, grafting for bone lesions, voids or defects, and augmentation of various implants. 15 Unlike the silorane-based dental cements, which require ultraviolet (UV) light for polymerization, this SBB uses a dual-cure initiation system composed of both a light photoinitiation and chemical catalysts.…”

Section: Introductionmentioning

confidence: 99%

Elution of rifampin and vancomycin from a weight-bearing silorane-based bone cement

Funk

Menuey

Ensminger

et al. 2021

Bone & Joint Research

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Aims Poly(methyl methacrylate) (PMMA)-based bone cements are the industry standard in orthopaedics. PMMA cement has inherent disadvantages, which has led to the development and evaluation of a novel silorane-based biomaterial (SBB) for use as an orthopaedic cement. In this study we test both elution and mechanical properties of both PMMA and SBB, with and without antibiotic loading. Methods For each cement (PMMA or SBB), three formulations were prepared (rifampin-added, vancomycin-added, and control) and made into pellets (6 mm × 12 mm) for testing. Antibiotic elution into phosphate-buffered saline was measured over 14 days. Compressive strength and modulus of all cement pellets were tested over 14 days. Results The SBB cement was able to deliver rifampin over 14 days, while PMMA was unable to do so. SBB released more vancomycin overall than did PMMA. The mechanical properties of PMMA were significantly reduced upon rifampin incorporation, while there was no effect to the SBB cement. Vancomycin incorporation had no effect on the strength of either cement. Conclusion SBB was found to be superior in terms of rifampin and vancomycin elution. Additionally, the incorporation of these antibiotics into SBB did not reduce the strength of the resultant SBB cement composite whereas rifampin substantially attenuates the strength of PMMA. Thus, SBB emerges as a potential weight-bearing alternative to PMMA for the local delivery of antibiotics. Cite this article: Bone Joint Res 2021;10(4):277–284.

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Section: Introductionmentioning

confidence: 99%

Elution of rifampin and vancomycin from a weight-bearing silorane-based bone cement

Funk

Menuey

Ensminger

et al. 2021

Bone & Joint Research

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“…[16][17][18][19][20] It was also shown that a silorane-based dental composite can effectively bond to bone. 21 In order to begin to develop better bone cements, we analyzed the effect of silorane-based resins on bone cell function in vitro and in vivo. One aim of the present study was to analyze the effect of silorane-based resin on bone cell proliferation, differentiation, and mineralization.…”

Section: Introductionmentioning

confidence: 99%

Silorane resin supports proliferation, differentiation, and mineralization of MLO‐A5 bone cells in vitro and bone formation in vivo

et al. 2012

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Methyl methacrylate used in bone cements has drawbacks of toxicity, high exotherm, and considerable shrinkage. A new resin, based on silorane/oxirane chemistry, has been shown to have little toxicity, low exotherm, and low shrinkage. We hypothesized that silorane-based resins may also be useful as components of bone cements as well as other bone applications and began testing on bone cell function in vitro and in vivo. MLO-A5, late osteoblast cells, were exposed to polymerized silorane (SilMix) resin (and a standard polymerized bisGMA/TEGDMA methacrylate (BT) resin and compared to culture wells without resins as control. A significant cytotoxic effect was observed with the BT resin resulting in no cell growth, whereas in contrast, SilMix resin had no toxic effects on MLO-A5 cell proliferation, differentiation, nor mineralization. The cells cultured with SilMix produced increasing amounts of alkaline phosphatase (1.8-fold) compared to control cultures. Compared to control cultures, an actual enhancement of mineralization was observed in the silorane resin-containing cultures at days 10 and 11 as determined by von Kossa (1.8–2.0 fold increase) and Alizarin red staining (1.8-fold increase). A normal bone calcium/phosphate atomic ratio was observed by elemental analysis along with normal collagen formation. When used in vivo to stabilize osteotomies, no inflammatory response was observed, and the bone continued to heal. In conclusion, the silorane resin, SilMix, was shown to not only be non cytototoxic, but actually supported bone cell function. Therefore, this resin has significant potential for the development of a nontoxic bone cement or bone stabilizer.

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“…It can also delineate local effects from systemic factors (Meghji et al, 1998). We previously developed a critical size defect (CSD) organ culture model (Wu and Watts, ).…”

Section: Introductionmentioning

confidence: 99%

Mouse calvarial defect Model: An approach for the micro‐tomographic evaluation of polymer scaffolds

Wang

Deng

et al. 2014

Microscopy Res & Technique

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The ability of bone repair scaffolds to form bone is traditionally evaluated using cell culture and animal experiments. Mouse calvarial organ culture maintains the natural cell-to-cell and cell-to-matrix relationships as well as the anatomical order, and this model has been used to study the biological behavior of intramembranous bones. The aim of this study was to evaluate the potential of mouse calvarial organ culture to be used as an in vitro model to study the bone regenerative ability of bone repair polymer scaffolds. Critical size defects (CSD) were created in the parietal bones. Electrospun poly(ε-caprolactone) scaffolds were placed into one group of defects. The remaining defects served as a control. The bones were cultured for 38 days and analyzed with μCT, phase-contrast microscopy, dissecting microscopy, scanning electron microscopy, and energy-dispersive X-ray analyses. This organ culture technique is easily available and could permit researchers to quickly establish a valuable database of candidate bone repair scaffolds.

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Bonding of a Silorane‐Based Composite System to Bone

Cited by 7 publications

References 16 publications

Elution of rifampin and vancomycin from a weight-bearing silorane-based bone cement

Elution of rifampin and vancomycin from a weight-bearing silorane-based bone cement

Silorane resin supports proliferation, differentiation, and mineralization of MLO‐A5 bone cells in vitro and bone formation in vivo

Mouse calvarial defect Model: An approach for the micro‐tomographic evaluation of polymer scaffolds

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