Bone Density Loss Is Associated With Blood Cell Counts

Valderrábano, Rodrigo J.; Lui, Li‐Yung; Lee, Jennifer; Cummings, Steven R.; Orwoll, Eric S.; Hoffman, Andrew R.; Wu, Joy Y.

doi:10.1002/jbmr.3000

Cited by 57 publications

(63 citation statements)

References 41 publications

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“…The current study is consistent with our previous report that bone loss over a mean 6.9 years was associated with anemia in older men, but cross-sectional bone density by DXA was not 11 . In an Italian cohort, anemia was found to be correlated with low BMD by pQCT in cross-section 12 .…”

Section: Discussionsupporting

confidence: 93%

“…Evidence regarding an association between WBCs and BMD in humans is lacking. Other than our prior study in older men 11 one small study in postmenopausal women with osteoporosis, determined by DXA, had decreased numbers of B lymphocytes compared to those without 15 . These findings support the notion that a broader relationship between hematopoiesis and bone health can be observed in humans through blood count parameters and bone density testing.…”

Section: Introductioncontrasting

confidence: 59%

“…We found that a higher WBC count was associated with increased lumbar spine BMD in women but otherwise WBC count or change in WBC count over time was not observed to be associated with BMD in men and women. Our previous evaluation of older men revealed that poor bone health was related to different WBC subtypes in opposing directions, as hip bone loss was associated with both high neutrophils and low lymphocytes 11 . In a cross sectional study of 50 post-menopausal women, those with osteoporosis (DXA BMD T-score under −2.5) had decreased B lymphocytes compared to those with normal bone density 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Data on the impact of altered blood counts on bone phenotypes in relatively healthy adults is less abundant. We recently demonstrated in a prospective observational study that older men with greater hip bone loss have an increased risk of anemia, low lymphocytes and high neutrophils 11 . These findings parallel changes in RBCs and white blood cells (WBCs) observed in certain animal models of bone disease 3,6–8 .…”

Section: Introductionmentioning

confidence: 99%

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Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study

Valderrábano

Bůžková

Chang

et al. 2019

Bone

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Purpose: Osteoblasts and their precursors support hematopoiesis in the bone marrow. We hypothesized that declines in Hgb levels are associated with bone mineral density (BMD). Methods: The Cardiovascular Health Study is a prospective longitudinal study that enrolled 5,888 community-dwelling adults aged >65 years and measured hemoglobin twice, in 1989–90 and 1992–93, as well as BMD by dual-energy X-ray absorptiometry (DXA) in 1994–95. In a subset of 1,513 men and women with a Hgb in 1992–93 and BMD, we used linear regression to estimate associations of Hgb (per standard deviation (SD)) with total hip (TH), lumbar spine (LS) and total body (TB) BMD, and used Poisson regression to estimate associations of anemia (in 1992–93; Hgb <13 g/dL in men; <12 g/dL in women) with “low BMD” defined as T-score less than −1 at the TH. In 1,277 participants with Hgb measured on average 2.9 years apart and BMD, we used linear regression to estimate the associations of annualized change in Hgb with TH, LS and TB BMD. All models included age, sex, study-site, race, smoking, alcohol use, weight, height, steroid use, physical activity score, self-reported health, previous cardiovascular disease and prior anti-fracture medication use. Results: No significant association was observed between Hgb, measured a mean 2.2 years prior to BMD, and BMD at the TH and LS in men (TH beta = −0.60 [x 10−2g/cm2per 1.1 g/dL Hgb], 95% CI: −1.88 to 0.68; LS beta = −1.69, 95% CI: −3.83 to 0.45) or women (TH beta = −0.49 [x 10−2g/cm2per 1.3 g/dL Hgb], 95% CI: −1.57 to 0.59; LS beta = −0.40, 95% CI: −2.57 to 1.76). Anemia was not observed to be significantly associated with low BMD in men (RR = 0.99, 95% CI: 0.72– 1.40) nor women (RR = 0.98, 95% CI: 0.82– 1.17). The mean change in Hgb was a loss of 0.06 g/dL/year (SD = 0.32). Change in Hgb was not observed to be significantly associated with BMD in men (TH beta = −0.55[x 10−2g/cm2per 1g/dL annualized Hgb change], 95% CI: −4.28 to 3.19; LS beta = 0.63, 95% CI: −5.38 to 6.65) or women (TH beta = 0.92, 95% CI: −1.96 to 3.79; LS beta = −1.77, 95% CI: −7.52 to 3.98). No significant association was observed between anemia and low bone density by T-score in men and women. Conclusions: These findings support neither the hypothesis that low Hgb prior to bone density or decreases in Hgb are associated with bone density in older community-dwelling adults nor the use of Hgb level as a case-finding tool to prompt BMD measurement.

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Section: Discussionsupporting

confidence: 93%

Section: Introductioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study

Valderrábano

Bůžková

Chang

et al. 2019

Bone

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“…The incidence of osteoporosis in allogeneic HSC transplantation recipients is about 50% (McClune & Majhail, ), and HSC transplantation increases the incidence of bone fractures (Pundole, Barbo, Lin, Champlin, & Lu, ). Recent clinical evidence also suggests that anemia due to aging is correlated with bone loss and fragility (Valderrabano et al, ; Valderrabano & Wu, ). All of this suggests a close connection between hematopoietic function and bone homeostasis, but direct links bridging the two in cellular function have yet to be found.…”

Section: Introductionmentioning

confidence: 99%

Deterioration of hematopoietic autophagy is linked to osteoporosis

et al. 2020

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Hematopoietic disorders are known to increase the risk of complications such as osteoporosis. However, a direct link between hematopoietic cellular disorders and osteoporosis has been elusive. Here, we demonstrate that the deterioration of hematopoietic autophagy is coupled with osteoporosis in humans. With a conditional mouse model in which autophagy in the hematopoietic system is disrupted by deletion of the Atg7 gene, we show that incapacitating hematopoietic autophagy causes bone loss and perturbs osteocyte homeostasis. Induction of osteoporosis, either by ovariectomy, which blocks estrogen secretion, or by injection of ferric ammonium citrate to induce iron overload, causes dysfunction in the hematopoietic stem and progenitor cells (HSPCs) similar to that found in autophagy-defective mice.Transcriptomic analysis of HSPCs suggests promotion of iron activity and inhibition of osteocyte differentiation and calcium metabolism by hematopoietic autophagy defect, while proteomic profiling of bone tissue proteins indicates disturbance of the extracellular matrix pathway that includes collagen family members. Finally, screening for expression of selected genes and an immunohistological assay identifies severe impairments in H vessels in the bone tissue, which results in disconnection of osteocytes from hematopoietic cells in the autophagy-defective mice. We therefore propose that hematopoietic autophagy is required for the integrity of H vessels that bridge blood and bone cells and that its deterioration leads to osteoporosis. SPSS 25.0. Experimental data were presented as means ± standard deviations (SDs), which was evaluated using Student's t tests.University, for their help in preparing human bone samples and creating mouse osteoporotic model, and Jin Qi from the Shanghai

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Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

Zhang

Sun²,

Zhang

et al. 2020

Advanced Science

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Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis, leading to the development of degenerative bone diseases, including osteoporosis, osteoarthritis, degenerative disk disease, and osteomalacia. Meanwhile, heavy metal-induced anemia has been found to be intertwined with degenerative bone diseases. However, the relationship and interplay among these adverse outcomes remain elusive. Thus, it is of importance to shed light on the modes of action (MOAs) and adverse outcome pathways (AOPs) responsible for degenerative bone diseases and anemia under exposure to heavy metals. In the current Review, the epidemiological and experimental findings are recapitulated to interrogate the contributions of heavy metals to degenerative bone disease development which may be attributable dependently and independently to anemia. A few likely mechanisms are postulated for anemia-independent degenerative bone diseases, including dysregulated osteogenesis and osteoblastogenesis, imbalanced bone formation and resorption, and disturbed homeostasis of essential trace elements. By contrast, remodeled bone microarchitecture, inhibited erythropoietin production, and disordered iron homeostasis are speculated to account for anemia-associated degenerative bone disorders upon heavy metal exposure. Together, this Review aims to elaborate available literature to fill in the knowledge gaps in understanding the detrimental effects of heavy metals on bone cells and bone homeostasis through different perspectives.

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Bone Density Loss Is Associated With Blood Cell Counts

Cited by 57 publications

References 41 publications

Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study

Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study

Deterioration of hematopoietic autophagy is linked to osteoporosis

Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

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