Bone alterations in hepatitis C virus infected patients

Serum sclerostin in hepatitis C virus infected patients

“…[27] However, a paradoxical positive correlation was observed between BMD and sclerostin As commented earlier, sclerostin antagonizes Wnt/β-catenin signaling, [3] and decreases bone turn-over [4,5] and bone mass, [6,7] but several authors report results similar to those obtained in this study: a positive correlation between sclerostin and BMD, instead of a negative one. This is the case of Cejka et al [12] in renal patients, Polyzos et al [13] and Sheng et al [8] in postmenopausal women, or García-Martín et al [10] in diabetic patients, among other authors.…”

“…In fact, some studies including relatively large series fail to detect significant bone alterations in HCV patients. [26,27] Moreover, osteosclerosis has been described in several cases of chronic HCV infection. [28][29][30] Based on the aforementioned statements, it is important to explore which is the role of serum sclerostin on bone alterations observed in HCV patients, and which is the relation of sclerostin and osteocalcin with fat-derived cytokines involved in insulin resistance and with one of the consequences of insulin resistance, such as liver fat accumulation.…”

Osteoporosis in Chronic Hepatitis C Virus with Advanced Liver Fibrosis

“…These results are in accordance with our results, that showed a correlation between osteoporosis and the advanced affection of the liver. In contrast Pelazas-González et al [19] did not find correlation between bone variables and liver fibrosis. This may be because most of their studied patients had mild fibrosis.…”

“…Therefore, we added smoking as a cofactor in logistic regression and proved that advanced fibrosis associated with abnormal BMD in a univariate analysis. On the contrary Pelazas-González et al [19] did not find a significant associations between either BMD and smoking nor with fibrosis. One limitation of this study was the amount difference between both groups (early or no fibrosis and advanced fibrosis) this was because of the randomization regarding the stage of fibrosis.…”

Czynność osi GH/IGF-I, stężenie hormonów kalciotropowych we krwi oraz gęstość mineralna kości u młodych osób z przewlekłym wirusowym zapaleniem wątroby

“…We believe that this is due to the decreased severity of hepatic impairment presented by our patients. Pelazas-Gonzalez et al [36] observed that chronic HCV infection in well-nourished patients with preserved liver function does not cause osteoporosis. The selection of our study group, excluding cholestasis, helped us to eliminate the influence of abnormal intestinal absorption of calcium caused by bile obstruction [37] and cholestasis itself, which is considered to be an independent risk factor for osteoporosis [38].…”