Bone and mineral metabolism in older adults with Parkinson's disease

Abou‐Raya, S.; Helmii, M.; Abou‐Raya, A.

doi:10.1093/ageing/afp137

Cited by 99 publications

(69 citation statements)

References 26 publications

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“…Our study showed that 7.4-23.4% of the patients had osteoporosis and 38.3-49.3% had osteopenia. These findings are largely consistent with those of previous studies [8,9,27,28]. The median Z-scores for bone loss in our study were close to zero.…”

Section: Discussionsupporting

confidence: 93%

The Association of Musculoskeletal Pain with Bone Mineral Density in Patients with Parkinson's Disease

Choi

Kim²,

Jung³

et al. 2017

Eur Neurol

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Background: Pain and osteoporosis are common in Parkinson's disease (PD), and lower bone mineral density (BMD) or osteoporosis may be associated with an increased risk of reporting to have pain in the general population. The aim of this study was to determine whether there is an association between the pain subtypes and the BMD in patients with PD. Methods: We included 162 PD patients. Pain was assessed using the patients' descriptions, a structured interview, a detailed neurologic examination, and the Visual Analogue Scale. BMD was measured using dual energy X-ray absorptiometry scans. Results: Of the 162 PD patients, 120 had chronic pain, while 42 reported no pain. The most prevalent type of pain was musculoskeletal, followed by radicular/neuropathic, dystonic, and central. PD patients with musculoskeletal pain had a lower BMD than PD patients without pain. Multivariate regression analysis showed that the low BMD of the lumbar spine, hip, and femoral neck were related to old age, female gender, low MBI, and the presence of musculoskeletal pain. Conclusion: PD patients with musculoskeletal pain have low BMD and are at risk for developing osteoporosis. If a PD patient has musculoskeletal pain and other risk factors related to low BMD, clinicians should consider screening for osteoporosis.

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Section: Discussionsupporting

confidence: 93%

The Association of Musculoskeletal Pain with Bone Mineral Density in Patients with Parkinson's Disease

Choi

Kim²,

Jung³

et al. 2017

Eur Neurol

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“…There is evidence of low-levels of vitamin D, and increased bone turnover markers, such as bone alkaline phosphatase compared to controls [261]. Being that all the non-genomic role of vitamin D above described, patients [264].…”

Section: Vitamin D Deficiency and Neurodegenerative Diseasesmentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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“…The anosmia group shows more serious gait disturbance than the hyposmia and normosmia groups in this study. Gait disturbance and freezing of gait are very important issues in PD because they are directly related to injury [18], loss of mobility [19], admission to nursing homes [20] and ultimately increased mortality. It is worthy of notice that this study demonstrates the associations among gait, olfaction, and the central cholinergic system in the early stage of PD.…”

Section: Discussionmentioning

confidence: 99%

Gait Disturbance Associated with Cholinergic Dysfunction in Early Parkinson's Disease

Lim¹,

Ham²,

Lee³

et al. 2017

J Alzheimers Dis Parkinsonism

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Bone and mineral metabolism in older adults with Parkinson's disease

Abstract: PD is associated with an increased incidence of osteoporosis, falls and fractures. PD is thus a risk factor for osteoporosis and appropriate therapeutic interventions should be initiated to slow or prevent disability.

Cited by 99 publications

References 26 publications

The Association of Musculoskeletal Pain with Bone Mineral Density in Patients with Parkinson's Disease

The Association of Musculoskeletal Pain with Bone Mineral Density in Patients with Parkinson's Disease

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Gait Disturbance Associated with Cholinergic Dysfunction in Early Parkinson's Disease

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