Bone cell biology: The regulation of development, structure, and function in the skeleton

Marks, Sandy C.; Popoff, Steven N.

doi:10.1002/aja.1001830102

Cited by 412 publications

(218 citation statements)

References 479 publications

(435 reference statements)

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“…1, pathway 3). Additional support for a microenvironmental modulation of the osteogenic lineage phenotypes to either cartilage or bone has been documented by Kantomaa and Hall (1988), and reviewed by Marks and Popoff (1988).…”

Section: Discussionmentioning

confidence: 97%

Chondrogenic potential of chick embryonic calvaria: I. Low calcium permits cartilage differentiation

Jacenko

Tuan

1995

Developmental Dynamics

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Calvaria from day-14 calciumdeficient chick embryos produced by long-term maintenance in shell-less culture, exhibit a cartilage-like phenotype (Jacenko and Tuan 119861 Dev. Biol. 11521L232), which is restored to an osteogenic phenotype upon calcium repletion to the embryo. The expression of cartilage markers in a typically osteogenic tissue under calcium deficiency implies the presence of chondrogenic cells, and questions the conditions associated with calcium deficiency which may cause their divergent pathway of differentiation. In the present study, by explanting normal and shell-less embryonic calvarial pairs in organ culture in vitro and experimentally regulating their calcium supply, the calcium status of the calvaria was modulated as a function of medium calcium. Histological and immunoblotting analyses demonstrated for the first time that calvaria possess cells which can form genuine cartilage. This chondrogenic potential is expressed only in a low-calcium environment, where cartilage forms in both normal and shellless calvarial pairs; their calcium-suplemented counterparts, however, develop as fully osteogenic tissues. Furthermore, chondrogenesis in both normal and shell-less calvaria indicates that the chondrogenic cells must be endogenous constituents of the calvaria, rather than being derived elsewhere in response to systemic calcium deficiency. Finally, the correlation between matrix under-calcification and cartilage expression in the embryonic calvarium suggests that calcium, perhaps in the form of matrix mineral, may modulate cell differentiation during skeletogenesis.

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Section: Discussionmentioning

confidence: 97%

Chondrogenic potential of chick embryonic calvaria: I. Low calcium permits cartilage differentiation

Jacenko

Tuan

1995

Developmental Dynamics

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“…Bone repair depends on migration, proliferation and differentiation of osteogenic cells into osteoblastic ones (Marks and Popoff, 1988) and this process can be altered by some patients' life habits such as alcoholism (Lima et al, 2011), tabagism (Bueno et al, 2011 and coffee consumption (Tsuang et al, 2006;Lacerda et al, 2010). The present study shows that cigarette smoke inhalation and coffee consumption interfered substantially negatively on the bone formation and osseous integration of the DHA implant in the CC group.…”

Section: Discussionmentioning

confidence: 99%

Effects of cigarette smoke inhalation and coffee consumption on bone formation and osseous integration of hydroxyapatite implant

et al. 2013

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The present study aims to assess the effects of cigarette smoke inhalation and/or coffee consumption on bone formation and osseous integration of a dense hydroxyapatite (DHA) implant in rats. For this study, 20 male rats were divided into four groups (n = 5): CT (control) group, CE (coffee) group, CI (cigarette) group and CC (coffee + cigarette) group. During 16 weeks, animals in the CI group were exposed to cigarette smoke inhalation equivalent to 6 cigarettes per day; specimens in the CE group drank coffee as liquid diet; and rats in the CC group were submitted to both substances. In the 6 th week a 5 mm slit in the parietal bone and a 4 mm slit in the tibia were performed on the left side: the former was left open while the latter received a DHA implant. As soon as surgeries were finished, the animals returned to their original protocols and after 10 weeks of exposure they were euthanised (ethically sacrificed) and the mentioned bones collected for histological processing. Data showed that exposure to cigarette smoke inhalation and coffee consumption did not interfere in weight gain and that solid and liquid diet consumption was satisfactory. Rats in the CC group showed a decrease in bone neoformation around the tibial DHA implant (31.8 ± 2.8) as well as in bone formation in the parietal slit (28.6 ± 2.2). On their own, cigarette smoke inhalation or coffee consumption also led to diminished bone neoformation around the implant and delayed the bone repair process in relation to the CT group. However, reduction in the bone repair process was accentuated with exposure to both cigarette smoke inhalation and coffee consumption in this study.Keywords: cigarette, bone, hydroxyapatite, bone formation, coffee.Os efeitos do cigarro e do consumo de café sobre a formação óssea e a integração óssea de implantes de hidroxiapatita ResumoO presente estudo teve como objetivo avaliar os efeitos do tabagismo e do consumo de café, isolada ou concomitantemente, sobre a formação óssea e a osseointegração de implantes hidroxiapatita densa. Foram utilizados 20 ratos machos, divididos em quatro grupos (n = 5): grupo CT (controle); grupo CA (café); grupo CI (cigarro), e grupo CC (cigarro + café). Durante 16 semanas, os animais do grupo CI foram expostos à fumaça de seis cigarros/dia; os animais do grupo CA consumiram café como dieta líquida, e os animais do grupo CC, ambas as substâncias. Após seis semanas de exposição, uma falha óssea de 5 mm foi produzida no osso parietal esquerdo e de 4 mm, na tíbia esquerda dos animais. A falha do parietal foi mantida aberta, enquanto na tíbia corpos cerâmicos de hidroxiapatita densa (HAD) foram implantados em cavidade produzida cirurgicamente. Após as cirurgias, os animais retornaram aos protocolos experimentais e, ao término de dez semanas, foram eutanasiados, sendo as tíbias e os parietais coletados para processamento histológico. A exposição à fumaça do cigarro e o consumo de café não interferiram no ganho de peso dos animais, e os consumos de dieta líquida e sólida foram satisfatórios...

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“…12,14) Normally, osteoblasts derive from precursor cells in the perivascular connective tissue, the cambium layer of the periosteum, and the bone marrow. 3,4) In particular, bone morphogenetic protein (BMP) is a strong trigger capable of inducing osteoblasts even from non-osteoprogenic cells.…”

Section: Discussion I Bone Histologymentioning

confidence: 99%

In Vivo Histological Changes Occurring in Hydroxyapatite Cranial Reconstruction. Case Report.

Okii

Nishimura²,

Kurisu

et al. 2001

Neurol. Med. Chir.(Tokyo)

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Histological changes were observed in a hydroxyapatite plate and hydroxyapatite granules used to repair a craniotomy defect and removed after 2 years and 9 months of use. The hydroxyapatite plates and granules had completely fused to the cranium, with new bone formation on the dural side extending in a three-dimensional matrix along the pores with the Haversian system in the center. New bone formation was less extensive under the artificial dura than under the normal dura. This finding suggests that the dura has the ability to promote bone formation. A new vessel was found along the interconnecting pores. The interconnecting pores allow osteoconduction in the hydroxyapatite plate, so new bone formation can progress. Hydroxyapatite has osteoconduction properties and is biocompatible, so gains strength in vivo through new bone formation, and is the ideal material for artificial bones. Factors important to achieving good bone formation after cranial reconstruction surgery include presence of the dura, and pore size approximate to the Haversian system (100-500 mm) and interconnecting pores in the hydroxyapatite plate.

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Bone cell biology: The regulation of development, structure, and function in the skeleton

Cited by 412 publications

References 479 publications

Chondrogenic potential of chick embryonic calvaria: I. Low calcium permits cartilage differentiation

Chondrogenic potential of chick embryonic calvaria: I. Low calcium permits cartilage differentiation

Effects of cigarette smoke inhalation and coffee consumption on bone formation and osseous integration of hydroxyapatite implant

In Vivo Histological Changes Occurring in Hydroxyapatite Cranial Reconstruction. Case Report.

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