Bone Augmented With Allograft Onlays for Implant Placement Could Be Comparable With Native Bone

Al‐Abedalla, Khadijeh; Torres, Juan Ramón Fernández; Cortes, Arthur Rodríguez González; Wu, Xing; Nader, Samer Abi; Daniel, Nach G.; Tamimi, Faleh

doi:10.1016/j.joms.2015.06.151

Cited by 27 publications

(28 citation statements)

References 58 publications

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“…[13][14][15] Nevertheless, controversial results have been reported in the literature. While some authors reported encouraging results, [16][17][18] other studies described questionable data regarding to its resorption and long-term sequestration of the graft. [19][20][21][22][23] However, factors underlying bone graft resorption remain unclear, since they can be influenced by different variables as embryologic origin, characteristics of recipient site in terms of vascularization, mechanical stress and graft's microarchitecture.…”

Section: Resultsmentioning

confidence: 99%

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Clinical and radiographic outcomes of allogeneic block grafts for maxillary lateral ridge augmentation: A randomized clinical trial

Tresguerres

Cortes

Vallejo

et al. 2019

Clin Implant Dent Rel Res

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Background A main drawback of bone block graft surgery is the resorption occurring in early stages of healing. To our knowledge, there are no studies comparing outcomes of freeze‐dried bone allograft (FDBA) blocks with different architecture. Purpose The aim of this work was to investigate different factors that can affect graft resorption and to compare the resorption rates of two different types of allogeneic blocks, corticocancellous and cancellous. Materials and Methods A randomized clinical trial was designed. Twenty‐eight patients referred for onlay bone augmentation prior to implant placement were included in the study. Preoperative computerized tomography (CT) was taken for all patients. Patients received FDBA blocks of either cancellous or corticocancellous bone obtained from the iliac crest. After a 4‐month follow‐up, postoperative CT was taken. Then, another surgery was performed, with the purpose to place dental implants. The aforementioned groups were compared for bone resorption and implant outcome using analysis of covariance (ANCOVA) and repeated ANOVA measures, respectively. Demographic data, trabecular bone density, and graft sites were also analyzed. Results A total of 93 implants were placed in the augmented bone sites over 28 patients. A 100% survival rate was achieved during a mean follow‐up period of 24 months in both groups. Higher bone resorption rate was found with cancellous bone grafts (29.2% ± 2.6) compared with corticocancellous grafts (19.3% ± 2.3). Moreover, higher resorption rates in patients with lower bone density (<185 Hounsfield Units) (31.7% ± 3.1) and smokers (26.39% ± 2.3) were observed when compared with patients with higher bone density (>185 Hounsfield Units) (16.8% ± 2.1) and nonsmokers (22.1% ± 2.3), respectively. Conclusion Within the limitations of this study, these findings indicate that both corticocancellous and cancellous FDBA grafts constitute a clinical acceptable alternative for bone reconstruction, although cancellous grafts present higher resorption rates. Moreover, host factors such as patient's low bone density and smoking habits may also increase graft resorption rates.

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Section: Resultsmentioning

confidence: 99%

“…Nevertheless, controversial results have been reported in the literature. While some authors reported encouraging results, other studies described questionable data regarding to its resorption and long‐term sequestration of the graft …”

Section: Introductionmentioning

confidence: 99%

Clinical and radiographic outcomes of allogeneic block grafts for maxillary lateral ridge augmentation: A randomized clinical trial

Tresguerres

Cortes

Vallejo

et al. 2019

Clin Implant Dent Rel Res

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“…This has resulted from the broad set of indications in which allografts function predictably and analogous to the surgical techniques established for autografts. Allogenic bone grafts also have an excellent safety profile, as a World Health Organization initiated study demonstrated no reports on transmission of any kind of infectious diseases associated with freeze‐dried bone allografts (FDBA) . Furthermore, the increasing demand for implant‐borne prosthesis is concordant with rising numbers of bone augmentation procedures, as these are often required to provide sufficient bone quantity prior to or with installation of a dental implant …”

Section: Discussionmentioning

confidence: 99%

“…Allogenic bone grafts also have an excellent safety profile, as a World Health Organization initiated study demonstrated no reports on transmission of any kind of infectious diseases associated with freeze-dried bone allografts (FDBA). [24][25][26][27][28] Furthermore, the increasing demand for implant-borne prosthesis is concordant with rising numbers of bone augmentation procedures, as these are often required to provide sufficient bone quantity prior to or with installation of a dental implant. 5,6 Clinical data on the survival and success rates of allogenic bone blocks are excellent, ranging from 93.7% to 100%, however, allogenic bone blocks were reported to be more technique-sensitive and susceptible to infection when compared to autografts.…”

Section: Discussionmentioning

confidence: 99%

Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report

Blume

Donkiewicz

Back

et al. 2019

J Esthet Restor Dent

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Objective Various biomaterials have been successfully applied in alveolar bone regeneration, however, the reconstruction of extensive osseous defects remains challenging and is often unfeasible with granular grafting materials. Several studies have outlined allogenic bone blocks as valid alternative to autologous block grafting. Clinical Considerations In this report, we demonstrate the regeneration of two large osseous defects in the maxilla with allogenic bone blocks made from human donor bone. The bone blocks were customized using the CAD/CAM technology in order to enable the insertion of four dental implants. Conclusions Both blocks perfectly matched the defect geometry, showed limited resorption, led to the formation of sufficient amounts of mineralized bone in both horizontal and vertical dimensions and enabled the installation of implants according to the treatment plan. The implementation of innovative technologies for individualization of allogenic bone blocks simplifies the restoration of complex and extensive osseous defects and poses great benefits for both practitioners and patients. Clinical Significance The here presented procedure demonstrates the successful regeneration of two extensive osseous defects in a patient suffering from hypodontia using two CAD/CAM manufactured allogenic bone blocks, rendering the procedure far less invasive as compared to guided bone regeneration carried out with autologous transplants. Furthermore, to the best of our knowledge, this is the first case report that radiographically demonstrates the new formation of a cortical bone layer following block grafting with solely cancellous bone blocks.

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“…53,54 We found that this material was able to accelerate bone healing and osseointegration. This type of biomaterial 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 (cell-and factor-free) is of great interest in bone regeneration because it allows more realistic translation to clinical application 31,55 Computerized micro-tomography (µ-CT) scans were performed on bone samples that were retrieved at different time points 3, 7 and 14 days after surgery for NMP treated and nontreated defects. At day 3, there was no visible difference on the µ-CT scans between the control and NMP group.…”

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confidence: 99%

Two-Dimensional Magnesium Phosphate Nanosheets Form Highly Thixotropic Gels That Up-Regulate Bone Formation

Laurenti¹,

Subaie

Abdallah³

et al. 2016

Nano Lett.

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Hydrogels composed of two-dimensional (2D) nanomaterials have become an important alternative to replace traditional inorganic scaffolds for tissue engineering. Here, we describe a novel nanocrystalline material with 2D morphology that was synthesized by tuning the crystallization of the sodium-magnesium-phosphate system. We discovered that the sodium ion can regulate the precipitation of magnesium phosphate by interacting with the crystal's surface causing a preferential crystal growth that results in 2D morphology. The 2D nanomaterial gave rise to a physical hydrogel that presented extreme thixotropy, injectability, biocompatibility, bioresorption, and long-term stability. The nanocrystalline material was characterized in vitro and in vivo and we discovered that it presented unique biological properties. Magnesium phosphate nanosheets accelerated bone healing and osseointegration by enhancing collagen formation, osteoblasts differentiation, and osteoclasts proliferation through up-regulation of COL1A1, RunX2, ALP, OCN, and OPN. In summary, the 2D magnesium phosphate nanosheets could bring a paradigm shift in the field of minimally invasive orthopedic and craniofacial interventions because it is the only material available that can be injected through high gauge needles into bone defects in order to accelerate bone healing and osseointegration.

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Bone Augmented With Allograft Onlays for Implant Placement Could Be Comparable With Native Bone

Cited by 27 publications

References 58 publications

Clinical and radiographic outcomes of allogeneic block grafts for maxillary lateral ridge augmentation: A randomized clinical trial

Clinical and radiographic outcomes of allogeneic block grafts for maxillary lateral ridge augmentation: A randomized clinical trial

Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report

Two-Dimensional Magnesium Phosphate Nanosheets Form Highly Thixotropic Gels That Up-Regulate Bone Formation

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