Bone Absorption and the Immune System

Nisbet, N. W.

doi:10.1111/j.1365-3083.1981.tb00601.x

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…The immune system may be involved in the regulation of bone formation and resorption (Nisbet 1981). Several reports have suggested that the removal or the absence of the thymus gland alters the growth and metabolism of bone (Berek et al 1968, Mandi et al 1971, Campbell et al 1979, Gyarmati et al 1983.…”

Section: Bone Metabolism and Repair Are Normal In Athymic Ratsmentioning

confidence: 99%

Bone metabolism and repair are normal in athymic rats

Kirkeby

1991

Acta Orthopaedica Scandinavica

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Several reports indicate that the thymus gland is important in the regulation of bone metabolism. Anatomic or physiologic abnormalities in the bones of athymic animals could therefore be expected. The mechanical properties, circulation, and mineralization rate of intact femora, tibiae, ossa ilia, and of an osteotomized tibia of athymic Lewis rats were compared with those of normal Lewis rats. The results were not significantly different in the two groups. The absence of the thymus thus does not seem to have any major influence on bone structure, function, or regenerative properties.

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Section: Bone Metabolism and Repair Are Normal In Athymic Ratsmentioning

confidence: 99%

Bone metabolism and repair are normal in athymic rats

Kirkeby

1991

Acta Orthopaedica Scandinavica

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Qualitative defects in natural killer cell function in ia osteopetrotic rats

Schneider

Relfson

Ellis

1992

Journal of Bone and Mineral Research

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Recent studies have provided evidence that cells of the immune system and their associated cytokines function in the regulation of bone turnover. The incisors absent (ia) osteopetrotic rat represents a model in which a defect in the immune system and bone resorption can be studied. Osteopetrosis in the ia rat is characterized by a generalized excess accumulation of bone as a result of reduced bone resorption by defective osteoclasts that lack a ruffled border and the ability to exocytose their osteolytic enzymes. Previous attempts to identify associated defects in the ia immune system have proven unsuccessful; ia rats demonstrate normal delayed hypersensitivity, mitogenic activity, and macrophage function. Inasmuch as the skeletal manifestations of the ia mutation may be the result of a defect in exocytosis, related defects may be evident in immune cells utilizing exocytosis of granules or enzymes for their cytolytic function. Natural killer (NK) cells function by such a mechanism. Therefore, these studies were undertaken to evaluate the natural immune system in ia rats. NK activity assessed by 51Cr release assays was significantly reduced in ia animals compared to normal littermates. Mononuclear cells isolated from the peripheral blood of ia rats revealed a significantly greater percentage of large granular lymphocytes than normal littermates. Comparison of NK cell phenotypes using two phenotypic parameters for NK cells (OX8+, OX19- cells and 3.2.3+ cells) revealed that the mononuclear isolates of spleen and peripheral blood of mutant animals had significantly greater percentages of OX8+, OX19- and 3.2.3+ cells than normal controls.(ABSTRACT TRUNCATED AT 250 WORDS)

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Cyclosporin A does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat

et al. 1994

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The weanling rat, an animal model of rapid bone turnover, was used to evaluate the effects of various doses of cyclosporin A (CsA) on various bones during different time periods. Sprague-Dawley male rats were extensively prelabeled with 3H-tetracycline during 1-3 weeks of age. At 4 weeks of age, four groups of rats were given daily subcutaneous injections: vehicle or CsA--low dose (10 mg/kg), intermediary dose (20 mg/kg), or high dose (30 mg/kg) for 7, 14, or 28 days. Three different whole bones--the femur (low turnover), scapula (moderate turnover), and lumbar-6 vertebra (high turnover) were harvested intact at 4, 5, 6, and 8 weeks of age. The whole bones were assayed weekly for total dry defatted weight, calcium mass (formation), and loss of 3H-tetracycline (bone resorption) following treatment with CsA. Serum CsA levels, calcium creatinine, and alkaline phosphatase were measured weekly. Significant decreases in serum calcium and alkaline phosphatase were observed at 1 and 2 weeks, and were normalized by 4 weeks of treatment. No significant changes in serum creatinine were noted. For all three doses of CsA, no effect was observed on the absolute rate of cortical bone resorption of three different, whole bones over three time periods. Body weight and bone formation in treated animals was significantly smaller in a dose- and time-related fashion compared with control animals at sacrifice. However, compared with the initial control animals, body weights and bone masses of the final treated animals were much larger, suggesting that the smaller bone masses were due to insufficient growth and slow gain in bone mass.(ABSTRACT TRUNCATED AT 250 WORDS)

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Bone Absorption and the Immune System

Cited by 8 publications

References 23 publications

Bone metabolism and repair are normal in athymic rats

Bone metabolism and repair are normal in athymic rats

Qualitative defects in natural killer cell function in ia osteopetrotic rats

Cyclosporin A does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat

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