Bone bonding strength of calcium phosphate ceramic coated strain gauges

Battraw, G. Aaron; Szivek, John A.; Anderson, P.

doi:10.1002/(sici)1097-4636(1999)48:1<32::aid-jbm7>3.3.co;2-o

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endothelial cells have been noted to have a similar dependence on surface topographies as was noted in studies that looked at pore size and spacing, 29 as well as surface roughness. 30 The results of this experiment are consistent with previous experiments 28 showing inhibited osteoblast growth on relatively rougher surfaces. However, the increased MVEC proliferation noted on CPC surfaces in this study conflicts with a previous study demonstrating endothelial cells preferred smooth surfaces, 30 since the CPC particle coatings have much more surface roughness than the control and epoxy coated wells where MVEC proliferation was inhibited to a greater extent.…”

Section: Discussionsupporting

confidence: 90%

“…The proliferation of MVECs on CPC surfaces and the maintenance of their phenotype 29 may explain why CPC-coated implants cultured with MVECs have previously demonstrated rapid bone attachment following in vivo placement. 21 Taking into consideration previous studies 30 in which implants coated with CPC 7 encouraged rapid and secure bone attachment (showing bond strengths of 4.8 MPa in 6 weeks), this study supports the use of CPC 7 if MVECs are to be grown on the CPC surface in culture for placement in a bone bed in vivo.…”

Section: Discussionsupporting

confidence: 73%

See 1 more Smart Citation

Selective cell proliferation can be controlled with CPC particle coatings

Szivek

Margolis

Schnepp

et al. 2007

J Biomedical Materials Res

View full text Add to dashboard Cite

To develop implantable, engineered, cartilage constructs supported by a scaffold, techniques to encourage rapid tissue growth into, and on the scaffold are essential. Preliminary studies indicated that human endothelial cells proliferated at different rates on different calcium phosphate ceramic (CPC) particles. Judicious selection of particles may encourage specific cell proliferation, leading to an ordered growth of tissues for angiogenesis, osteogenesis, and chondrogenesis. The goal of this study was to identify CPC surfaces that encourage bone and vascular cell growth, and other surfaces that support chondrocyte growth while inhibiting proliferation of vascular cells. Differences in bone and vascular cell proliferation were observed when using epoxy without embedded CPCs to encourage bone cells, and when three CPCs were tested, which encouraged vascular cell proliferation. One of these (CPC 7) also substantially depressed cartilage cell proliferation. Only one small-diameter crystalline CPC (CPC 2) supported rapid chondrocyte proliferation, and maintained the cartilage cell phenotype.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 73%

Selective cell proliferation can be controlled with CPC particle coatings

Szivek

Margolis

Schnepp

et al. 2007

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…This strain gauge configuration produced accurate linear elastic load strain measurements during bench top testing over a range of angles that encompass those observed during normal gait 18,20 and demonstrated consistent results during a pilot in vivo study. 10 The gauges were waterproofed with Master Bond (Master Bond, Hackensack, NJ), 21 coated with a blend of calcium phosphate ceramic (CPC) particles that encourage rapid bone bonding, 22 and calibrated using a published procedure 9 described in the next section. The transmitter was waterproofed using medical grade silicone (Sylgard, Midland, MI).…”

Section: Scaffold Strain Gauge and Transmitter Preparationmentioning

confidence: 99%

Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time

et al. 2007

Self Cite

View full text Add to dashboard Cite

Polymer scaffolds have been used as a tool to provide growth and integration of engineered tissue substrates to repair damaged tissues in many organ systems including articular cartilage. Previous work has shown that "sensate" scaffolds, with integrated strain gauges have the potential for use as both a delivery vehicle for engineered cartilage as well as a device that can measure real time, in vivo joint loading. The purpose of this study was to use an implanted subminiature telemetry system to collect in vivo joint loading measurements over an extended period following placement of a "sensate" scaffold. Measurements were collected from seven of nine sensors that were implanted into the stifles of three canines. The limb loading rates and load distribution through gait were dependent on stride time but did not vary with time post op. The peak loads were not dependent on stride time but significantly increased with time post op. This demonstrated that peak loading measured with "sensate" scaffolds can be used to monitor healing. The portability of the "sensate" scaffolds coupled to telemetry systems highlights the potential use of this system in a clinical research setting to gather important information to improve tissue engineering and rehabilitation regimens.

show abstract

“…A second layer of dissolved polysulfone was applied and blended calcium phosphate ceramic (CPC) particles were attached using a published procedure. 33 The blend, which consisted of hydroxyapatite and tricalcium phosphate particles, has previously been noted to encourage rapid bone growth 34 and anchor scaffolds securely within the condyle. 31 Stem cell harvesting and scaffold implanation NIH guidelines were followed for the care and use of test animals (8th Edition, NRC, National Academies Press, Washington DC, 2010).…”

Section: Scaffold Preparation For In Vivo Implantationmentioning

confidence: 99%

Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee

et al. 2016

Self Cite

View full text Add to dashboard Cite

Two complete unicondylar surface replacement scaffold designs to support tissue-engineered cartilage growth that utilized adult endogenous stem cells were 3D printed and tested in a dog stifle model. Integrated rosette strain gauges were calibrated and used to determine shear loading within stifle joints for up to 12 months. An activity index that compared extent of daily activity with tissue formation showed differences in the extent and quality of new tissue with the most active animal having the most new tissue formation. Shear loads were highest early and decreased with time indicating that cartilage tissue formation begins while tissues experience high shear loads and continues as the loads decrease toward normal physiological levels. Scaffolds with biomimetic support pegs facilitated the most rapid bone ingrowth and were noted to have more cartilage formation with better quality cartilage as measured using both indentation testing and histology. Comparison of implant placement depth to previous studies suggested that placement depth affects the amount of tissue formation. This study provides measurements of loading patterns and cartilage regeneration on a complete medial condylar surface replacement that can be used for preclinical testing of a tissue engineering approach for the most common form of early stage osteoarthritis, unicondylar disease. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1409-1421, 2017.

show abstract

Bone bonding strength of calcium phosphate ceramic coated strain gauges

Cited by 3 publications

References 0 publications

Selective cell proliferation can be controlled with CPC particle coatings

Selective cell proliferation can be controlled with CPC particle coatings

Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time

Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee

Contact Info

Product

Resources

About