Bone deficits in children and youth with type 1 diabetes: A systematic review and meta-analysis

Zheng, Yuwen; Abadi, Mahdi Rostami Haji; Ghafouri, Zahra; Góes, Suelen Meira; Johnston, James D.; Nour, Munier; Kontulainen, Saija

doi:10.1016/j.bone.2022.116509

Cited by 11 publications

(4 citation statements)

References 57 publications

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“…This expansion would enhance the reliability and generalizability of the research conclusions. (2) In this study, the evaluation using Micro-CT and histopathology was limited to the lumbar spine of diabetic rabbits after confirming an increase in bone marrow fat through imaging.…”

Section: Limitation Analysismentioning

confidence: 96%

“…Recent evidence suggests that impaired skeletal health is closely related to an increase in bone marrow fat content and altered bone marrow fat composition. Additionally, diabetes can lead to an imbalance in the ratio between bone marrow fatty acids and unsaturated fatty acids [2]. Marrow fat is believed to play roles in lipid storage, skeletal remodeling, metabolic homeostasis, and mechanical function [4].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of bone marrow fat content and fatty acid composition using quantitative MRI combined with metabonomics in alloxan-induced diabetic rabbits

Zhang,

Hu,

Fei

et al. 2024

Preprint

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Purpose The objective of this study was to evaluate the bone marrow of alloxan-induced diabetic rabbits through the application of iterative decomposition of water and fat with echo asymmetry and least squares estimated quantitative sequence (IDEAL-IQ), micro computed tomography (Micro-CT), and gas chromatography-mass spectrometry (GC-MS). Methods Twenty male Japanese white rabbits were randomly assigned to two groups: the diabetic group (n=10) and the control group (n=10).The lumbar vertebral bone marrow fat content of the rabbits was evaluated using the IDEAL-IQ quantification sequence at four-week intervals following the induction of diabetes. Upon the identification of statistically significant differences in the lumbar bone marrow fat fraction (FF) between the diabetic and control groups, the experimental rabbits were euthanized following ethical guidelines.Subsequently, lumbar spine samples were collected for further analysis, including Micro-CT examination, histopathological examination, and GC-MS analysis. Results In the 16th week, a statistically significant difference in vertebral marrow fat fraction (FF) was observed between the diabetes group and the control group. Micro-CT and histopathological examinations revealed a significant reduction in trabecular bone density and an increased presence of adipocytes in the diabetic group compared to the control group. The OPLS-DA model successfully distinguished between the control group and the diabetic group, identifying nine specific fatty acids that were most strongly associated with the observed differences. Conclusion In a diabetic rabbit osteoporosis model, there are alterations in the bone marrow fat content and fatty acid composition.

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Section: Limitation Analysismentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Evaluation of bone marrow fat content and fatty acid composition using quantitative MRI combined with metabonomics in alloxan-induced diabetic rabbits

Zhang,

Hu,

Fei

et al. 2024

Preprint

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“…Studies highlight changes that occur with growth and maturation, including substantial gains in bone geometry, density, and strength, as well as increases in trabecular and cortical thickness and decreases in cortical porosity at the distal tibia and radius [ 1 – 4 ]. In pediatric clinical populations, such as children with type 1 diabetes, altered bone microarchitecture may help explain increased fracture risk [ 5 , 6 ]. As imaging devices such as HR-pQCT become more commonly used, we are acquiring a better understanding of the hierarchical structure of bone [ 7 ] and the subtle adaptations in bone structure and microarchitecture that underpin changes in bone strength across the lifespan.…”

Section: Introductionmentioning

confidence: 99%

Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations

Gabel

Kent

Hosseinitabatabaei

et al. 2023

Curr Osteoporos Rep

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Purpose of Review The purpose of this review is to summarize current approaches and provide recommendations for imaging bone in pediatric populations using high-resolution peripheral quantitative computed tomography (HR-pQCT). Recent Findings Imaging the growing skeleton is challenging and HR-pQCT protocols are not standardized across centers. Adopting a single-imaging protocol for all studies is unrealistic; thus, we present three established protocols for HR-pQCT imaging in children and adolescents and share advantages and disadvantages of each. Limiting protocol variation will enhance the uniformity of results and increase our ability to compare study results between different research groups. We outline special cases along with tips and tricks for acquiring and processing scans to minimize motion artifacts and account for growing bone. Summary The recommendations in this review are intended to help researchers perform HR-pQCT imaging in pediatric populations and extend our collective knowledge of bone structure, architecture, and strength during the growing years.

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“…Among the detrimental complications of the disease is osteoporosis, even in the lower ages. Children and youth with T1D were found to have lower bone mineral content (BMC), lower areal bone density (aBMD) and deficits in trabecular bone density and micro-architecture [2]. These deficits, along with microvascular complications, are probably responsible for the observed increased fracture risk across the life span of T1D patients [3].…”

Section: Introductionmentioning

confidence: 99%

Higher Adiponectin Levels in Children and Adolescents with T1D Probably Contribute to the Osteopenic Phenotype through the RANKL/OPG System Activation

Tsentidis,

Gourgiotis,

Kossiva

et al. 2023

Endocrines

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Background: Diabetes mellitus is an increasing global health emergency, with serious complications (including osteoporosis). Leptin and adiponectin are among the least-investigated possible contributing factors of T1D low bone mass. Methods: In this case-control cross-sectional analysis, we evaluated 40 pairs of T1D children and adolescents and controls. We evaluated body diameters and skinfolds, leptin, adiponectin, lipids and lipoproteins, bone metabolic markers and DXA parameters of BMD and fat percentage. Results: Leptin levels were comparable between groups and correlated well with body mass parameters. Adiponectin levels were found to be higher in the patient group and correlated with higher levels of HbA1c, triglycerides and s-RANKL. Conclusions: In this study, leptin levels were no different, but adiponectin levels were found to be higher in children and adolescents with T1D and correlated with diabetic metabolic derangement indices and s-RANKL in the patient group. Adiponectin can be considered a surrogate marker of T1D in young patients’ metabolic status and probably contributes to the diabetic low bone mass phenotype via activation of the RANKL/OPG metabolic pathway.

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Bone deficits in children and youth with type 1 diabetes: A systematic review and meta-analysis

Cited by 11 publications

References 57 publications

Evaluation of bone marrow fat content and fatty acid composition using quantitative MRI combined with metabonomics in alloxan-induced diabetic rabbits

Evaluation of bone marrow fat content and fatty acid composition using quantitative MRI combined with metabonomics in alloxan-induced diabetic rabbits

Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations

Higher Adiponectin Levels in Children and Adolescents with T1D Probably Contribute to the Osteopenic Phenotype through the RANKL/OPG System Activation

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