Bone changes associated with oral retinoid theraphy

White, S.I.; Mackie, RonaM.

doi:10.1016/0163-7258(89)90080-6

Cited by 26 publications

(8 citation statements)

References 36 publications

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“…Thus, in the past decade similar effects were observed after retinoid therapy [1], It is gener ally agreed that bone toxicity includes premature epiphys ial closure in children, spurring along the anterior margins of spines (often mimicking a diffuse idiopathic skeletal hyperostosis), periostitis, ossification of ligamentous inser tions and osteoporosis [2][3][4][5], So far, mainly the effects of isotretinoin (13-cis-retinoic acid) and etretinate (Ro 10-9359) have been studied. Results from studies at the National Institutes of Health (Bethesda, Md., USA) indi cate that etretinate treatment induces predominantly peripheral, extraspinal tendon and ligament calcification, whereas isotretinoin therapy has been associated with a high rate of spinal ligament calcification [6], Little is known about skeletal changes after acitretin (Ro 10-1670) treatment.…”

Section: Introductionsupporting

confidence: 49%

A Prospective Study of Skeletal Changes during Short-Term Acitretin Therapy

Hohl

Pelloni²,

Sigg³

et al. 1992

Dermatology

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We prospectively analyzed skeletal changes of 16 patients who were treated with acitretin for various disorders of keratinization at doses of 10–50 mg/day (overall mean 0.4 mg/kg/day) for 7–12 months (mean 11.4 months). Skeletal changes from pretherapy findings were observed in 5 patients. In 4 of 5 patients they appeared to be linked to a preexisting degenerative pathology and could not be attributed to acitretin therapy. However, in 1 patient a spinal osseous side effect could not be excluded. No retinoid-induced extraspinal tendon or ligament calcifications were observed.

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Section: Introductionsupporting

confidence: 49%

A Prospective Study of Skeletal Changes during Short-Term Acitretin Therapy

Hohl

Pelloni²,

Sigg³

et al. 1992

Dermatology

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“…Small bony projections or spurs develop along the anterior margin of the vertebral body of the thoracic vertebra. Cervical and lumbar vertebral bodies may also be affected in this way (White & McKie 1989). Etretinate, isotretinoin and acitretin have been associated with the DISH syndrome (diffuse interstitial skeletal hyperostosis) [Kilcoyne 1988].…”

Section: Musculoskeletal Effectsmentioning

confidence: 99%

Adverse Reactions to Oral Retinoids An Update

Mills

Marks

1993

Drug Safety

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Retinoids, both naturally occurring and synthetic, are analogues of vitamin A. They represent a major advance in the treatment of acne and psoriasis, as well as rarer conditions such as the ichthyoses. The more frequent and widespread use of these drugs requires that the dermatologist be aware of the wide spectrum of adverse events that may be encountered with their use. Some are serious and irreversible, such as teratogenicity, necessitating great care if these drugs are given to women of childbearing potential. Other effects may be less severe, dose dependent and reversible. Although not devastating to the patient, appropriate advice may reduce morbidity.

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“…20 They include pain, diffuse idiopathic skeletal hyperostosis, 21 premature closure of epiphyses, 22,23 and calcification of ligaments and tendons at bony insertions. 24,25 "Lucent" bones have been described 24,26 on radiographs, and a spontaneous vertebral fracture developed in 1 person receiving isotretinoin long term.…”

mentioning

confidence: 99%