Bone and skeletal muscle changes in oldest-old women: the role of physical inactivity

Cavedon, Valentina; Milanese, Chiara; Laginestra, Fabio Giuseppe; Giuriato, Gaia; Pedrinolla, Anna; Ruzzante, Federico; Schena, Federico; Venturelli, Massimo

doi:10.1007/s40520-019-01352-x

Cited by 15 publications

(17 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite previous research linking sedentism and bone resorption (Cavedon et al, 2020; LeBrasseur & Westendorf, 2017), the direct relationship between sedentary activity and BMD was less clear in the NHANES, 2007–2010 sample. The adoption of life course perspectives by bioarcheologists has significantly contributed to our understanding of bone morphology and how it is impacted by biocultural histories, particularly subsistence strategies and activity.…”

Section: Discussionmentioning

confidence: 66%

Pathways linking activity, adiposity, and inflammation to bone mineral density in women and men from NHANES 2007 to 2010

Griffin

Dent

Berger

2021

American J Hum Biol

View full text Add to dashboard Cite

Objectives Age, sedentary activity, central adiposity, and inflammation have all been independently associated with bone mineral density (BMD). We assessed how the effects of sedentary activity and central adiposity on BMD of the lumbar spine and femoral neck change across early to late adulthood and whether these relationships are mediated by inflammation. Methods We analyzed data from 7135 women and men 20 years of age and older from NHANES 2007 to 2010. Anthropometrics, sedentary activity (min/day), serum CRP (mg/dl), and BMD (gm/cm2 measured by DXA scans) at the femoral neck and lumbar spine. Data were compared by age and sex groups and through causal mediation analysis. Results The effect of waist circumference on BMD was significantly mediated by serum CRP at both skeletal sites in men and at the femoral neck in women. Sedentary activity did not have a direct relationship to BMD but was mediated by waist circumference in men. Least square means differed significantly by sex and age groups with a general age‐related decline in BMD at both skeletal sites. Conclusions We found that central adiposity, independent of overall body size and composition as measured through BMI, has an inverse relationship with BMD that is mediated by serum CRP. In addition, the negative impact of increased sedentism acted through changes in central adiposity (waist circumference) but only in men. Although low bone density and osteoporosis are often considered degenerative diseases that primarily impact postmenopausal women, our findings show that sedentary activity and central adiposity impact bone density beginning in early adulthood in both women and men.

show abstract

Section: Discussionmentioning

confidence: 66%

Pathways linking activity, adiposity, and inflammation to bone mineral density in women and men from NHANES 2007 to 2010

Griffin

Dent

Berger

2021

American J Hum Biol

View full text Add to dashboard Cite

show abstract

“…Osteoporosis disease may progress silently until a fracture occurs or kyphosis presents. Osteoporotic patients can lose up to 4 inches in body height and also may suffer severe chronic pain as a result of the bending or collapse of the spine [ 49 ]. However, the correlations between body height and TGF-β1 or IL-10 gene polymorphisms in osteoporotic development have not yet been revealed.…”

Section: Discussionmentioning

confidence: 99%

Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients

Han

Lan

et al. 2021

Genes

View full text Add to dashboard Cite

Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.

show abstract

“…25 These people would inevitably be relying on wheelchair to assist their daily living. 26 Wheelchairbound elderlies usually have limited physical activity and are therefore associated with lower BMD 27 and ability to control body position, and thus have an increased risk of fall and osteoporotic fractures. A study from Grant Medical Center in the USA investigated 30 wheelchairbound participants who fell from wheelchair over a 5-year period.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of low-magnitude high-frequency vibration (LMHFV) on musculoskeletal health of participants on wheelchair: a study protocol for a single-blinded randomised controlled study

Chow

Wong

et al. 2020

BMJ Open

View full text Add to dashboard Cite

BackgroundOsteoporosis is an age-related disease with progressive loss of bone, leading to fragile bone. It is one of the major health issues in older adults and causes medical, social and economic impacts globally. Patients with osteoporosis have high risk of osteoporotic fractures. Low-magnitude high-frequency vibration (LMHFV) is a non-invasive biophysical intervention providing whole-body mechanical stimulation. Previous studies showed that LMHFV is beneficial to muscle strength, postural control, balancing ability, new bone formation, spinal bone mineral density (BMD) and blood circulation. During the LMHFV treatment, older adults need to stand upright on the platform for 20 min/day. However, some physically weak elderlies with poor musculoskeletal ability cannot stand for a long period. Therefore, the design of vibration platform is modified for the disabled patients to treat at sitting position and the efficacy of LMHFV on this group of elderlies will be verified. It is hypothesised that new design of LMHFV is beneficial to wheelchair users in terms of vertebral BMD, muscle health and musculoskeletal functions.MethodsThis study is a single-blinded randomised controlled trial to investigate the effect of LMHFV on vertebral BMD, muscle health, balancing ability and functional ability in wheelchair users (mainly on wheelchair for outdoor activities). Healthy elderlies aged 65 years or above with walking difficulties and using wheelchair are eligible. Exclusion criteria are those: (1) who cannot stand and walk independently, (2) who have vibration treatment before, (3) with malignancy, (4) with acute fractures or severe osteoarthritis, (5) with cardiovascular concern such as with pacemaker in situ, (6) with chronic inflammatory conditions known to affect muscle metabolism such as rheumatoid arthritis and (7) with high frequency of physical activities, such as participants who participated in regular exercise five times a week or more. Recruited participants will be randomised to either LMHFV or control group. Participant assigned to LMHFV group will receive LMHFV (35 Hz, 0.3g (g=gravitational acceleration), 20 min/day, at least three times/week) for 6 months. The primary outcome is BMD at the lumbar spine to be assessed by dual-energy X-ray absorptiometry that is clinically recommended for the diagnosis of osteoporosis. All primary and secondary outcome assessments for all groups will be performed in the investigators’ institute at baseline and 6 months post treatment.DiscussionThis study aims to investigate the effects of LMHFV on wheelchair users. The findings of this study will help to confirm the efficacy of LMHFV on vertebral BMD, muscle health, balancing ability and functional outcomes in wheelchair using elderlies. LMHFV therapy is an intervention strategy that is easy to implement at the community healthcare level or individually at home that has previously been proven to reduce fall risk and muscle strength at the lower limb. The ultimate goal is to improve their bone and muscle quality of wheelchair users, as well as enhancing their quality of life.Trial registration numberClinicalTrials.gov (NCT04180267).

show abstract

Bone and skeletal muscle changes in oldest-old women: the role of physical inactivity

Cited by 15 publications

References 49 publications

Pathways linking activity, adiposity, and inflammation to bone mineral density in women and men from NHANES 2007 to 2010

Pathways linking activity, adiposity, and inflammation to bone mineral density in women and men from NHANES 2007 to 2010

Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients

Efficacy of low-magnitude high-frequency vibration (LMHFV) on musculoskeletal health of participants on wheelchair: a study protocol for a single-blinded randomised controlled study

Contact Info

Product

Resources

About