This study tested the impact of different adhesives and resin composite cements on shear bond strength (SBS) to polymethyl methacrylate (PMMA)-and composite-based CAD/CAM materials. SBS specimens were fabricated and divided into five main groups (n=30/group) subject to conditioning: 1. Monobond Plus/Heliobond (MH), 2. Visio.link (VL), 3. Ambarino P60 (AM), 4. exp. VP connect (VP), and 5. no conditioning-control group (CG). All cemented specimens using a. Clearfil SA Cement and b. Variolink II were stored in distilled water for 24 h at 37°C. Additionally, one half of the specimens were thermocycled for 5,000 cycles (5°C/55°C, dwell time 20 s). SBS was measured; data were analyzed using descriptive statistics, four-and one-way ANOVA, unpaired two-sample t-test and Chi 2 -test. CAD/CAM materials without additional adhesives showed no bond to resin composite cements. Highest SBS showed VL with Variolink II on composite-based material, before and after thermocycling.