Bone allografts pretreated with a bisphosphonate are not resorbed

Aspenberg, Per; Åstrand, Jörgen

doi:10.1080/000164702317281350

Cited by 75 publications

(64 citation statements)

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“…Animal studies suggest pretreatment of bone allografts with bisphosphonates may be an effective therapeutic strategy for inhibiting osteoclastic resorption [1,13,22].…”

Section: Discussionmentioning

confidence: 99%

“…bisphosphonate methydiphosphonate and implanted into host rats experienced less resorption than scapulae harvested from untreated donor rats [22]. A subsequent rat study using donor cancellous bone allografts treated in vitro with alendronate and implanted into host rats determined the allografts were not resorbed and became infiltrated with the host rat's bone [1]. However, a canine study using morselized allografts treated with alendronate determined that while osteoclastic resorption of the morsels was inhibited, their incorporation into host bone was also inhibited and new bone formation in regions adjacent to the morsels was blocked [13].…”

Section: Discussionmentioning

confidence: 99%

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Bisphosphonate Delivery to Tubular Bone Allografts

DiResta

Manoso

Naqvi

et al. 2008

Clin Orthop Relat Res

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Large structural allografts used for reconstruction of bone defects after revision arthroplasty and tumor resection fracture up to 27% of the time from osteolytic resorption around the fixation screw holes and tendon or ligament attachment sites. Treating structural allografts before implantation with bisphosphonates may inhibit local osteoclastic processes and prevent bone resorption and the development of stress risers, thereby reducing the long-term fracture rate. Taking advantage of allografts' open-pore structure, we asked whether passive soaking or positive-pressure pumping was a more efficient technique for delivering bisphosphonates. We treated matched pairs of ovine tibial allografts with fluids containing Tc-99m pamidronate and toluidine blue stain to facilitate indicator distribution analysis via microSPECT-microCT imaging and light microscopy, respectively. Surfactants octylphenoxy polyethoxy ethanol or beractant were added to the treatment fluids to reduce flow resistance of solutions pumped through the allografts. Indicator distribution after 1 hour of soaking produced a thin ring around periosteal and endosteal surfaces, while pumping for 10 minutes produced a more even distribution throughout the allograft. Flow resistance was reduced with octylphenoxy polyethoxy ethanol but unaffected with beractant. Pumped allografts displayed a more homogeneous indicator distribution in less time than soaking while surfactants enhanced fluid movement.

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“…Animal studies suggest pretreatment of bone allografts with bisphosphonates may be an effective therapeutic strategy for inhibiting osteoclastic resorption [1,13,22].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bisphosphonate Delivery to Tubular Bone Allografts

DiResta

Manoso

Naqvi

et al. 2008

Clin Orthop Relat Res

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show abstract

“…By treating the bone allograft with a bisphosphonate, both the amount of remaining graft after remodeling and the amount of new bone can be increased (Aspenberg and Åstrand 2002). Therefore, the mechanical strength of the graft probably improves.…”

mentioning

confidence: 97%

A combination of bisphosphonate and BMP additives in impacted bone allografts

Jeppsson

Åstrand

Tägil

et al. 2003

Acta Orthopaedica Scandinavica

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“…The treatment may reduce allograft resorption and reduce the risk of mechanical implant failure. Several studies have indicated that bisphosphonate-treated bone allograft is not as readily resorbed as untreated bone allograft [6][7][8][9][10][11][12][13] . However, despite preservation of the allograft, not all studies indicated a positive effect on mechanical implant fixation 11,12 .…”

mentioning

confidence: 99%