Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials

Abstract

Addition of bioactive materials such as Titanium oxide (TiO2), and incorporation of bio inert ceramic such as alumina (Al2O3), into polyetheretherketone (PEEK) has been adopted as an effective approach to improve bone-implant interfaces. In this paper, hot pressing technique has been adopted as a production method. This technique gave a homogenous distribution of the additive materials in the proposed composite biomaterial. Different compositions and compounding temperatures have been applied to all samples. Mechanical properties and animal model have been studied in all different production conditions. The results of these new TiO2/Al2O3/PEEK biocomposites with different compositions were promising, mechanical properties within the range of human cortical bone, suitable for load bearing applications. At the same time, in vivo test shows no inflammation reaction with implanted samples. Sustained viability in contact with the sample over seven-day period, showed evidence of excellent biocompatibility in injured rejoins.

Assessment of Sheep Omentum for Soft-tissue Engineering Scaffolds

“…Engineering methods for skeletal muscle tissue regeneration hold promise for treating muscle diseases like muscle dystrophy, traumatic injury, and aggressive tumor ablation. Degradable biomaterials induce new tissue and cell ingrowth, or serve as temporary scaffolds [4][5][6]. The study uses patient's cells or immunologically inactive allogenic or xenogenic cells to engineer tissue scaffolds, potentially replacing lost tissue function and offering new therapeutic options for skin damage in burns.…”

The Influence of Strontium Oxide on the Physio-Mechanical Properties of Biomedical-Grade Titanium in Ti-SrO Composites

“…Numerous studies have shown that modifying surfaces with inorganic metal elements such as zinc (Zn), magnesium (Mg), and strontium (Sr) can hasten osseointegration and encourage the formation of new bones [10]. As a result, ceramic oxides or metallic dispersions are used as reinforcing agents [11]. Sr is thought to have multiple action mechanisms.…”