Bone conducted responses in the neonatal rat auditory cortex

Makarov, Roman; Sintsov, Mikhail; Valeeva, Guzel; Starikov, Pavel; Negrov, D. A.; Khazipov, Roustem

doi:10.1038/s41598-021-96188-9

Cited by 9 publications

(7 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the first two postnatal weeks, when the eyes and ears of rodents are still closed and they perform no active whisking, coordinated activity patterns in the sensory periphery occur mainly independently of sensory input [1,2]. Even if strong auditory and visual stimuli can evoke activity in the corresponding primary sensory cortices before eye and ear opening [3][4][5][6] and sensory feedback evoked by twitches during active sleep promotes cascades of neuronal activity in the primary somatosensory cortex [7], prominent activity patterns in the developing primary sensory cortices are largely driven by spontaneous neuronal discharges in the immature peripheral sensory structures [8]. Both spontaneous and stimulus-driven activity trigger discontinuous oscillatory bursts in the corresponding primary sensory cortices [5,[9][10][11][12] that are necessary for the development of sensory discrimination [13].…”

Section: Introductionmentioning

confidence: 99%

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development

Kostka

Hanganu‐Opatz

2021

Preprint

View full text Add to dashboard Cite

Cognitive processing relies on the functional refinement of the limbic circuitry during the first two weeks of life. During this developmental period, when most sensory systems are still immature, the sense of olfaction acts as 'door to the world', providing the main source of environmental inputs. However, it is unknown whether early olfactory processing shapes the development of the limbic circuitry. Here, we address this question by combining simultaneous in vivo recordings from the olfactory bulb (OB), lateral entorhinal cortex (LEC), hippocampus (HP), and prefrontal cortex (PFC) with opto- and chemogenetic manipulations of mitral/tufted cells (M/TCs) in the OB of non-anesthetized neonatal mice. We show that the neonatal OB synchronizes the limbic circuity in beta frequency range. Moreover, it drives neuronal and network activity in LEC, as well as subsequently, HP and PFC via long-range projections from mitral cells (MCs) to HP-projecting LEC neurons. Thus, OB activity controls the communications within limbic circuits during neonatal development.

show abstract

Section: Introductionmentioning

confidence: 99%

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development

Kostka

Hanganu‐Opatz

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The development of biodentine expanded the indications of calcium silicate cement such as endodontic procedures involving dentin and cementum repair, pulp regeneration, management of external root resorption, base beneath a resin composite, and also as intermediate restoration [ 7 ]. Recently, many adhesive dental restorative materials were believed to interact passively with the enamel/dentin they were placed on, depending on the infiltration of the material [ 8 ]. Materials that express a particular biological reaction at the interface between the material and tissue, resulting in the establishment of a bond, are considered bioactive materials.…”

Section: Discussionmentioning

confidence: 99%

Titanium- and Strontium-Infused Calcium Silicates Toward Restorative and Regenerative Purposes

Patel,

Joshy

et al. 2024

Cureus

View full text Add to dashboard Cite

Background: Dental materials with dentine regenerative properties are preferred over conventional materials. Calcium silicate cements, such as Biodentine, are bioactive and offer excellent sealing ability, making them ideal for various dental treatments. Objectives: This study aimed to fabricate bioactive calcium silicates infused with titanium (Ti) and strontium (Sr) to optimize their neo-angiogenic, antimicrobial, and regenerative properties while maintaining mechanical stability. Methodology: Ti- and Sr-infused calcium silicate cements were synthesized, and their mineral phases were characterized using X-ray diffraction. Morphological and elemental analyses were performed using field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDS). Raman spectroscopy was used to confirm the formation of bioactive material. A hemocompatibility assessment was conducted to evaluate blood compatibility. Results: The presence of Ca 2 , SiO 4 , and SrTiO 3 mineral phases indicated the successful infusion of Ti and Sr into the calcium silicate cement. FESEM and EDS revealed interconnected small spheres and rods in the silicate network with the relevant elemental compositions. Raman spectra verified that Si-O-Si and Ti-O-Ti vibrations exist, validating the formation of a bioactive material. The hemocompatibility assessment demonstrated optimal blood compatibility. Conclusions: This study successfully fabricated an improved calcium silicate-based material with enhanced regenerative properties and excellent biocompatibility. This newly formed substrate holds promise for providing superior restorative solutions and aiding in conservative treatment modalities during dental procedures.

show abstract

“…In the three areas, synchronized spontaneous activity is present during the first postnatal week, but it desynchronizes through the second postnatal week in A1 (Babola et al, 2018 ; Meng et al, 2020 ); V1 (Rochefort et al, 2009 ; Ackman et al, 2012 ; Siegel et al, 2012 ), and S1 (Golshani et al, 2009 ; Che et al, 2018 ). In A1 (top panel), the onset of evoked sensory activity takes place by the end of the first postnatal week and it becomes more prominent upon ear opening at P11 (Anthwal and Thompson, 2016 ; Makarov et al, 2021 ). Two auditory critical periods for pure tones (PT CP; Barkat et al, 2011 ) and Frequency modulated sweeps (FMS CP; Bhumika et al, 2020 ) take place shortly after, P12–15 and P31–38 respectively.…”

Section: Development Of Neuronal Activity and Cortical Microcircuits ...mentioning

confidence: 99%

“…Hearing onset in mice occurs around P11, upon ear canal opening (Anthwal and Thompson, 2016 ). However, high-intensity, bone-conducted acoustic stimuli can evoke cortical responses in A1 as early as P8 (Makarov et al, 2021 ). While the subcortical connectivity is already present at this stage, cortical connectivity is still undeveloped and progressively matures in response to the acoustic sensory environment.…”

Section: Development Of Neuronal Activity and Cortical Microcircuits ...mentioning

confidence: 99%

The Role of Inhibitory Interneurons in Circuit Assembly and Refinement Across Sensory Cortices

Ferrer

García

2022

Front. Neural Circuits

View full text Add to dashboard Cite

Sensory information is transduced into electrical signals in the periphery by specialized sensory organs, which relay this information to the thalamus and subsequently to cortical primary sensory areas. In the cortex, microcircuits constituted by interconnected pyramidal cells and inhibitory interneurons, distributed throughout the cortical column, form the basic processing units of sensory information underlying sensation. In the mouse, these circuits mature shortly after birth. In the first postnatal week cortical activity is characterized by highly synchronized spontaneous activity. While by the second postnatal week, spontaneous activity desynchronizes and sensory influx increases drastically upon eye opening, as well as with the onset of hearing and active whisking. This influx of sensory stimuli is fundamental for the maturation of functional properties and connectivity in neurons allocated to sensory cortices. In the subsequent developmental period, spanning the first five postnatal weeks, sensory circuits are malleable in response to sensory stimulation in the so-called critical periods. During these critical periods, which vary in timing and duration across sensory areas, perturbations in sensory experience can alter cortical connectivity, leading to long-lasting modifications in sensory processing. The recent advent of intersectional genetics, in vivo calcium imaging and single cell transcriptomics has aided the identification of circuit components in emergent networks. Multiple studies in recent years have sought a better understanding of how genetically-defined neuronal subtypes regulate circuit plasticity and maturation during development. In this review, we discuss the current literature focused on postnatal development and critical periods in the primary auditory (A1), visual (V1), and somatosensory (S1) cortices. We compare the developmental trajectory among the three sensory areas with a particular emphasis on interneuron function and the role of inhibitory circuits in cortical development and function.

show abstract

Bone conducted responses in the neonatal rat auditory cortex

Cited by 9 publications

References 72 publications

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development

Titanium- and Strontium-Infused Calcium Silicates Toward Restorative and Regenerative Purposes

The Role of Inhibitory Interneurons in Circuit Assembly and Refinement Across Sensory Cortices

Contact Info

Product

Resources

About